2019 Multi-Drug Efflux Systems GRC/GRS

2019 多药物外排系统 GRC/GRS

• 批准号: 9760371
• 负责人: Deanna L Kroetz
• 金额: $ 0.75万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-06 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9760371
• 关键词: Academia; Address; Affect; Basic Science; Biochemical; Biological Assay; Biology; Biophysics; Biotechnology; Career Choice; Chemicals; Climate; Clinical; Clinical Pharmacology; Collaborations; Communicable Diseases; Computer Analysis; Cryoelectron Microscopy; Data; Development; Discipline; Drug Efflux; Drug Kinetics; Drug Targeting; Drug resistance; Ensure; Environment; Fostering; Future; Genomics; Goals; Grant; Health; Hour; Human; Industry; Infection; Infectious Agent; International; Intervention; Italy; Knowledge; Learning; Lung diseases; Malaria; Malignant Neoplasms; Medicine; Mentorship; Methods; Microbiology; Minority; Modernization; Molecular; Multi-Drug Resistance; Nature; Oral; Participant; Pharmacodynamics; Pharmacologic Substance; Pharmacology; Pharmacotherapy; Postdoctoral Fellow; Property; Pump; Request for Proposals; Research; Research Personnel; Resistance; Science; Scientific Advances and Accomplishments; Scientist; Senior Scientist; Signaling Molecule; System; Time; Toxic effect; Translating; Translational Research; Tuberculosis; Underrepresented Minority; Woman; Writing; career; collaborative environment; design; diarrheal disease; drug discovery; drug resistant pathogen; efflux pump; global health; graduate student; improved; inhibitor/antagonist; innovation; membrane reconstitution; metabolomics; microorganism; new therapeutic target; novel; novel strategies; novel therapeutic intervention; organ on a chip; peer; posters; prevent; small molecule therapeutics; success; supportive environment; symposium; systems research; therapeutic development; tool; unpublished works

Project Summary The modern era of discovery and clinical use of small molecule therapeutics to treat infectious diseases is threatened by rapidly spreading drug resistance. Drug resistance affects all major groups of infectious diseases but is particularly troubling among causative agents of such devastating infections as diarrheal and respiratory diseases, malaria and tuberculosis. Concerted efforts among basic, translational and drug discovery researchers are urgently needed to prevent further spread of resistance and to develop effective approaches to anticipate and to counter present and future drug resistant pathogens. This proposal requests partial support for the Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on Multidrug Efflux Systems to be held in Barga, Italy, April 27-May 3, 2019. This conference will fill a major gap in addressing critical issues and novel approaches to achieve the goals of effective reversal of persistent multidrug resistance worldwide and the development of therapeutics with optimal efficacy and reduced toxicity. The goal of this conference and seminar is to provide a stimulating and collaborative environment for researchers to openly discuss unpublished work, push the boundaries of science, and foster scientific interactions between young investigators, leaders in the field, and colleagues working in academia and the pharmaceutical/biotechnology industry. A major goal is to bring together researchers with expertise in diverse disciplines who traditionally have limited interaction to share progress and engage in discussion of challenges and opportunities in the field. The participation of researchers studying multidrug resistance pumps in microorganisms and those studying mammalian efflux pumps is designed to introduce technological advances and transformative approaches to each field. The goals of this GRC will be accomplished by the internationally recognized keynote speakers, the eight scientific sessions with over 30 invited speakers and additional discussion leaders, and the unique format and setting that facilitates fruitful interactions between participants at all career stages. Speakers in each session will present cutting-edge, unpublished data and innovative ideas on issues that are critical to the success of targeting multidrug efflux pumps for the reversal of resistance. The interactive nature of the GRC scientific and poster sessions and the participation of researchers from diverse research sectors is an optimal forum for graduate students and postdoctoral fellows to expand their scientific breadth, interact with leaders in the field, establish future collaborative relationships and consider various career paths. Submitted abstracts from trainees and underrepresented minorities will be targeted for oral presentations in each session. Through participation in the GRS prior to the main conference, trainees will have additional opportunities for oral and poster presentations and to develop relationships with their peers in a nurturing environment. The 2019 GRC and GRS on Multidrug Efflux Systems will further stimulate cutting-edge basic and translational research on the important biomedical problem of multidrug resistance.

项目摘要 小分子治疗药物治疗传染病的现代时代和临床使用是 受到迅速扩散耐药性的威胁。耐药性影响所有主要的传染性群体 疾病，但尤其令人不安的是腹泻和 呼吸道疾病，疟疾和结核病。基本，翻译和毒品之间的一致努力 迫切需要发现研究人员，以防止进一步的抵抗力传播并发展有效 预测和抵抗和未来耐药病原体的方法。该建议要求 戈登研究会议（GRC）和戈登研究研讨会（GRS）的部分支持 2019年4月27日至5月3日至5月3日，将在意大利巴尔加举行的多饮用外系统。该会议将填补一个重大空白 解决关键问题和新颖的方法，以实现有效逆转持续的目标 全球多药耐药性以及具有最佳功效和降低毒性的治疗剂的发展。 这次会议和研讨会的目标是为 研究人员公开讨论未发表的工作，突破科学的界限并培养科学 年轻的研究人员，该领域的领导人与在学术界和工作的同事之间的互动 药物/生物技术行业。一个主要目标是将具有多样专业知识的研究人员聚集在一起 传统上互动有限的学科分享进度并讨论挑战 和现场的机会。研究多药抗性泵的研究人员的参与 微生物和研究哺乳动物外排泵的人旨在引入技术进步 以及每个领域的变革性方法。该GRC的目标将由国际实现 公认的主题演讲者，八个科学会议，有30多个受邀演讲者和其他 讨论负责人，以及促进参与者之间富有成果互动的独特格式和设置 所有职业阶段。每个会议中的演讲者都会呈现尖端，未发表的数据和创新想法 关于对靶向多饮用外泵的成功至关重要的问题，以逆转电阻。这 GRC科学和海报会议的互动性质以及来自多样的研究人员的参与 研究领域是研究生和博士后研究员的最佳论坛，以扩大其科学 广度，与该领域的领导人互动，建立未来的协作关系并考虑各种 职业道路。从学员和代表性不足的少数群体提交的摘要将成为针对口头的 每个会话中的演示文稿。通过在主要会议之前参加GRS，学员将 在口头和海报演示中有额外的机会，并与同龄人建立关系 培养环境。多饮用外系统上的2019 GRC和GRS将进一步刺激前沿 关于多药耐药性重要生物医学问题的基本和翻译研究。