2019 Multi-Drug Efflux Systems GRC/GRS

项目摘要 发现和临床使用小分子治疗剂治疗感染性疾病的现代时代是 受到迅速蔓延的耐药性的威胁。耐药性影响所有主要的传染病群体， 但在诸如霍乱和霍乱等破坏性感染的病原体中尤其令人不安， 呼吸道疾病、疟疾和肺结核。基础、转化和药物之间的协同努力 迫切需要研究人员来防止耐药性的进一步传播， 预测和对抗目前和未来耐药病原体的方法。该提案要求 部分支持戈登研究会议（GRC）和戈登研究研讨会（GRS）， 多药外排系统将于2019年4月27日至5月3日在意大利的巴尔加举行。这次会议将填补一个重大空白， 解决关键问题和采取新的办法，以实现有效扭转 世界范围内的多药耐药性和开发具有最佳疗效和降低毒性的治疗方法。 本次会议和研讨会的目标是提供一个激励和协作的环境， 研究人员公开讨论未发表的工作，推动科学的边界，并促进科学 年轻的研究人员，该领域的领导者和在学术界工作的同事之间的互动 制药/生物技术行业。一个主要的目标是汇集研究人员的专业知识，在不同的 传统上只有有限的互动来分享进展和讨论挑战的学科 在外地的机会。研究多药耐药泵的研究人员参与 微生物和那些研究哺乳动物外排泵的目的是介绍技术进步 和变革性的方法。该GRC的目标将由国际 得到认可的主旨发言人、八次科学会议，30多名特邀发言人和其他 讨论领导人，以及独特的格式和设置，促进参与者之间富有成效的互动， 所有的职业生涯阶段。每场会议的发言者将提出前沿的、未发表的数据和创新的想法 这些问题对于靶向多药外排泵逆转耐药性的成功至关重要。的 GRC科学和海报会议的互动性质以及来自不同领域的研究人员的参与 研究部门是研究生和博士后研究员扩大他们的科学研究的最佳论坛 广度，与该领域的领导者互动，建立未来的合作关系，并考虑各种 职业道路。学员和代表人数不足的少数族裔提交的摘要将作为口头报告的对象。 在每一场会议上发言。通过在主要会议之前参加GRS，学员将 有更多的机会进行口头和海报展示，并在一个 培育环境。2019年多药外排系统的GRC和GRS将进一步刺激尖端 多药耐药性这一重要生物医学问题的基础和转化研究。

Project Summary The modern era of discovery and clinical use of small molecule therapeutics to treat infectious diseases is threatened by rapidly spreading drug resistance. Drug resistance affects all major groups of infectious diseases but is particularly troubling among causative agents of such devastating infections as diarrheal and respiratory diseases, malaria and tuberculosis. Concerted efforts among basic, translational and drug discovery researchers are urgently needed to prevent further spread of resistance and to develop effective approaches to anticipate and to counter present and future drug resistant pathogens. This proposal requests partial support for the Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on Multidrug Efflux Systems to be held in Barga, Italy, April 27-May 3, 2019. This conference will fill a major gap in addressing critical issues and novel approaches to achieve the goals of effective reversal of persistent multidrug resistance worldwide and the development of therapeutics with optimal efficacy and reduced toxicity. The goal of this conference and seminar is to provide a stimulating and collaborative environment for researchers to openly discuss unpublished work, push the boundaries of science, and foster scientific interactions between young investigators, leaders in the field, and colleagues working in academia and the pharmaceutical/biotechnology industry. A major goal is to bring together researchers with expertise in diverse disciplines who traditionally have limited interaction to share progress and engage in discussion of challenges and opportunities in the field. The participation of researchers studying multidrug resistance pumps in microorganisms and those studying mammalian efflux pumps is designed to introduce technological advances and transformative approaches to each field. The goals of this GRC will be accomplished by the internationally recognized keynote speakers, the eight scientific sessions with over 30 invited speakers and additional discussion leaders, and the unique format and setting that facilitates fruitful interactions between participants at all career stages. Speakers in each session will present cutting-edge, unpublished data and innovative ideas on issues that are critical to the success of targeting multidrug efflux pumps for the reversal of resistance. The interactive nature of the GRC scientific and poster sessions and the participation of researchers from diverse research sectors is an optimal forum for graduate students and postdoctoral fellows to expand their scientific breadth, interact with leaders in the field, establish future collaborative relationships and consider various career paths. Submitted abstracts from trainees and underrepresented minorities will be targeted for oral presentations in each session. Through participation in the GRS prior to the main conference, trainees will have additional opportunities for oral and poster presentations and to develop relationships with their peers in a nurturing environment. The 2019 GRC and GRS on Multidrug Efflux Systems will further stimulate cutting-edge basic and translational research on the important biomedical problem of multidrug resistance.