Maintenance and Incidence of ME/CFS following Mono

Mono 后 ME/CFS 的维护和发生率

• 批准号: 10300446
• 负责人: Leonard A Jason
• 金额: $ 56.02万
• 依托单位: DE PAUL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10300446
• 关键词: Acute; Adolescent; Age; Applications Grants; Biological; Blood; Blood specimen; Chronic Fatigue Syndrome; Climacteric; Clinical; Common Data Element; Coping Skills; Data; Data Set; Development; Diagnosis; Disease; Employment Status; Enrollment; Evolution; Funding; Grant; Health; Human Herpesvirus 4; Incidence; Infectious Mononucleosis; Interview; Maintenance; National Institute of Neurological Disorders and Stroke; Natural History; Participant; Patients; Perception; Predisposing Factor; Prospective Studies; Research Proposals; Risk Factors; Sampling; Series; Students; Support System; Symptoms; Systemic infection; Time; United States National Institutes of Health; Well in self; Work; Youth; cohort; college; epidemiology study; experience; follow-up; longitudinal design; mental state; prospective; psychologic; university student; young adult

Abstract It is unclear which psychological and biological variables are potential maintenance factors for ME/CFS following IM because few prospective studies have collected baseline data before the onset of IM and then followed these subjects prospectively following the diagnosis of ME/CFS. In our currently funded NIH study, the focus has been on pre-illness clinical and biological predictors of ME/CFS development following IM in a diverse group of college students. General screens of health and psychological well-being, as well as blood, were obtained at all three stages of the study (Stage 1 - when the students are well; Stage 2 – at the time they are acutely ill with IM, Stage 3 – six months after IM, when they have either developed ME/CFS or recovered). Wave 1 refers to data we are currently collecting and Wave 2 will be funded by the proposed grant and involves a five-year follow-up with the original Wave 1 subjects. Cohort 1 includes those college students who developed IM during Wave 1, and preliminary data indicate that these students showed marked differences at baseline from those who did not develop ME/CFS 6 months following IM. Cohort 2 includes those who did not develop IM in Wave 1. We expect some of these subjects will develop ME/CFS over time. Our study will assess both clinical and biological maintenance factors for of ME/CFS following IM, and determine prospectively the incidence of ME/CFS in a sample of young adults.

摘要 目前尚不清楚哪些心理和生物变量是ME/CFS的潜在维持因素 因为很少有前瞻性研究在IM发作前收集基线数据， 在诊断为ME/CFS后前瞻性地随访这些受试者。在我们目前资助的NIH研究中， 重点是IM后ME/CFS发展的病前临床和生物学预测因素， 不同的大学生群体。健康和心理健康的一般筛查，以及血液， 在研究的所有三个阶段（第一阶段-当学生健康时;第二阶段-当他们 患有IM的急性病，第3阶段-IM后6个月，当他们发展为ME/CFS或康复时）。 第一波是指我们目前正在收集的数据，第二波将由拟议的赠款资助， 包括对最初的第1波受试者进行为期5年的随访。队列1包括那些 在第1波期间发展了IM，初步数据表明，这些学生在 IM后6个月未发生ME/CFS的患者的基线。队列2包括那些没有 在Wave 1中开发IM。我们预计，随着时间的推移，其中一些受试者将发展ME/CFS。我们的研究将 评估IM后ME/CFS的临床和生物维持因素，并确定 在年轻成人样本中前瞻性地观察ME/CFS的发病率。