Ocular Hypertension Treatment Study 20-Year Follow-up: Coordinating Center Grant

高眼压治疗研究 20 年随访：协调中心拨款

• 批准号: 9755440
• 负责人: MAE O GORDON
• 金额: $ 118.95万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9755440
• 关键词: African American; Age; Archives; Biometry; Blindness; Certification; Clinical; Cohort Studies; Collaborations; Consent; Data; Data Set; Directories; Doctor of Philosophy; Ethics; Facebook; Frequencies; Grant; Guidelines; Health Insurance Portability and Accountability Act; Human Resources; Incidence; Institutional Review Boards; Internet; Joints; Letters; Monitor; Ocular Hypertension; Ophthalmology; Optic Disk; Participant; Patient Self-Report; Patient-Centered Care; Patients; Performance; Phase; Physiologic Intraocular Pressure; Population; Preventive treatment; Primary Open Angle Glaucoma; Procedures; Protocols documentation; Public Health; Publications; Reading; Reporting; Research; Resource Sharing; Risk; Risk Factors; Severities; Statistical Data Interpretation; Testing; Time; United States; Universities; Visual Fields; Washington; administrative database; cohort; cost; cost effective; evidence base; follow-up; hypertension treatment; improved outcome; medical schools; modifiable risk; payment; phase 1 study; phase 3 study; predictive modeling; programs; public health relevance; vision science

 DESCRIPTION (provided by applicant): Primary open-angle glaucoma (POAG) is one of the leading causes of blindness in the United States and many other nations and is the leading cause of blindness in African Americans. Elevated intraocular pressure (ocular hypertension or OHT) is a major risk factor for developing POAG and the only modifiable risk factor at present. 4-7% of the United States population above age 40 has OHT. A major public health issue is how to apply the principles of patient- centered care and manage this large group of people in an effective and cost-effective manner. The OHTS carefully followed OHT participants for a median of 13 years. (OHTS Phase 1 and 2) This includes 279 participants who developed POAG during the study, the largest inception cohort of POAG patients ever described. We propose to re-examine all surviving OHTS participants at 20 years or more in 2015-2017 (OHTS Phase 3). We will determine the incidence and severity of POAG in the OHTS cohort and determine the frequency and severity of self-reported functional limitations associated with POAG. We will also develop a 20-year prediction model for stratifying OHT patients by their risk of developing POAG and, among those who developed POAG, a prediction model for the rate of visual field loss. OHTS Phase 3 will allow us to develop evidence-based, 20-year guidelines for the management of patients with OHT. This will aid patients and clinicians to make informed decisions about the appropriate frequency of examinations and tests and the benefit of early, preventative treatment. Informed decisions should improve outcomes, reduce costs and reduce patient and clinician burden.

 描述(申请人提供)：原发性开角型青光眼(POAG)是美国和许多其他国家导致失明的主要原因之一，也是非裔美国人失明的主要原因。高眼压(高眼压或OHT)是POAG的主要危险因素，也是目前唯一可改变的危险因素。40岁以上的美国人口中有4%-7%患有OHT。一个重大的公共卫生问题是如何应用以患者为中心的护理原则，以有效和具有成本效益的方式管理这一大群体。OHTS仔细跟踪了OHT参与者13年的中位数。(OHTS第一阶段和第二阶段)这包括279名在研究期间患上POAG的参与者，这是迄今为止描述的最大的POAG患者初始队列。我们建议在2015-2017年(OHTS第三阶段)重新检查所有20岁或以上的OHTS参与者。我们将确定OHTS队列中POAG的发生率和严重程度，并确定与POAG相关的自我报告的功能障碍的频率和严重程度。我们还将开发一个20年的预测模型，根据OHT患者发生POAG的风险对他们进行分层，并在那些患有POAG的患者中，建立一个视野损失率的预测模型。OHTS第三阶段将允许我们为OHTS患者的管理制定以证据为基础的20年指南。这将有助于患者和临床医生就适当的检查和测试频率以及早期预防性治疗的好处做出明智的决定。知情的决定应该改善结果，降低成本，减轻患者和临床医生的负担。