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Identifying, manipulating, and studying a complete sensory-to-motor model behavior circuit

识别、操作和研究完整的感觉到运动模型行为回路

基本信息

批准号：
10457850
负责人：
LISA STOWERS
金额：
$ 66.56万
依托单位：
SCRIPPS RESEARCH INSTITUTE, THE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-30 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10457850
关键词：
Adolescent Adult Age Amygdaloid structure Anatomy Behavior Behavioral Brain Brain region Bypass Cell Nucleus Code Complex Cues Data Deposition Elements Elephants Esthesia Female Fiber Food Fright Goals Hypothalamic structure Image Ingestion Investigation Knowledge Learning Limbic System Logic Mediating Memory Modeling Motor Motor output Mus Muscle Nature Neurons Nose Olfactory Pathways Output Pattern Photometry Population Public Health Reproducibility Research Rest Scientist Sensory Skeleton Smell Perception Snakes Social Behavior Sphincter Spiders Stress Structure Testing Texture Touch sensation Urethral sphincter Urine Viral Work awake base blind experience insight knowledge of results male men motivated behavior neural circuit neuromechanism olfactory stimulus optogenetics programs relating to nervous system response sensory input sensory stimulus sensory system stem theories tool

项目摘要

Project Summary How does the brain transform sensory information into complex behavior? The objective of this proposal is to identify the relevant neurons across the brain that are necessary to produce a relatively simple motivated behavior to study and identify fundamental principles underlying coding. Sensory-to-behavior circuits must contain a variety of neural computations such as those that determine the identity and meaning of the sensed cues, gauge internal state, remember previous experience, and command muscle action. However, without knowing all of the parts of a model circuit, studying where and how these computations occur has proven difficult. Currently, complete circuit structure underlying most behaviors is largely unknown, and no complete model circuit has been traversed through the mouse limbic system. Therefore, study of neural coding relies on investigation of single brain regions, such as subdivisions of the amygdala or hypothalamus. Such focus may be akin to blind men touching different parts of an elephant; without perceiving the entirety, interpretation may become distorted. Here we propose that sensation-to-motivated-behavior employs an entire circuit and its study as a whole will accelerate understanding. We will overcome this bottleneck by leveraging the systematic control of the mouse’s olfactory system to elicit urine-marking behavior as an ideal model circuit. Upon smelling females, male mice are motivated to intentionally deposit copious urine marks to advertise their sexual availability. To investigate how this motivated circuit encodes behavior, we will 1) identify a complete, sensory-to-muscle, anatomic circuit that generates behavior, 2) determine the activity patterns of the relevant neurons in relationship to the behavior and to each other, and 3) determine the neural logic across the circuit that integrates internal state and experience. Completion of these aims will provide a unified picture of how a simple motivated behavior is coded in the brain. We expect that it will also provide the experimental means to identify and assign order and structure of basic known and unexpected principles that underlie how information is represented, altered, and integrated as it journeys from initial olfactory sensation to ultimate muscle activity. Once completed, both the approach and resulting knowledge will provide solutions for us and others to use as a template for the mechanistic study of the logic of sensory-to-behavior across other more complex motivated circuits. We anticipate that full knowledge of the parts and activity patterns the complete circuit will provide a crucial first step to understanding of how sensory systems, the brain, and the body collectively generate behavior.

项目总结