Maintenance and Incidence of ME/CFS following Mono

Mono 后 ME/CFS 的维护和发生率

• 批准号: 10554994
• 负责人: Leonard A Jason
• 金额: $ 20.07万
• 依托单位: DE PAUL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10554994
• 关键词: 19 year old; 2019-nCoV; Acute; Adolescent; Age; Amino Acids; Attention; Attenuated; Behavioral; Biological; Biological Markers; Cerebrospinal Fluid; Chicago; Chronic Fatigue Syndrome; Climacteric; Common Data Element; Comparative Study; Coping Skills; Data; Data Set; Development; Diagnosis; Employment Status; Evolution; Fatigue; Freezing; Helper-Inducer T-Lymphocyte; Human Herpesvirus 4; IL8 gene; Immune; Immune System Diseases; Immune response; Immunologic Markers; Immunologics; Immunology; Incidence; Infection; Infectious Mononucleosis; Inflammatory; Interview; Leukocytes; Lipids; Maintenance; Metabolic Marker; Metabolic Pathway; National Institute of Neurological Disorders and Stroke; Neuraxis; Neurotransmitters; Nitrogen; Nucleotides; Outcome; Participant; Pathway Analysis; Patient Self-Report; Patients; Pediatric Hospitals; Perception; Plasma; Post-Acute Sequelae of SARS-CoV-2 Infection; Principal Investigator; Production; Prospective Studies; Q Fever; Race; Reporting; Research; Risk Factors; Ross river virus; SARS-CoV-2 infection; SARS-CoV-2 positive; Sampling; Series; Serum; Students; Support System; Symptoms; Systemic infection; Testing; Time; United States National Institutes of Health; Virus Diseases; West Nile viral infection; Work; Youth; aged; base; biosignature; college; cytokine; epidemiology study; experience; flexibility; inflammatory marker; inflammatory milieu; mental state; metabolomics; novel; post SARS-CoV-2 infection; psychologic; recruit; response; sociodemographics; tool; university student

Abstract This proposal would allow us to compare EBV and SARS-CoV-2 immune markers and metabolomics on the samples from our unique data sets. Immune and metabolomic analyses are interesting discovery tools and an important aspect of the integrative approach we will use, with their broad and flexible potential for studying post-viral fatigue. We have also shown that college students with post-IM ME/CFS have an inflammatory profile, even at baseline, different from those who recover from IM (Jason, Cotler, et al., 2021). In addition, metabolomics has emerged as a novel tool for analyzing post-viral fatigue. Multiple studies have reported detectable changes in metabolic pathways related to energy production, amino acids, nucleotides, nitrogen, lipids, and neurotransmitters in patients with post-viral fatigue (Armstrong et al., 2014; Germain, Ruppert, Levine, & Hanson., 2017; Nagy-Szakal et al., 2018; Naviaux et al., 2016). Our study of immunology and metabolomics hopes to identify possible biosignatures for PASC and ME/CFS. Our primary aims are to determine immunologic and metabolomic risk factors for the development of PASC following SARS CoV-2 infection and ME/CFS following IM. We hypothesize that altered host immune and metabolomic profiles will be associated with post-viral fatigue following primary EBV and SARS-CoV-2 infection, in contrast to healthy controls. In addition, qualitative in-depth interviews will explore perceptions of the following: major life changes, fluctuations in employment status, changes in somatic symptoms, changes in coping strategies, changes in physical and mental status, and the evolution of support systems, to determine which if any of these factors are also important for the development and maintenance of PASC and ME/CFS.

抽象的 该提案将使我们能够比较 EBV 和 SARS-CoV-2 的免疫标记物和代谢组学 来自我们独特数据集的样本。免疫和代谢组学分析是有趣的发现工具和 我们将使用的综合方法的一个重要方面，具有广泛而灵活的研究潜力 病毒后疲劳。我们还表明，患有 IM ME/CFS 后的大学生有炎症 即使在基线时，其个人资料也与从 IM 中恢复的人不同（Jason、Cotler 等人，2021）。此外， 代谢组学已成为分析病毒后疲劳的新工具。多项研究报道 与能量产生、氨基酸、核苷酸、氮相关的代谢途径的可检测变化 病毒后疲劳患者的血脂和神经递质（Armstrong 等，2014；Germain，Ruppert， 莱文和汉森，2017；纳吉-萨卡尔等人，2018； Naviaux 等人，2016）。我们的免疫学研究和 代谢组学希望识别 PASC 和 ME/CFS 可能的生物特征。我们的主要目标是 确定 SARS CoV-2 后发生 PASC 的免疫学和代谢组危险因素 IM 后感染和 ME/CFS。我们假设宿主免疫和代谢组学特征的改变将 与健康人相比，与原发性 EBV 和 SARS-CoV-2 感染后的病毒后疲劳相关 控制。此外，定性深入访谈将探讨对以下方面的看法： 主要生活 变化、就业状况的波动、躯体症状的变化、应对策略的变化、 身体和精神状态的变化，以及支持系统的演变，以确定哪些（如果有的话） 这些因素对于 PASC 和 ME/CFS 的开发和维护也很重要。