Core A-Administrative Core

核心A--项目摘要 目前对胸主动脉瘤(TAA)的治疗通常包括降压药物或 手术干预。因此，交通安全援助呈现出未得到满足的医疗需求。在此应用程序中，更改了 机械转导作为治疗胸主动脉瘤的靶点，我们提出了一种新的 基于细胞感知的机械变化启动和促进TAAs的机制 他们的环境。这项计划拨款将集中于阐明我们的假设是否正确。核心A， 行政核心，将负责本计划项目所有方面的行政监督 格兰特(PPG)。因此，核心A将通过组织联合实验室来监测和促进整体科学进展 会议、年度务虚会、电子数据交换、执行委员会成员会议和 与科学咨询委员会(SAB)和内部咨询委员会(IAB)的互动。核心A将 监控各个组件的财务交易，确保NIH的指导方针得到遵守。 行政核心还将监督该计划与保险有关的所有其他监管要素 各个组件保持合规性，并将向NIH报告任何问题、更改或新的 首创精神。行政核心还将每年组织并向NIH提供一份进度报告 作为供资期结束时的最后进度报告，根据 组件PI。

Core A - Project Summary Current treatment for thoracic aortic aneurysms (TAA) usually consists of drugs to reduce blood pressure or surgical intervention. Thus, TAAs present an unmet medical need. In this application, Altered Mechanotransduction as a Therapeutic Target for Thoracic Aortic Aneurysm, we propose a novel mechanism for the initiation and promotion of TAAs based upon cell sensing of the mechanical changes in their environment. This programmatic grant will focus on elucidating whether our hypothesis is correct. Core A, the Administrative Core, will be in charge of administrative oversight of all aspects of this Program Project Grant (PPG). As such Core A will monitor and promote the overall scientific progress by organizing joint lab meetings, annual retreats, electronic exchange of data, Executive Committee member meetings, and interactions with both the Scientific Advisory Board (SAB) and the Internal Advisory Board (IAB). Core A will monitor the financial transactions of the individual components and insure that NIH guidelines are followed. The Administrative Core also will monitor all other regulatory elements of the program with respect to insuring that the individual components remain in compliance and will report to the NIH any problems, changes, or new initiatives. The Administrative Core will organize and provide to the NIH a Progress Report each year, as well as a final Progress Report at the end of the funding period, based upon the individual reports supplied by the component PIs.