Identifying, manipulating, and studying a complete sensory-to-motor model behavior circuit

识别、操作和研究完整的感觉到运动模型行为回路

基本信息

  • 批准号:
    10449063
  • 负责人:
  • 金额:
    $ 10万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-09-30 至 2023-07-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY We are requesting supplemental funds to obtain and apply transformative, recently validated methods to identify and study the neural correlates of behavior. How does the brain transform sensory information into complex behavior? The objective of the parent proposal is to identify the relevant neurons across the brain that are necessary to produce a relatively simple motivated behavior to study and identify fundamental principles underlying coding. Sensory-to- behavior circuits contain a variety of neural computations such as those that determine the identity and meaning of the sensed cues, gauge internal state, remember previous experience, and command muscle action. In the parent proposal we aim to identify and study an entire circuit from sensation across the brain to motor output. The original RFA called for the ability to leverage and study neural dynamics. At the time of the funding of the parent grant, we proposed to monitor brain-wide activity using cFos as a proxy, however this only provides a snapshot of an instant of brain activity in post-mortem animals. We complemented this approach with in vivo imaging of GCaMP activity by fiber photometry in awake behaving animals. This method reveals neural dynamics over seconds but is limited to image a small subset of the brain. Though these methods were state of the art at the time, they are both low through-put to implement and do not provide neural dynamics across the whole brain. Recently, functional ultrasound imaging (fUSi) has been validated to report dynamic images of the entire mouse brain (4 times/second) with a resolution of at least 100um. Dynamic, whole brain, high resolution imagine is truly transformative. fUSi is relatively easy and low-cost which will reduce resources including personnel, animals, and time. It will not just be faster and easier; we will learn more. We expect the additional information provided by fUSi to increase the confidence and scope of our conclusions. This will enable unprecedented activity profiles to inform all of our original aims including identifying key neural circuits and nodes, information flow within nodes and across the brain, and the change in activity with development and experience in and across individuals. Moreover, dynamic brain wide activity correlated with behavior will increase our ability to generate reliable models of information coding. Better models are expected to provide new, testable hypothesis that will benefit our understanding of information coding of sensory and social behavior and of brain function in general. An administrative supplement to implement this approach will result in more rapid achievement of our aims and better facilitate the goals of the initial RFA.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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LISA STOWERS其他文献

LISA STOWERS的其他文献

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{{ truncateString('LISA STOWERS', 18)}}的其他基金

2023 Modulation of Neural Circuits and Behavior Gordon Research Conference & Gordon Research Seminar
2023年神经回路与行为调节戈登研究会议
  • 批准号:
    10682921
  • 财政年份:
    2023
  • 资助金额:
    $ 10万
  • 项目类别:
2019 Modulation of Neural Circuits and Behavior Gordon Research Conference and Gordon Research Seminar
2019神经回路与行为调节戈登研究会议暨戈登研究研讨会
  • 批准号:
    9760082
  • 财政年份:
    2019
  • 资助金额:
    $ 10万
  • 项目类别:
Identifying, manipulating, and studying a complete sensory-to-motor model behavior circuit
识别、操作和研究完整的感觉到运动模型行为回路
  • 批准号:
    9789709
  • 财政年份:
    2018
  • 资助金额:
    $ 10万
  • 项目类别:
Identifying, manipulating, and studying a complete sensory-to-motor model behavior circuit
识别、操作和研究完整的感觉到运动模型行为回路
  • 批准号:
    9982441
  • 财政年份:
    2018
  • 资助金额:
    $ 10万
  • 项目类别:
Identifying, manipulating, and studying a complete sensory-to-motor model behavior circuit
识别、操作和研究完整的感觉到运动模型行为回路
  • 批准号:
    10224770
  • 财政年份:
    2018
  • 资助金额:
    $ 10万
  • 项目类别:
Identifying, manipulating, and studying a complete sensory-to-motor model behavior circuit
识别、操作和研究完整的感觉到运动模型行为回路
  • 批准号:
    10457850
  • 财政年份:
    2018
  • 资助金额:
    $ 10万
  • 项目类别:
Stress modulation of olfactory sensation
嗅觉的压力调节
  • 批准号:
    10055972
  • 财政年份:
    2016
  • 资助金额:
    $ 10万
  • 项目类别:
Identification of the ligands and sensory neurons that mediate pheromone behavior
介导信息素行为的配体和感觉神经元的鉴定
  • 批准号:
    8015230
  • 财政年份:
    2009
  • 资助金额:
    $ 10万
  • 项目类别:
Identification of the ligands and sensory neurons that mediate pheromone behavior
介导信息素行为的配体和感觉神经元的鉴定
  • 批准号:
    7763175
  • 财政年份:
    2009
  • 资助金额:
    $ 10万
  • 项目类别:
Identification of the ligands and sensory neurons that mediate pheromone behavior
介导信息素行为的配体和感觉神经元的鉴定
  • 批准号:
    8213699
  • 财政年份:
    2009
  • 资助金额:
    $ 10万
  • 项目类别:

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