Michigan Integrative Musculoskeletal Health Core Center (Overall Application)

密歇根综合肌肉骨骼健康核心中心（整体申请）

• 批准号: 10676777
• 负责人: KARL J JEPSEN
• 金额: $ 76.98万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10676777
• 关键词: Acceleration; Accounting; Adult; Artificial Intelligence; Basic Science; Biological Assay; Budgets; Cartilage; Center Core Grants; Chronic; Clinical; Clinical Research; Collaborations; Communication; Communities; Comprehensive Health Care; Critical Thinking; Data Analyses; Data Analytics; Dentistry; Developed Countries; Discipline; Disease; Education; Effectiveness; Engineering; Environment; Experimental Designs; Foundations; Funding; Funding Agency; Goals; Growth; Health; Health Promotion; Healthcare; Healthcare Systems; Histology; Home; Individual; Injury; Institution; Interdisciplinary Study; Leadership; Life Cycle Stages; Ligaments; Longevity; Machine Learning; Medicine; Mentorship; Michigan; Mission; Molecular; Muscle; Musculoskeletal; Musculoskeletal Diseases; National Institute of Arthritis, and Musculoskeletal, and Skin Diseases; Organ; Outcome; Prevalence; Prevention; Public Health; Reproducibility; Research; Research Personnel; Research Support; Resources; Risk; Scholarship; Science; Scientist; Series; Services; Sex Differences; Structure; System; Talents; Techniques; Technology; Tendon structure; Tissues; Training; Translational Research; United States; United States National Institutes of Health; Universities; age difference; age related; bone; clinically relevant; community building; disability; flexibility; hospital care; innovation; interest; medical attention; member; musculoskeletal injury; novel; operation; outreach program; programs; sex

Michigan Integrative Musculoskeletal Health Core Center - Overview Project Summary Musculoskeletal disorders remain an enormous public healthcare problem, accounting for more than fifty percent of chronic conditions in developed countries. The current financial landscape not only challenges investigator- led scientific programs, but particularly threatens collaborative research because lack of flexibility in individual budgets restricts resources and ability to share valuable techniques with our scientific neighbors. The Michigan Integrative Musculoskeletal Health Core Center (MiMHC) enables vertically integrated, multi-scale musculoskeletal science from molecular and omic-level mechanisms to organismal function and clinical outcomes by increasing access to critical, specialized resources and expertise that are fundamental to the musculoskeletal research programs of 90 Center investigators. The MiMHC is structured to be consistent with initiatives at the University of Michigan aimed at promoting collaborations across disciplines and between basic scientists and clinicians to promote health by better understanding disease and injury mechanisms. The MiMHC not only enhances the capabilities of a group of outstanding musculoskeletal researchers but also leverages their collective talent through an Enrichment Program that promotes novel and emerging musculoskeletal research in cross-tissue interactions and sex-specific differences throughout the life course. An outreach program creates a rich community of musculoskeletal scientists through a novel monthly seminar series that builds on existing momentum toward accelerating discussion, critical thinking, research rigor and reproducibility, and innovation. To accomplish these goals, an Administrative Core will oversee core operations and three Resource Cores to provide Structure, Composition, and Histology services, Functional assessment services, and Integrative Data Analytics services to all members of the MiMHC research community. The Resource Cores are structured to facilitate hierarchically mechanistic studies from the molecular and omic-levels through the organ-level and to the clinical setting. Access to the Resource Cores has been and will continue to be financially and scientifically impactful to Center investigators by centralizing core technologies and by providing access to Core Directors who are experts in their field and who will provide guidance on the best choice of technologies, experimental design, and data interpretation. The UM environment is ideal for continuing to build a strong research community and to sustain an innovative, collaborative venture aimed at advancing understanding of musculoskeletal health and disease and to conduct science highly relevant to the NIAMS mission.

