TRANSCRIPTIONAL REGULATION OF ANTIBODY RESPONSES AND IMMUNITY

翻译后摘要：抗体反应的持续时间变化很大，具体的疫苗或感染。具体 导致这些差异的免疫原和宿主反应的特征仍然很差 明白在本申请中，我们描述了BTB/POZ家族的两种转录因子，其发挥 对抗体产生持续时间的相反影响。这些因素中的第一个，Zbtb 20，促进血浆 细胞存活，并且是初级长期抗体应答所需的，当铝盐，但不是Toll样 受体配体用作佐剂。第二个因子，Zbtb 32，促进浆细胞死亡并限制 记忆B细胞回忆应答后抗体产生的持续时间，但不是一抗 应答基于这些发现，我们建议建立细胞事件，解释佐剂如何 影响免疫的持续时间，并揭示抗体多样性的生理后果 当回忆反应持续太久时，此外，我们建议确定分子 Zbtb 20和Zbtb 32如何控制体液免疫持续时间的机制。

Abstract: The duration of antibody responses varies widely with the specific vaccine or infection. The specific features of the immunogen and host responses that are responsible for these differences remain poorly understood. In this application, we describe two transcription factors of the BTB/POZ family which exert opposing effects on the duration of antibody production. The first of these factors, Zbtb20, promotes plasma cell survival and is required for primary long-term antibody responses when aluminum salts, but not Toll-like receptor ligands are used as the adjuvant. The second factor, Zbtb32, promotes plasma cell death and limits the duration of antibody production following memory B cell recall responses, but not primary antibody responses. Based on these findings, we propose to establish the cellular events that explain how adjuvants influence the duration of immunity, and to uncover the physiological consequences to the diversity of antibody responses when recall responses persist for too long. Moreover, we propose to identify the molecular mechanisms of how Zbtb20 and Zbtb32 function to control the duration of humoral immunity.