Maintenance and Incidence of ME/CFS following Mono

摘要 目前尚不清楚哪些心理和生物变量是ME/CFS的潜在维持因素 因为很少有前瞻性研究在IM发作前收集基线数据， 在诊断为ME/CFS后前瞻性地随访这些受试者。在我们目前资助的NIH研究中， 重点是IM后ME/CFS发展的病前临床和生物学预测因素， 不同的大学生群体。健康和心理健康的一般筛查，以及血液， 在研究的所有三个阶段都获得了（第一阶段--学生健康时;第二阶段--他们当时 患有IM的急性病，第3阶段-IM后6个月，当他们发展为ME/CFS或康复时）。 第一波是指我们目前正在收集的数据，第二波将由拟议的赠款资助， 包括对最初的第1波受试者进行为期5年的随访。队列1包括那些 在第1波期间发展了IM，初步数据表明，这些学生在 IM后6个月未发生ME/CFS的患者的基线。队列2包括那些没有 在Wave 1中开发IM。我们预计，随着时间的推移，其中一些受试者将发展ME/CFS。我们的研究将 评估IM后ME/CFS的临床和生物维持因素，并确定 在年轻成人样本中前瞻性地观察ME/CFS的发病率。

Abstract It is unclear which psychological and biological variables are potential maintenance factors for ME/CFS following IM because few prospective studies have collected baseline data before the onset of IM and then followed these subjects prospectively following the diagnosis of ME/CFS. In our currently funded NIH study, the focus has been on pre-illness clinical and biological predictors of ME/CFS development following IM in a diverse group of college students. General screens of health and psychological well-being, as well as blood, were obtained at all three stages of the study (Stage 1 - when the students are well; Stage 2 – at the time they are acutely ill with IM, Stage 3 – six months after IM, when they have either developed ME/CFS or recovered). Wave 1 refers to data we are currently collecting and Wave 2 will be funded by the proposed grant and involves a five-year follow-up with the original Wave 1 subjects. Cohort 1 includes those college students who developed IM during Wave 1, and preliminary data indicate that these students showed marked differences at baseline from those who did not develop ME/CFS 6 months following IM. Cohort 2 includes those who did not develop IM in Wave 1. We expect some of these subjects will develop ME/CFS over time. Our study will assess both clinical and biological maintenance factors for of ME/CFS following IM, and determine prospectively the incidence of ME/CFS in a sample of young adults.