Identifying, manipulating, and studying a complete sensory-to-motor model behavior circuit
识别、操作和研究完整的感觉到运动模型行为回路
基本信息
- 批准号:10457850
- 负责人:
- 金额:$ 66.56万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-30 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:AdolescentAdultAgeAmygdaloid structureAnatomyBehaviorBehavioralBrainBrain regionBypassCell NucleusCodeComplexCuesDataDepositionElementsElephantsEsthesiaFemaleFiberFoodFrightGoalsHypothalamic structureImageIngestionInvestigationKnowledgeLearningLimbic SystemLogicMediatingMemoryModelingMotorMotor outputMusMuscleNatureNeuronsNoseOlfactory PathwaysOutputPatternPhotometryPopulationPublic HealthReproducibilityResearchRestScientistSensorySkeletonSmell PerceptionSnakesSocial BehaviorSphincterSpidersStressStructureTestingTextureTouch sensationUrethral sphincterUrineViralWorkawakebaseblindexperienceinsightknowledge of resultsmalemenmotivated behaviorneural circuitneuromechanismolfactory stimulusoptogeneticsprogramsrelating to nervous systemresponsesensory inputsensory stimulussensory systemstemtheoriestool
项目摘要
Project Summary
How does the brain transform sensory information into complex behavior? The objective of this
proposal is to identify the relevant neurons across the brain that are necessary to produce a
relatively simple motivated behavior to study and identify fundamental principles underlying
coding. Sensory-to-behavior circuits must contain a variety of neural computations such as
those that determine the identity and meaning of the sensed cues, gauge internal state,
remember previous experience, and command muscle action. However, without knowing all of
the parts of a model circuit, studying where and how these computations occur has proven
difficult. Currently, complete circuit structure underlying most behaviors is largely unknown, and
no complete model circuit has been traversed through the mouse limbic system. Therefore,
study of neural coding relies on investigation of single brain regions, such as subdivisions of the
amygdala or hypothalamus. Such focus may be akin to blind men touching different parts of an
elephant; without perceiving the entirety, interpretation may become distorted. Here we propose
that sensation-to-motivated-behavior employs an entire circuit and its study as a whole will
accelerate understanding. We will overcome this bottleneck by leveraging the systematic control
of the mouse’s olfactory system to elicit urine-marking behavior as an ideal model circuit. Upon
smelling females, male mice are motivated to intentionally deposit copious urine marks to
advertise their sexual availability. To investigate how this motivated circuit encodes behavior,
we will 1) identify a complete, sensory-to-muscle, anatomic circuit that generates behavior, 2)
determine the activity patterns of the relevant neurons in relationship to the behavior and to
each other, and 3) determine the neural logic across the circuit that integrates internal state and
experience. Completion of these aims will provide a unified picture of how a simple motivated
behavior is coded in the brain. We expect that it will also provide the experimental means to
identify and assign order and structure of basic known and unexpected principles that underlie
how information is represented, altered, and integrated as it journeys from initial olfactory
sensation to ultimate muscle activity. Once completed, both the approach and resulting
knowledge will provide solutions for us and others to use as a template for the mechanistic
study of the logic of sensory-to-behavior across other more complex motivated circuits. We
anticipate that full knowledge of the parts and activity patterns the complete circuit will provide a
crucial first step to understanding of how sensory systems, the brain, and the body collectively
generate behavior.
项目总结
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Social Behavior: How the Brain Thinks like a Mom.
社会行为:大脑如何像妈妈一样思考。
- DOI:10.1016/j.cub.2018.05.049
- 发表时间:2018
- 期刊:
- 影响因子:0
- 作者:Mukhopadhyay,Sourish;Stowers,Lisa
- 通讯作者:Stowers,Lisa
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LISA STOWERS其他文献
LISA STOWERS的其他文献
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{{ truncateString('LISA STOWERS', 18)}}的其他基金
2023 Modulation of Neural Circuits and Behavior Gordon Research Conference & Gordon Research Seminar
2023年神经回路与行为调节戈登研究会议
- 批准号:
10682921 - 财政年份:2023
- 资助金额:
$ 66.56万 - 项目类别:
2019 Modulation of Neural Circuits and Behavior Gordon Research Conference and Gordon Research Seminar
2019神经回路与行为调节戈登研究会议暨戈登研究研讨会
- 批准号:
9760082 - 财政年份:2019
- 资助金额:
$ 66.56万 - 项目类别:
Identifying, manipulating, and studying a complete sensory-to-motor model behavior circuit
识别、操作和研究完整的感觉到运动模型行为回路
- 批准号:
9789709 - 财政年份:2018
- 资助金额:
$ 66.56万 - 项目类别:
Identifying, manipulating, and studying a complete sensory-to-motor model behavior circuit
识别、操作和研究完整的感觉到运动模型行为回路
- 批准号:
9982441 - 财政年份:2018
- 资助金额:
$ 66.56万 - 项目类别:
Identifying, manipulating, and studying a complete sensory-to-motor model behavior circuit
识别、操作和研究完整的感觉到运动模型行为回路
- 批准号:
10224770 - 财政年份:2018
- 资助金额:
$ 66.56万 - 项目类别:
Identifying, manipulating, and studying a complete sensory-to-motor model behavior circuit
识别、操作和研究完整的感觉到运动模型行为回路
- 批准号:
10449063 - 财政年份:2018
- 资助金额:
$ 66.56万 - 项目类别:
Identification of the ligands and sensory neurons that mediate pheromone behavior
介导信息素行为的配体和感觉神经元的鉴定
- 批准号:
8015230 - 财政年份:2009
- 资助金额:
$ 66.56万 - 项目类别:
Identification of the ligands and sensory neurons that mediate pheromone behavior
介导信息素行为的配体和感觉神经元的鉴定
- 批准号:
7763175 - 财政年份:2009
- 资助金额:
$ 66.56万 - 项目类别:
Identification of the ligands and sensory neurons that mediate pheromone behavior
介导信息素行为的配体和感觉神经元的鉴定
- 批准号:
8213699 - 财政年份:2009
- 资助金额:
$ 66.56万 - 项目类别:
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