The Role of Muscle Dynamics in Governing Achilles Subtendon Behavior Across the Lifespan

肌肉动力学在整个生命周期中控制跟腱下行为中的作用

• 批准号: 9758907
• 负责人: William H Clark
• 金额: $ 3.69万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9758907
• 关键词: Adhesions; Age; Aging; Anatomy; Animal Model; Animals; Architecture; Behavior; Biomechanics; Complex; Computer Simulation; Data; Development; Elderly; Electric Stimulation; Experimental Models; Gastrocnemius Muscle; Health; Human; Imaging Techniques; Impairment; Individual; Isometric Exercise; Isotonic Exercise; Knowledge; Link; Longevity; Lower Extremity; Measures; Mechanics; Modeling; Muscle; Musculoskeletal; Operative Surgical Procedures; Orthopedics; Output; Pattern; Public Health; Regenerative Medicine; Role; Series; Slide; Soleus Muscle; Speed; Techniques; Tendon structure; Tissue Engineering; Tissues; Triceps Brachii Muscle; Ultrasonic Transducer; Ultrasonography; Walking; achilles tendon; age effect; age related; aging population; design; evidence base; imaging probe; improved; in vivo; innovation; kinematics; muscle physiology; musculoskeletal imaging; negative affect; neuromuscular; novel; transmission process; walking speed; welfare; young adult

Project Summary In young adults, the positive mechanical power generated via triceps surae (i.e., gastrocnemius -GAS, soleus- SOL) muscle-tendon interaction is responsible for a large majority of the total power needed to walk. Recent evidence suggests that GAS and SOL transmit their forces through distinct, and perhaps mechanically independent, subtendons that merge and twist to form the Achilles tendon (AT). Consistent with our preliminary ultrasound imaging results in humans, animal models of the aging AT allude to adhesions between adjacent subtendons. We propose that these adhesions unfavorably couple the GAS and SOL, thereby negatively affecting fundamental mechanisms that influence muscle-subtendon interaction dynamics and triceps surae mechanical output during walking. Using a novel dual-probe imaging technique, our preliminary data reveal that triceps surae muscle dynamics may precipitate non-uniform displacement patterns in the architecturally complex AT of young adults, thereby facilitating mechanical independence of GAS (responsible for forward propulsion) and SOL (responsible for trunk support). Aim 1: Our proposal will leverage our novel dual-probe imaging technique to determine the role of muscle contractile dynamics in governing localized AT tissue displacements in young adults. Aim 2: We will then quantify the effects of aging on the role of muscle contractile dynamics in governing Achilles subtendon displacement (and vice versa). Aim 3: Finally, we will integrate our measured muscle- subtendon interaction dynamics into a computational model of the lower extremity to identify mechanistic causal relations between relevant architectural and neuromuscular factors in precipitating age-related changes during walking. The findings from this study will have immediate impact on our understanding of musculoskeletal mechanisms underlying age-related mobility impairment toward improving the health and welfare of our aging population. Moreover, our technological advancements in musculoskeletal imaging will revolutionize the use of in vivo ultrasound during functional locomotor behavior, with broad implications in humans and other animals. More broadly, the knowledge gained from this study could significantly accelerate the development of engineered tissues, regenerative medicine approaches and therapies, and orthopaedic surgical intervention.

项目摘要 在年轻人中，通过小腿三头肌产生的正机械功率（即，腓肠肌-GAS，比目鱼肌- SOL）肌肉-肌腱相互作用是行走所需总功率的主要原因。最近 有证据表明，GAS和SOL通过不同的，也许是机械的方式传递它们的力。 合并和扭转形成跟腱（AT）的独立子腱。与我们初步的 超声成像结果显示人类、衰老AT动物模型暗示相邻AT之间存在粘连 亚腱我们认为，这些粘连不利地耦合GAS和SOL，从而产生负面影响。 影响肌肉-肌腱下相互作用动力学和小腿三头肌力学的基本机制 行走时的输出。使用一种新的双探头成像技术，我们的初步数据显示， 腓肠肌的动力学可能会在结构复杂的AT中沉淀出不均匀的位移模式， 年轻的成年人，从而促进GAS的机械独立性（负责向前推进）， SOL（负责主干支持）。目标1：我们的提案将利用我们新颖的双探头成像技术 确定肌肉收缩动力学在控制年轻人局部AT组织移位中的作用， 成年人了目的2：然后，我们将量化衰老对肌肉收缩动力学在控制中的作用的影响。 跟腱下移位（反之亦然）。目标3：最后，我们将整合我们测量的肌肉- 肌腱下的相互作用动力学到一个计算模型的下肢，以确定机械因果 相关的结构和神经肌肉因素之间的关系，在沉淀年龄相关的变化， 走路这项研究的结果将对我们对肌肉骨骼的理解产生直接影响。 与年龄相关的运动障碍的潜在机制，以改善我们老年人的健康和福利 人口此外，我们在肌肉骨骼成像方面的技术进步将彻底改变 在功能运动行为过程中的体内超声，在人类和其他动物中具有广泛的意义。 更广泛地说，从这项研究中获得的知识可以显着加速工程技术的发展。 组织、再生医学方法和疗法以及整形外科干预。