2019 Modulation of Neural Circuits and Behavior Gordon Research Conference and Gordon Research Seminar

项目概要： 该提案请求 R13 支持戈登研究会议 (GRC) 第三次会议 为年轻科学家举办的相关戈登研究研讨会（GRS），主题为“神经回路的调节和 行为”，2019 年 5 月 26 日至 31 日，瑞士莱迪亚布勒雷。大脑调整信息处理和 优化行为以响应不断变化的环境需求。这种惊人的灵活性依赖于 从突触到神经回路的多个层面上大脑功能的调节。大脑的调节 功能调节基本的生物状态，如进食、睡眠或性行为，对于维持生命至关重要 认知大脑功能，例如注意力和学习。对神经调节的深入了解不仅 了解智力和行为的神经基础至关重要，但也了解不同心理的差异 状态、动机、注意力和其他重要现象受到控制。此外，机械见解 研究神经调节机制是了解大脑功能障碍和疾病的关键，包括 抑郁症、创伤后应激障碍等等。这次会议将汇集科学家 具有不同的背景，讨论这个广泛领域的当前概念和令人兴奋的新成果。会议 将跨越学科并重点关注具有高度协同潜力的主题。而不是跟随 会议主题是神经调节广泛领域的传统细分领域的科学之间的桥梁 社区和学科。我们期望有组织的非正式讨论将产生新的 见解并强调未来进展的有希望的方向。 这次会议是独一无二的，因为它汇集了来自不同领域的科学家，以促进合作思想和 合成神经调节活动的共同原理。这将通过具体措施来促进 节目中专门讨论一般性讨论的部分将涵盖针对以下问题的发言： 每天的共同主题。由于基因组学和蛋白质组学的惊人进步，计算 复杂数据集的分析、新的成像和电生理学方法以及操纵神经的能力 通过先天行为和习得行为期间的活动，神经科学家现在能够探索已识别的神经调节 神经元、电路和完整的动物。关于神经调节的 GRC/GRS 将促进新的讨论 研究并加强实验室科学家、理论家和工具开发人员之间的沟通。最后，这个 会议将有不同世代的参与者，其中包括早期开拓性研究人员的代表， 现任领导和初级研究人员提供了密切交流的绝佳机会 知识和想法。这些共同推动了未来研究的有前景的方向 神经调节，这符合 NINDS 及其姊妹机构 NIDA、NICHD、NIA 和 NIDCD。

PROJECT SUMMARY: This proposal requests R13 support for the third meeting of the Gordon Research Conference (GRC) with an associated Gordon Research Seminar (GRS) for young scientists on “Modulation of Neural Circuits and Behavior” from May 26-31, 2019, in Les Diablerets, Switzerland. Brains adjust information processing and optimize behaviors in response to ever-changing environmental demands. This astonishing flexibility relies on the modulation of brain functions at multiple levels, from synapses to neural circuits. The modulation of brain functions regulates basic biological states such as feeding, sleep or sex, and it is of key importance for cognitive brain functions such as attention and learning. Deep insights into neuromodulation are not only critical to understand the neural basis of intelligence and behavior but also to understand how different mental states, motivation, attention and other important phenomena are controlled. Moreover, mechanistic insights into neuromodulatory mechanisms are key to understand brain dysfunctions and diseases including depression, post-traumatic stress disorder, and many others. This conference will bring together scientists with diverse backgrounds to discuss current concepts and exciting new results in this broad field. The meeting will cut across disciplines and focus on topics that have a high potential to synergize. Rather than following traditional subdivisions of the broad field of neuromodulation, the session topics bridge between scientific communities and disciplines. We expect that the organized and informal discussions will generate new insights and highlight promising directions of future progress. This meeting is unique, since it brings together scientists from disparate fields to foster collaborative ideas and activities in the synthesis of the common principles of neuromodulation. This will be facilitated by specific sections of the program devoted to general discussions that will cover the presentations that address the common themes of each day. As a result of amazing advances in genomics and proteomics, computational analysis of complex datasets, new imaging and electrophysiology methods, and the ability to manipulate neural activity during innate and learned behavior, neuroscientists are now able to probe neuromodulation in identified neurons, circuits, and intact animals. The GRC/GRS on Neuromodulation will promote discussion of new research and strengthen communication between bench scientists, theorists, and tool developers. Finally, this meeting will feature participants of different generations, with representation of early pioneering investigators, current leaders, and junior investigators providing an exceptional opportunity for intimate exchanges of knowledge and ideas. Together these should drive promising future directions in the study of neuromodulation, which are in line with the mission of NINDS and its sister institutes, NIDA, NICHD, NIA and NIDCD.