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Functional reorganization of the language and domain-general multiple demand systems in aphasia

失语症中语言和领域通用多需求系统的功能重组

基本信息

批准号：
9888346
负责人：
Evelina Fedorenko
金额：
$ 62.42万
依托单位：
BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9888346
关键词：
Accounting Acute Adopted Adult Affect Age Alzheimer&apos s Disease Anatomy Aphasia Aphasia Tests Architecture Behavior Behavioral Bilateral Brain Brain region Chiroptera Chronic Clinical Cognition Cognitive Complex Data Data Set Development Functional Magnetic Resonance Imaging Health Individual Individual Differences Intervention Language Left Lesion Life Linguistics Link Location Malignant Neoplasms Measures Mediating Methodology Neuronal Plasticity Outcome Parietal Parietal Lobe Participant Patients Performance Persons Phenotype Play Process Property Recovery Recovery of Function Role Services Site Stimulus Stroke System Time Validation Work aging population aphasia recovery base behavior test cognitive performance comparison group effective intervention effective therapy frontal lobe hemisphere damage improved individualized medicine innovation language comprehension language impairment language processing novel patient subsets post stroke preference recruit relating to nervous system response stroke incidence stroke patient stroke survivor support network tool

项目摘要

PROJECT ABSTRACT Aphasia affects approximately one third of stroke survivors (Berthier, 2005), and between 30 and 43% of these remain severely affected in the long term (e.g. (Bakheit et al., 2007). With a rising burden of stroke, it is increasingly important to develop effective and individualized treatment for patients with aphasia. An understanding of the brain mechanisms that underlie plasticity and recovery is therefore essential. However, the problem to solve is far from trivial given that language impairment and recovery after stroke is impacted by many factors including premorbid differences in brain organization, size and site of lesion, and post-stroke behaviors. In the proposed work, we examine the brain regions that are capable of subserving language recovery. While the prevailing hypothesis is that language recovery is mediated by the regions of the fronto-temporal network – either the ipsilesional left-hemisphere (LH) regions or the homologous right-hemisphere (RH) regions, we examine a novel hypothesis that a domain-general fronto-parietal multiple demand (MD) network may also mediate language recovery in patients with aphasia (PWA). We propose to evaluate three possible changes in the functional architecture of the MD and language networks: (i) response magnitude in each network during language processing; (ii) intra-network synchronization among MD regions, and among language regions; and (iii) across-network synchronization between MD and language regions. We will first characterize post-stroke differences in each measure by comparing 40 chronic PWA and 40 age-matched controls. Then, we will identify individual differences in neural signatures that co-vary with differences in language performance on standard behavioral tests. Finally, we will assess the causal contribution of the MD network to language recovery in a subset of 40 PWA tested at two time points, both in fMRI and behavioral tasks. This work is innovative because it uses a suite of methodological tools to facilitate localize language processing in PWA by accounting for variability in lesion site, volume and anatomy-function mapping. Further, we examine a subset of patients at two time points, allowing a within group comparison of changes in the MD network over time and as a function of recovery. A key outcome of this project is the development of a comprehensive explanation for mechanisms of neuroplasticity and reorganization of language function in aphasia. Another outcome of the project is the delineation of neural phenotypes – including in the acute stage – that explain the variability in linguistic and cognitive performance of PWA while accounting for variability in anatomy-function mapping. A third important outcome will be to pave the way for new behavioral and neuro-stimulation therapies that capitalize on the engagement of the MD network in the service of language recovery. Establishing the potential recruitment of non-language regions (i.e., multiple demand regions) in the service of language recovery has profound implications for facilitating language recovery in aphasia.

项目摘要