2019 Modulation of Neural Circuits and Behavior Gordon Research Conference and Gordon Research Seminar

项目总结： 该提案请求R13支持戈登研究会议(GRC)的第三次会议 为青年科学家举办的联合戈登研究研讨会(GRS)，主题为“神经回路的调制和 2019年5月26日至31日，在瑞士Les Diablerets举办的《行为》活动。大脑调整信息处理和 优化行为，以应对不断变化的环境需求。这种惊人的灵活性依赖于 大脑功能在多个层面上的调节，从突触到神经回路。脑的调节 功能调节基本的生物状态，如进食、睡眠或性行为，对 认知大脑功能，如注意力和学习。对神经调节的深刻见解不仅是 对理解智力和行为的神经基础至关重要，也对理解不同的心理 状态、动机、注意力等重要现象受到控制。此外，机械的洞察力 神经调节机制是了解大脑功能障碍和疾病的关键，包括 抑郁症、创伤后应激障碍和许多其他疾病。这次会议将把科学家们聚集在一起 以不同的背景讨论当前的概念和这一广泛领域的令人兴奋的新成果。这次会议 将跨越多个学科，专注于具有很高协同潜力的主题。与其跟随，不如说 传统的细分领域广泛的神经调节，会议主题之间架起了科学 社区和纪律。我们期望，有组织的和非正式的讨论将产生新的 洞察和突出未来进展的有希望的方向。 这次会议是独一无二的，因为它将来自不同领域的科学家聚集在一起，以促进合作想法和 活动中合成神经调节的共同原理。这将由特定的 该计划中专门讨论一般性讨论的部分，将涵盖涉及 每一天的共同主题。由于基因组学和蛋白质组学的惊人进步，计算 分析复杂的数据集，新的成像和电生理学方法，以及操纵神经的能力 在先天和后天行为的活动中，神经科学家现在能够探测到已识别的 神经元、电路和完整的动物。关于神经调节的GRC/GRS将促进新的讨论 研究并加强板凳科学家、理论家和工具开发人员之间的沟通。最后，这一点 会议将有不同世代的与会者参加，有早期先驱调查人员的代表， 现任领导人和初级调查人员提供了密切交流的绝佳机会 知识和思想。综合起来，这些应该会在未来的研究中推动有希望的方向 神经调节，这符合NINDS及其姊妹机构NIDA、NICHD、NIA和 NIDCD。

PROJECT SUMMARY: This proposal requests R13 support for the third meeting of the Gordon Research Conference (GRC) with an associated Gordon Research Seminar (GRS) for young scientists on “Modulation of Neural Circuits and Behavior” from May 26-31, 2019, in Les Diablerets, Switzerland. Brains adjust information processing and optimize behaviors in response to ever-changing environmental demands. This astonishing flexibility relies on the modulation of brain functions at multiple levels, from synapses to neural circuits. The modulation of brain functions regulates basic biological states such as feeding, sleep or sex, and it is of key importance for cognitive brain functions such as attention and learning. Deep insights into neuromodulation are not only critical to understand the neural basis of intelligence and behavior but also to understand how different mental states, motivation, attention and other important phenomena are controlled. Moreover, mechanistic insights into neuromodulatory mechanisms are key to understand brain dysfunctions and diseases including depression, post-traumatic stress disorder, and many others. This conference will bring together scientists with diverse backgrounds to discuss current concepts and exciting new results in this broad field. The meeting will cut across disciplines and focus on topics that have a high potential to synergize. Rather than following traditional subdivisions of the broad field of neuromodulation, the session topics bridge between scientific communities and disciplines. We expect that the organized and informal discussions will generate new insights and highlight promising directions of future progress. This meeting is unique, since it brings together scientists from disparate fields to foster collaborative ideas and activities in the synthesis of the common principles of neuromodulation. This will be facilitated by specific sections of the program devoted to general discussions that will cover the presentations that address the common themes of each day. As a result of amazing advances in genomics and proteomics, computational analysis of complex datasets, new imaging and electrophysiology methods, and the ability to manipulate neural activity during innate and learned behavior, neuroscientists are now able to probe neuromodulation in identified neurons, circuits, and intact animals. The GRC/GRS on Neuromodulation will promote discussion of new research and strengthen communication between bench scientists, theorists, and tool developers. Finally, this meeting will feature participants of different generations, with representation of early pioneering investigators, current leaders, and junior investigators providing an exceptional opportunity for intimate exchanges of knowledge and ideas. Together these should drive promising future directions in the study of neuromodulation, which are in line with the mission of NINDS and its sister institutes, NIDA, NICHD, NIA and NIDCD.