2019 Elastin, Elastic Fibers and Microfibrils Gordon Research Conference and Seminar

项目摘要/摘要 本申请是对2019戈登研究会议(GRC)和戈登研究的部分支持 弹性蛋白、弹性纤维和微纤维研讨会(GRS)将于7月20日至21日(GRS)和7月21日- 2019年7月26日(GRC)，缅因州比德福德的新英格兰大学。这次两年一度的会议是 国际领先的弹性纤维和纤维研究知识交流和传播论坛 微原纤维是肌肉骨骼系统、皮肤、血管系统、肺和其他组织的重要组成部分 纸巾。专注于弹性纤维系统及其组件的研究高度适用于NIAMS，NHLBI， NIA、NEI和NIGMS。弹性纤维成分和微细纤维的异常沉积和周转 获得性疾病包括动脉粥样硬化、动脉瘤、慢性梗阻性疾病的发病机制 肺部疾病、全身和肺高压的血管重构、青光眼和皮肤老化 机械装置。与本次会议直接相关的遗传性疾病包括马凡综合征、Weill- Marchesani综合征，皮肤松弛，僵硬综合征，系统性硬化症，Williams-Beuren综合征， 主动脉瓣上狭窄、Urban-Rifkin-Davis综合征、Loeys-Dietz综合征和肢端综合征 发育不良。这些获得性和遗传性疾病共同影响着数百万美国人和数以百计的 全球数百万人。 2010年GRS/GRC会议的具体目标是： 1)聚集不同的调查人员、患者权益倡导团体的代表和其他非学术组织 来自多个领域的利益相关者召开集中、全面的会议，以进行沟通和 传播弹性纤维相关研究的新数据和新概念。 2)促进基础研究之间的互动和国际合作、团队和网络 团体、临床研究团体和公司，将激励和促进多学科和 研究获得性和遗传性弹性纤维疾病的翻译方法。 3)通过促进知识转让和向基础科学家和 临床医生与生物技术和制药行业的代表进行交流。 4)使调查人员熟悉不同领域的生物概念和新兴技术的进展 可应用于该领域的领域。 5)为讨论新的假设和方法提供一个合议和高度互动的氛围， 初级和高级调查人员都可以在其中进行互动。 6)增加学生、博士后研究员和早期职业研究人员的数量和多样性 通过戈登研究研讨会参加会议，并指导他们在 与弹性纤维相关的研究，通过旅行和优秀奖提供支持。

PROJECT SUMMARY/ABSTRACT This application is for partial support of the 2019 Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on Elastin, Elastic Fibers & Microfibrils to be held from July 20th–21th (GRS) and July 21th– July 26th (GRC) 2019 at the University of New England in Biddeford, Maine. This biennial conference is the leading international forum for knowledge exchange and dissemination of research on elastic fibers and microfibrils, which are critical components of the musculoskeletal system, skin, vasculature, lung and other tissues. Research focusing on elastic fiber systems and its components is highly applicable to NIAMS, NHLBI, NIA, NEI, and NIGMS. Abnormal deposition and turnover of elastic fiber components and microfibrils is central to the pathogenesis of acquired diseases including atherosclerosis, aneurysms, chronic obstructive pulmonary disease, vascular remodelling in systemic and pulmonary hypertension, glaucoma, and skin aging mechanisms. Genetic disorders of direct relevance to this conference include Marfan syndrome, Weill- Marchesani syndrome, cutis laxa, stiff skin syndrome, systemic sclerosis, Williams-Beuren syndrome, supravalvular aortic stenosis, Urban-Rifkin-Davis syndrome, Loeys-Dietz syndrome and acromelic dysplasias. These combined acquired and genetic diseases affect millions of Americans and hundreds of millions worldwide. The specific aims of the 2010 GRS/GRC conference are: 1) To gather diverse investigators, representatives from patient advocate groups and other non-academic stakeholders from multiple disciplines for a focused, comprehensive conference to communicate and disseminate new data and concepts in elastic fiber related research. 2) To promote interactions and international collaborations, teams and networks between basic research groups, clinical research groups and companies which will inspire and facilitate multidisciplinary and translational approaches to investigating acquired and genetic elastic fiber diseases. 3) To improve health by stimulating knowledge transfer and by giving the opportunity to basic scientists and clinicians to exchange with representatives of biotech and pharmaceutical industries. 4) To familiarize investigators with advances in biological concepts and emerging technologies in different areas that may be applied to the field. 5) To provide a collegial and highly interactive atmosphere for discussion of new hypotheses and approaches, in which both junior and senior investigators may interact. 6) To increase the number and diversity of students, postdoctoral fellows and early career researchers attending the conference through the Gordon Research Seminar and mentor them toward career success in elastic fiber-related research with support through travel and excellence awards.