Leveraging network control theory to explain individual differences to non-invasive brain stimulation

利用网络控制理论解释非侵入性脑刺激的个体差异

基本信息

  • 批准号:
    9606599
  • 负责人:
  • 金额:
    $ 14.54万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-05-18 至 2019-05-17
  • 项目状态:
    已结题

项目摘要

Project Summary / Abstract In an exciting era of growth in the use of non-invasive brain stimulation, new methods and applications are being disseminated widely with an increasing number of FDA approvals and equipment designed to probe or modulate the brain in fascinating new ways. The problem with this growing enthusiasm is that there are too few studies that have evaluated how tools such as transcranial magnetic stimulation (TMS) induce functional activation throughout a human brain, especially outside of the motor system. Neuromodulation made possible by administering trains of repetitive TMS (rTMS) is even more poorly understood since it requires capturing dynamic changes in the brain that are at the root of proposed changes in function. We have developed a protocol for assaying circuit communication by single pulse TMS delivered while recording functional MRI to follow brain wide effects of TMS to various prefrontal cortex targets. We are beginning to measure this circuit- specific communication flow before and after neuromodulatory rTMS to the same circuit to quantify changes in dynamics resulting from these acute brain interventions. With the proposed research, we plan to optimize targeting of two brain networks with TMS: inferior frontal gyrus to amygdala and lateral prefrontal to subgenual anterior cingulate cortex. By individualizing targeting from each person's functional MRI mapping, we believe that we can optimize our ability to affect the brain and ultimately better understand variability in behavioral response to TMS. A key set of proposed metrics for establishing a firmer understanding of TMS effects on the brain will be two different hypothesized dose/response relationships: 1) Circuit activation will increase as a function of absolute stimulation level and 2) Circuit communication will be modulated as a function of the cumulative number of rTMS pulses delivered during neuromodulatory brain stimulation. 3) Finally, to increase our chances of capturing a stratified sample of circuit integrity in the targeted pathways that are thought to be disrupted in affective disorders, a sub-sample of the recruited participants (who will otherwise be healthy) will be recently diagnosed with major depressive disorder. Significance: Our comprehensive assay of brain response to TMS will include TMS probe responses as well as resting fMRI recorded before, during, and after application of neuromodulatory TMS. This strategy will yield a significant step forward in understanding how non-invasive brain stimulation affects human brain functioning that can be a methodological and theoretical base for tool development and novel brain-based therapeutics.
项目摘要/摘要 在一个使用非侵入性脑刺激的令人兴奋的时代,新的方法和应用 随着越来越多的FDA批准和设计的设备来探测或 以令人着迷的新方式调节大脑。这种日益增长的热情的问题是,太少了 研究评估了经颅磁刺激(TMS)等工具如何诱导功能性 激活整个人脑,尤其是在运动系统之外。神经调节成为可能 通过管理一系列重复的TM(RTMS)更是鲜为人知,因为它需要捕获 大脑中的动态变化,是被提议的功能变化的根源。我们已经开发出一种 用于在记录功能MRI时传送的单脉冲TMS测试电路通信的协议 跟踪TMS对各种前额叶皮质靶点的全脑影响。我们开始测量这条线路- 神经调节rTMS前后到同一回路的特定通信流,以量化 这些急性大脑干预导致的动态变化。通过拟议的研究,我们计划优化 TMS靶向两个脑网络:额下回至杏仁核和外侧前额叶至膝下回 前扣带回皮质。通过从每个人的功能MRI映射中个性化目标,我们相信 我们可以优化我们影响大脑的能力,并最终更好地理解行为的可变性 对TMS的反应。一组建议的关键指标,用于更坚定地了解TMS对 大脑将有两种不同的假想剂量/反应关系: 1)电路激活将作为绝对刺激水平的函数而增加,2)电路通信将 作为神经调制期间递送的rTMS脉冲累积数量的函数进行调制 刺激。3)最后,为了增加我们在目标中捕获电路完整性分层样本的机会 被认为在情感障碍中受到干扰的通路,这是招募的参与者的一个子样本 (否则会很健康)最近会被诊断出患有严重的抑郁障碍。 意义:我们的大脑对TMS反应的综合分析也将包括TMS探针反应 分别于应用神经调节性TMS前、中、后记录静息fMRI。这一战略将会产生 在了解非侵入性脑刺激如何影响人类大脑功能方面向前迈出了重要的一步 这可以为工具开发和新的基于脑的疗法提供方法学和理论基础。

项目成果

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Desmond Oathes其他文献

Desmond Oathes的其他文献

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{{ truncateString('Desmond Oathes', 18)}}的其他基金

Non-invasive neuromodulation mechanisms and dose/response metrics
非侵入性神经调节机制和剂量/反应指标
  • 批准号:
    9357678
  • 财政年份:
    2016
  • 资助金额:
    $ 14.54万
  • 项目类别:
Developing Methods for Brain Stimulation Enhanced Fear Reversal in PTSD
开发脑刺激方法可增强 PTSD 患者的恐惧逆转
  • 批准号:
    8683995
  • 财政年份:
    2014
  • 资助金额:
    $ 14.54万
  • 项目类别:
Temporal dynamics of emotional processing in anxiety
焦虑情绪处理的时间动态
  • 批准号:
    7752664
  • 财政年份:
    2009
  • 资助金额:
    $ 14.54万
  • 项目类别:

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