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Dyadic yoga Program for Patients with Lung Cancer Undergoing Radiotherapy and their Family Caregivers

为接受放射治疗的肺癌患者及其家庭照顾者提供二元瑜伽课程

基本信息

批准号：
9761506
负责人：
Kathrin Milbury
金额：
$ 35.5万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-09 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9761506
关键词：
Address Adult Children Affect Behavior Therapy Behavioral Behavioral Sciences Biological Markers Blood Cancer Patient Caregivers Caring Data Disease Distress Dose Dyspnea Education Effectiveness Emotional Endocrine Evidence based intervention Family Family Caregiver Fatigue Future Goals Health education Hydrocortisone Immune Inflammatory Intervention Intervention Studies Investigation Knowledge Light Link Literature Lung diseases Malignant Neoplasms Malignant neoplasm of lung Measures Mediating Mediator of activation protein Meditation Mental Depression Modeling Nature Non-Small-Cell Lung Carcinoma Outcome Participant Patients Performance Periodicity Physical Function Physical Performance Population Prognostic Factor Qualitative Methods Quality of Care Quality of life Radiation therapy Randomized Randomized Controlled Trials Rehabilitation therapy Reporting Research Respiratory physiology SF-36 Saliva Sampling Scientific Advances and Accomplishments Siblings Sleep disturbances Source Spouses Subgroup Supportive care Symptoms Taxes Testing Treatment Efficacy United States Vulnerable Populations Walking Woman Work Yoga arm attentional control base body-mind cancer therapy cancer type caregiving clinical care clinically relevant clinically significant common symptom comparison group cytokine depressive symptoms design efficacy trial evidence base experience follow up assessment improved informal caregiving innovation intervention effect malignant breast neoplasm men patient population physical symptom primary outcome programs psychologic psychological distress psychological symptom secondary outcome skills survival prediction symptom management symptomatic improvement treatment duration treatment optimization treatment planning treatment response trial comparing usual care arm

项目摘要

PROJECT SUMMARY/ABSTRACT Patients with lung cancer, the most prevalent cancer in United States affecting both men and women, experience more debilitating physical and psychological symptoms than patients with other types of cancer. Common symptoms include reduced lung function, dyspnea, fatigue, sleep disturbances, and depression compromising their quality of life (QOL). In light of these symptoms, patients have a high need for care and support. Patients’ family caregivers are their most important and valued source of support and care; yet, caregiving is physically and emotionally taxing. In fact, family caregivers report high rates of psychological distress, fatigue, and sleep disturbances, which may compromise the quality of care they are able to provide to the patient. Given the interdependent nature of QOL in families, poor caregiver QOL may undermine patient QOL. Therefore, there is a need to established evidence-based dyadic supportive care programs targeting both patient and caregiver outcomes. Based on the promising findings of our pilot data, we proposed to examine a dyadic yoga program in patients with lung cancer (LC) and their family caregivers. To determine efficacy of a yoga program, the proposed research will randomly assign patient-caregiver dyads to either a dyadic yoga or a dyadic education group. Prior to randomization, both patients and caregivers will complete standard QOL measures. We will also collect biomarkers from blood and saliva samples. Patients will complete objective measures of physical performance. Based on their group assignment, dyads will either attend yoga sessions or health education sessions together. Both groups will receive the same intervention exposure (15 sessions, 60 min each) over the course of patients’ 6-week radiation treatment (RT) plans. During the treatment period, we will weekly assess patients’ symptoms. At the end of RT, 1, 2, 3, and 6-months later, dyads in both groups will be re-assessed. At the 3-month follow-up assessment, we will also collect qualitative samples to further understand participants’ experiences. The primary goal of this research is to demonstrate that, in the yoga group, patients will show better objective physical performance both patients and caregivers will report greater improvements in QOL compared to those in the dyadic education group. Secondary goals are to examine improvements in symptom burden, endocrine and immune dysregulation and symptom management and if these improvements mediate the physical function and QOL outcomes. Lastly, we examine factors that may moderate interventions effects, which will inform future studies expanding this program of research. This project represents a major step towards managing physical performance and QOL in lung cancer patients and their caregivers, a vulnerable yet understudied population.

项目总结/文摘