2019 Elastin, Elastic Fibers and Microfibrils Gordon Research Conference and Seminar

2019年弹性蛋白、弹性纤维和微纤维戈登研究会议暨研讨会

• 批准号: 9760801
• 负责人: DANIEL B RIFKIN
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9760801
• 关键词: Advocate; Affect; Aging; American; Aneurysm; Area; Atherosclerosis; Award; Basic Science; Biological; Biology; Biomedical Engineering; Biotechnology; Blood Vessels; Cardiovascular system; Chronic Obstructive Airway Disease; Clinical Research; Collaborations; Complex; Connective Tissue; Cutis Laxa; Data; Deposition; Development; Discipline; Disease; Dissection; Drug Industry; Dysplasia; Elastic Fiber; Elastic Tissue; Elasticity; Elastin; Elastin Fiber; Emerging Technologies; Eye; Fiber; Genetic; Genetic Diseases; Glaucoma; Growth Factor; Health; Hereditary Disease; Homeostasis; Hypertension; Inherited; International; Knowledge; Ligaments; Lipodystrophy; Loeys-Dietz Syndrome; Lung; Maine; Marfan Syndrome; Mentors; Microfibrils; Molecular; Muscle; Musculoskeletal; Musculoskeletal System; National Heart, Lung, and Blood Institute; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; New England; Participant; Pathogenesis; Patient Representative; Physiological; Postdoctoral Fellow; Property; Proteins; Pseudoxanthoma Elasticum; Pulmonary Hypertension; Regulation; Reporting; Research; Research Personnel; Role; Scientist; Signal Transduction; Skin; Skin Aging; Smooth Muscle Myocytes; Stiff skin syndrome; Students; Supravalvular aortic stenosis; Syndrome; System; Systemic Scleroderma; Systemic hypertension; Systems Analysis; Technology; Tendon structure; Time; Tissues; Travel; UV induced; Universities; Vascular remodeling; Weill-Marchesani syndrome; Williams Syndrome; arterial tortuosity; bone; calcification; career; collaborative environment; dissemination research; fibrillin; geleophysic dysplasia; human disease; improved; interdisciplinary approach; interest; mechanotransduction; research data dissemination; success; symposium; tissue regeneration; translational approach; translational medicine

PROJECT SUMMARY/ABSTRACT This application is for partial support of the 2019 Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on Elastin, Elastic Fibers & Microfibrils to be held from July 20th–21th (GRS) and July 21th– July 26th (GRC) 2019 at the University of New England in Biddeford, Maine. This biennial conference is the leading international forum for knowledge exchange and dissemination of research on elastic fibers and microfibrils, which are critical components of the musculoskeletal system, skin, vasculature, lung and other tissues. Research focusing on elastic fiber systems and its components is highly applicable to NIAMS, NHLBI, NIA, NEI, and NIGMS. Abnormal deposition and turnover of elastic fiber components and microfibrils is central to the pathogenesis of acquired diseases including atherosclerosis, aneurysms, chronic obstructive pulmonary disease, vascular remodelling in systemic and pulmonary hypertension, glaucoma, and skin aging mechanisms. Genetic disorders of direct relevance to this conference include Marfan syndrome, Weill- Marchesani syndrome, cutis laxa, stiff skin syndrome, systemic sclerosis, Williams-Beuren syndrome, supravalvular aortic stenosis, Urban-Rifkin-Davis syndrome, Loeys-Dietz syndrome and acromelic dysplasias. These combined acquired and genetic diseases affect millions of Americans and hundreds of millions worldwide. The specific aims of the 2010 GRS/GRC conference are: 1) To gather diverse investigators, representatives from patient advocate groups and other non-academic stakeholders from multiple disciplines for a focused, comprehensive conference to communicate and disseminate new data and concepts in elastic fiber related research. 2) To promote interactions and international collaborations, teams and networks between basic research groups, clinical research groups and companies which will inspire and facilitate multidisciplinary and translational approaches to investigating acquired and genetic elastic fiber diseases. 3) To improve health by stimulating knowledge transfer and by giving the opportunity to basic scientists and clinicians to exchange with representatives of biotech and pharmaceutical industries. 4) To familiarize investigators with advances in biological concepts and emerging technologies in different areas that may be applied to the field. 5) To provide a collegial and highly interactive atmosphere for discussion of new hypotheses and approaches, in which both junior and senior investigators may interact. 6) To increase the number and diversity of students, postdoctoral fellows and early career researchers attending the conference through the Gordon Research Seminar and mentor them toward career success in elastic fiber-related research with support through travel and excellence awards.

项目摘要/摘要 该申请是为2019年戈登研究会议（GRC）和戈登研究的部分支持 在7月20日至21日（GRS）和7月21日举行的弹性纤维和微纤维的弹性纤维和微纤维上的研讨会（GRS） 2019年7月26日（GRC）在缅因州比德福德的新英格兰大学举行。这个两年一次的会议是 领先的国际知识交流论坛和弹性纤维研究的传播 微纤维是肌肉骨骼系统，皮肤，脉管系统，肺和其他的关键组成部分 组织。针对弹性纤维系统及其组件的研究非常适用于NIAMS，NHLBI， Nia，Nei和Nigms。弹性纤维组件和微纤维的异常沉积和营业额为 获得性疾病发病机理的中心，包括动脉粥样硬化，动脉瘤，慢性阻塞性 肺疾病，全身和肺动脉高压的血管重塑，青光眼和皮肤老化 机制。与本次会议直接相关的遗传疾病包括Marfan综合征，Weill- Marchesani综合征，Cutis Laxa，硬皮肤综合征，系统性硬化症，Williams-Beuren综合征， 上主动脉狭窄，城市 - 里夫金 - 戴维斯综合症，洛伊斯 - 迪兹综合征和杂技 发育不良。这些合并后的获得和遗传疾病会影响数百万的美国人和数百个 全球数百万。 2010年GRS/GRC会议的具体目的是： 1）收集潜水员调查员，代表患者倡导者组和其他非学术 来自多个学科的利益相关者参加了一个集中，全面的会议，以进行交流和 在弹性纤维相关研究中传播新数据和概念。 2）促进基础研究之间的互动和国际合作，团队和网络 小组，临床研究小组和公司将激发和促进多学科和 调查获得和遗传弹性纤维疾病的转化方法。 3）通过刺激知识转移并为基础科学家和 临床医生与生物技术和制药行业的代表交流。 4）使研究人员熟悉不同的生物学概念和新兴技术的进步 可以应用于该领域的区域。 5）提供一种合作且高度互动的氛围，以讨论新的假设和方法， 初级和高级调查员都可以互动。 6）增加学生的数量和多样性，博士后研究员和早期职业研究人员 通过戈登研究研讨会参加会议，并指导他们在职业上取得成功 通过旅行和卓越奖励支持弹性纤维相关的研究。