Michigan Integrative Musculoskeletal Health Core Center (Resource-based Center)

描述（由申请人提供）：密歇根综合肌肉骨骼健康核心中心 - 肌肉骨骼疾病仍然是一个巨大的医疗保健问题，占发达国家慢性病的 50% 以上。当前的金融形势不仅对研究者主导的科学项目构成挑战，而且由于个人预算缺乏与我们的科学邻居提供常规检测的灵活性，尤其威胁到合作研究。密歇根综合肌肉骨骼健康核心中心 (MiMHC) 将通过增加对 60 名中心研究人员的肌肉骨骼研究项目的基础的关键、专业资源和专业知识的获取，实现从分子机制到有机体功能的垂直整合、多尺度肌肉骨骼科学。 MiMHC 的结构与密歇根大学的新医疗保健计划保持一致，旨在促进跨学科以及基础科学家和临床医生之间的合作，通过更好地了解疾病和损伤机制来促进健康。 MiMHC 不仅增强了一群杰出的肌肉骨骼研究人员的能力，而且通过一项丰富计划充分利用他们的集体才能，该计划将促进跨组织相互作用和整个生命过程中性别特异性差异的新颖和新兴的肌肉骨骼研究。外展计划将通过新颖的每月研讨会系列和开发新颖的交流平台来创建一个丰富的肌肉骨骼科学家社区，该平台创建一个旨在加速讨论、批判性思维、研究可重复性和创新的虚拟校园。为了完成 为了实现这些目标，将建立一个管理核心来监督核心运营，三个资源核心将为研究界提供所有肌肉骨骼组织的组织学评估、结构和成分评估以及功能评估。资源核心采用分层结构，以促进从分子水平到器官水平的机制研究。访问资源核心将对中心研究人员产生影响，通过集中科学经济的核心技术，在财务上对中心研究人员产生影响；在科学上，通过提供核心主任的机会，核心主任是各自领域的专家，并将就技术的最佳选择、实验设计和数据解释提供指导。密歇根大学的环境非常适合发起和维持旨在增进对肌肉骨骼健康和疾病的了解的创新合作企业。

DESCRIPTION (provided by applicant): Michigan Integrative Musculoskeletal Health Core Center - Musculoskeletal disorders remain an enormous healthcare problem, accounting for more than fifty percent of chronic conditions in developed countries. The current financial landscape not only challenges investigator-led scientific programs but particularly threatens collaborative research given the lack of flexibility in individual budgets to offer routine assays with our scientific neighbors. The Michigan Integrative Musculoskeletal Health Core Center (MiMHC) will enable vertically integrative, multi-scale musculoskeletal science from molecular mechanisms to organismal function by increasing access to critical, specialized resources and expertise that are fundamental to the musculoskeletal research programs of 60 center investigators. The MiMHC is structured to be consistent with new healthcare initiatives at the University of Michigan aimed at promoting collaborations across disciplines and between basic scientists and clinicians to promote health by better understanding disease and injury mechanisms. The MiMHC not only enhances the capabilities of a group of outstanding musculoskeletal researchers but capitalizes on their collective talent through an Enrichment Program that will promote novel and emerging musculoskeletal research in cross-tissue interactions and sex- specific differences throughout the life course. An outreach program will create a rich community of musculoskeletal scientists through a novel monthly seminar series and the development of a novel communication platform that creates a virtual campus aimed at accelerating discussion, critical thinking, research reproducibility, and innovation. To accomplish these goals, an Administrative Core will be established to oversee core operations and three Resource Cores will provide Histological Assessments, Structural and Compositional Assessments, and Functional Assessments of all musculoskeletal tissues for the Research Community. The Resource Cores are hierarchically structured to facilitate mechanistic studies from the molecular-level through the organ-level. Access to the Resource Cores will be impactful to center investigators financially by centralizing core technologies for economy of science and scientifically by providing access to Core Directors who are experts in their field and who will provide guidance on the best choice of technologies, experimental design, and data interpretation. The UM environment is ideal for initiating and sustaining an innovative, collaborative venture aimed at advancing understanding of musculoskeletal health and disease.