密歇根综合肌肉骨骼健康核心中心-概述 项目摘要 肌肉骨骼疾病仍然是一个巨大的公共卫生问题，占50%以上， 在发达国家的慢性病。当前的金融格局不仅挑战调查人员- 领导的科学计划，但特别是威胁合作研究，因为缺乏灵活性，在个人 预算限制了与我们的科学邻居分享宝贵技术的资源和能力。密歇根 综合肌肉骨骼健康核心中心（MiMHC）实现垂直整合，多规模 肌肉骨骼科学从分子和组学水平的机制，以有机体功能和临床 通过增加获得关键的专门资源和专门知识的机会， 90名中心研究者的肌肉骨骼研究计划。MiMHC的结构符合 密歇根大学的倡议旨在促进跨学科和基础教育之间的合作， 科学家和临床医生通过更好地了解疾病和损伤机制来促进健康。MiMHC 不仅提高了一批优秀的肌肉骨骼研究人员的能力， 他们的集体才能，通过丰富的计划，促进新的和新兴的肌肉骨骼 研究整个生命过程中的跨组织相互作用和性别差异。一个外联 该计划通过一个新颖的每月研讨会系列创建了丰富的肌肉骨骼科学家社区， 建立在现有的势头，加快讨论，批判性思维，研究严谨性和可重复性， 创新添为了实现这些目标，一个行政核心将监督核心业务， 提供结构、组成和组织学服务的资源核心，功能评估服务， 和综合数据分析服务的MiMHC研究社区的所有成员。资源核心 的结构，以促进分层机制的研究，从分子和组学水平，通过 器官水平和临床环境。获取资源核心一直是，并将继续是财政 通过集中核心技术和提供访问， 核心董事是各自领域的专家，他们将就技术的最佳选择提供指导， 实验设计和数据解释。UM环境是继续构建强大的 研究社区，并维持一个创新的，合作的企业，旨在促进了解， 肌肉骨骼健康和疾病，并进行科学高度相关的NIAMS使命。

项目成果

Matrix/mineral ratio and domain size variation with bone tissue age: A photothermal infrared study

• DOI: 10.1016/j.jsb.2022.107878
• 发表时间: 2022-07-11
• 期刊: JOURNAL OF STRUCTURAL BIOLOGY
• 影响因子: 3
• 作者: Ahn, Taeyong;Jueckstock, Max;Holl, Mark M. Banaszak
• 通讯作者: Holl, Mark M. Banaszak

The Effect of Patellar Surface Morphology on Subchondral Bone Alignment When Matching Patellar Osteochondral Allografts to the Central Ridge of the Patella.

将髌骨同种异体骨移植物与髌骨中央脊匹配时，髌骨表面形态对软骨下骨排列的影响。

• DOI: 10.1177/03635465221087391
• 发表时间: 2022
• 期刊: The American journal of sports medicine
• 作者: Neral,Mithun;Patel,KaranA;Getty,Michael;Salka,Nabeel;Grant,JohnA
• 通讯作者: Grant,JohnA

Evaluation of Topology Optimization Using 3D Printing for Bioresorbable Fusion Cages: A Biomechanical Study in a Porcine Model.

使用 3D 打印对生物可吸收融合笼的拓扑优化进行评估：猪模型的生物力学研究。

• DOI: 10.1097/brs.0000000000004491
• 发表时间: 2023-02-15
• 期刊: Spine
• 影响因子: 3

Repairing Volumetric Muscle Loss in the Ovine Peroneus Tertius Following a 6-Month Recovery.

修复 6 个月恢复后绵羊腓骨第三肌的体积肌肉损失。

• DOI: 10.1089/ten.tea.2021.0187
• 发表时间: 2022
• 期刊: Tissue engineering. Part A
• 作者: Rodriguez,BrittanyL;Novakova,StoynaS;Vega-Soto,EmmanuelE;Nutter,GenevieveP;Macpherson,PeterCD;Larkin,LisaM
• 通讯作者: Larkin,LisaM

Masquelet's induced membrane technique: Review of current concepts and future directions.

• DOI: 10.1002/jor.24978
• 发表时间: 2021-04
• 期刊: Journal of orthopaedic research : official publication of the Orthopaedic Research Society
• 作者: Alford AI;Nicolaou D;Hake M;McBride-Gagyi S
• 通讯作者: McBride-Gagyi S