Maintenance and Incidence of ME/CFS following Mono

Mono 后 ME/CFS 的维护和发生率

• 批准号: 10191581
• 负责人: Leonard A Jason
• 金额: $ 28.29万
• 依托单位: DE PAUL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10191581
• 关键词: 2019-nCoV; Acute; Address; Adolescent; Behavioral; Biological; Biological Markers; COVID-19; COVID-19 diagnosis; COVID-19 pandemic; Characteristics; Chronic Disease; Chronic Fatigue Syndrome; Climacteric; Common Data Element; Contracts; Data; Data Set; Development; Employment Status; Epidemic; Evolution; Funding; Future; Giardiasis; Grant; Human Herpesvirus 4; Incidence; Individual; Infection; Infectious Mononucleosis; Intervention Trial; Interview; Leukocytes; Maintenance; Measures; National Institute of Neurological Disorders and Stroke; Nature; Nervous system structure; Participant; Patients; Perception; Plasma; Population; Predisposing Factor; Prevention trial; Principal Investigator; Process; Prospective Studies; Q Fever; Recovery; Research; Risk Factors; Ross river virus; SARS-CoV-2 infection; Sampling; Series; Serum; Students; Support System; Symptoms; Systemic infection; Time; United States National Institutes of Health; Virus Diseases; West Nile viral infection; Work; Youth; base; cohort; coping; epidemiology study; experience; follow-up; mental state; psychologic; sociodemographics; time use; university student; young adult

Abstract Behavioral and pathophysiological underpinnings of the development of COVID-19 are poorly understood. From 2014 through 2018, our research group collected psychological and biological data of 4,501 young adults. We are currently funded to re-contact and interview these subjects regarding symptoms of ME/CFS. This supplemental funding request would allow us to also collect data involving COVIDF-19 infection and recovery vs nonrecovery from that infection as well. Using our baseline data, we will be able to compare the biological and behavioral data of young adults prior to the epidemic and during the epidemic, we will be able to compare those who became ill with COVID-19 and those who did not, to identify possible predisposing characteristics and to determine those who fully recovered vs those who did not. We emphasize the urgent nature of the request, as we will need to see these patients starting in June, July, and August. This cohort is significant in our effort to identify risk factors predisposing patients to developing COVID-19, which may help uncover underlying mechanisms of COVID-19. We believe our proposal addresses an urgent need for research on “biological effects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and effects of COVID-19 on the nervous system”.

摘要 对COVID-19发展的行为学和病理生理学基础知之甚少。 从2014年到2018年，我们的研究小组收集了4，501名年轻人的心理和生物数据。 成年人了我们目前的资助，重新接触和采访这些主题的症状ME/CFS。 这项补充资金申请将使我们能够收集涉及COVIDF-19感染的数据， 从感染中恢复与不恢复。使用我们的基线数据，我们将能够比较 在流行病之前和流行病期间，我们将能够获得年轻人的生物和行为数据， 比较那些感染COVID-19的人和那些没有感染的人，以确定可能的诱因 特征，并确定那些谁完全恢复与那些谁没有。我们强调迫切 这是请求的性质，因为我们需要从6月、7月和8月开始看这些病人。本队列 这对我们努力确定易使患者患上COVID-19的风险因素具有重要意义，这可能有助于 揭示COVID-19的潜在机制。我们认为，我们的建议满足了以下迫切需要： 关于“严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）的生物学效应和 COVID-19对神经系统的影响”。