Using MOST to optimize an HIV care continuum intervention for vulnerable populations
使用 MOST 优化针对弱势群体的 HIV 护理连续干预
基本信息
- 批准号:9888341
- 负责人:
- 金额:$ 76.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-07-01 至 2022-03-31
- 项目状态:已结题
- 来源:
- 关键词:AIDS preventionAIDS/HIV problemAddressAdherenceAdultAfrican AmericanAgeAlcohol or Other Drugs useAreaBehavioralBiological MarkersCaringClinicContinuity of Patient CareDiscipline of NursingEngineeringEnrollmentExperimental DesignsFrightFundingFutureHIVHairHealth Care CostsHybridsIndividualInterventionIntervention StudiesLatinoLiteratureMediator of activation proteinMedical RecordsMental HealthMentorshipMethodsMorbidity - disease rateNIH Office of AIDS ResearchParticipantPatientsPerformancePersonsPopulationPreparationPreventionPrimary Health CarePublic HealthRandomizedRandomized Controlled TrialsRecording of previous eventsResearchResearch MethodologyResearch PriorityResourcesRisk FactorsSamplingScienceScientistSelf DeterminationServicesSignal TransductionStructureSupport GroupsTestingTimeTreatment EfficacyTriad Acrylic ResinUnited States National Institutes of HealthViralViral Load resultVulnerable Populationsantiretroviral therapybehavior changecollegecommunity settingcost effectivecost effectivenessdesigneffective interventionethnic health disparityexperienceinnovationinterestintrinsic motivationmathematical modelmen who have sex with menmortalitymotivational enhancement therapymulti-component interventionmultiphase optimization strategypeerprimary outcomepublic health relevanceracial and ethnicracial and ethnic disparitiesrecruitsecondary outcomesexual minoritysocialsocial cognitive theorysocial stigmatheoriestherapy adherencetransmission processtreatment services
项目摘要
DESCRIPTION (provided by applicant): More than half of persons living with HIV/AIDS (PLHA) in the U.S. are insufficiently engaged in HIV primary care and not taking antiretroviral therapy (ART), mainly African Americans and Latinos. In the proposed project, two experienced and productive behavioral scientists will employ a potent and innovative research methodology, the Multiphase Optimization STrategy (MOST), to develop a highly efficacious, efficient, scalable, and cost-effective intervention to increase engagement along the HIV care continuum. Whereas randomized controlled trials (RCTs) are valuable for evaluating the efficacy of multi-component interventions as a package, they are not designed to evaluate which specific components contribute to efficacy. MOST, a pioneering, engineering-inspired framework, addresses this problem through highly efficient randomized experimentation to assess the performance of individual intervention components and their interactions. We propose to use MOST to engineer an intervention to increase engagement along the HIV care continuum for African American and Latino PLHA not well engaged in care and not taking ART. Further, the intervention will be optimized for cost-effectiveness. This efficiency and cost-effectiveness are critical in a time of constrained resources, and will also increase the intervention's future scalability. NIH has signaled its interest in MOST, and this is the first study to apply it in the ield of adult HIV treatment. A similar set of multi-level factors impede both HIV care and ART initiation for African American and Latino PLHA, primary among them individual (e.g., substance use, distrust, fear), social (e.g., stigma), and structural-level barriers (e.g., difficulties accesing ancillary services). Guided by a multi-level social cognitive theory, the study will evaluate 5 distinct intervention components (i.e., Motivational Interviewing sessions, pre-adherence preparation, support groups, peer mentorship, and patient navigation), each designed to address a specific barrier to HIV care and ART initiation. These components are well-grounded in the empirical literature and were found acceptable, feasible, and promising with respect to efficacy in a preliminary study. Study aims are: 1) using a highly efficient experimental design, identify which of 5 components contribute meaningfully to improvement in viral suppression, and secondary outcomes of ART adherence and engagement in HIV primary care; 2) identify mediators and moderators of component efficacy; and 3) using a mathematical modeling approach, build the most cost-effective and efficient intervention package from the efficacious components. A heterogeneous sample of African American and Latino PLHA (with respect to age, substance use, and sexual minority status) will be recruited with a proven hybrid sampling method using targeted sampling in community settings and peer recruitment (N=512). This highly innovative and significant study, which addresses a high- priority research area (NIH NOT-OD-15-137), will produce an HIV care continuum intervention for the nation's most vulnerable PLHA, optimized for cost-effectiveness, and with exceptional levels of efficacy, efficiency, and scalability.
项目成果
期刊论文数量(0)
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{{ truncateString('LINDA M COLLINS', 18)}}的其他基金
Optimization of behavioral and biobehavioral interventions: Building investigator capacity nationwide
行为和生物行为干预的优化:在全国范围内建设研究者能力
- 批准号:
10406304 - 财政年份:2020
- 资助金额:
$ 76.25万 - 项目类别:
Optimization of behavioral and biobehavioral interventions: Building investigator capacity nationwide
行为和生物行为干预的优化:在全国范围内建设研究者能力
- 批准号:
10626134 - 财政年份:2020
- 资助金额:
$ 76.25万 - 项目类别:
Optimization of behavioral and biobehavioral interventions: Building investigator capacity nationwide
行为和生物行为干预的优化:在全国范围内建设研究者能力
- 批准号:
10312276 - 财政年份:2020
- 资助金额:
$ 76.25万 - 项目类别:
Using MOST to optimize an HIV care continuum intervention for vulnerable populations
使用 MOST 优化针对弱势群体的 HIV 护理连续干预
- 批准号:
9925349 - 财政年份:2016
- 资助金额:
$ 76.25万 - 项目类别:
Using MOST to optimize an HIV care continuum intervention for vulnerable populations
使用 MOST 优化针对弱势群体的 HIV 护理连续干预
- 批准号:
9137118 - 财政年份:2016
- 资助金额:
$ 76.25万 - 项目类别:
Using MOST to optimize an HIV care continuum intervention for vulnerable populations
使用 MOST 优化针对弱势群体的 HIV 护理连续干预
- 批准号:
9301510 - 财政年份:2016
- 资助金额:
$ 76.25万 - 项目类别:
Center for Complex Data to Knowledge in Drug Abuse and HIV Behavioral Science
药物滥用和艾滋病毒行为科学复杂数据知识中心
- 批准号:
9134336 - 财政年份:2015
- 资助金额:
$ 76.25万 - 项目类别:














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