Yale Clinical and Translational Science Award

联系PD/PI：Sherwin，Robert S. 1.整体 耶鲁大学临床研究中心（YCCI）成立于2005年，旨在加强耶鲁大学的 临床和转化研究的基础设施，根据医学院的建议 战略规划委员会。不久之后，当NIH推出其新的临床和转化项目时， 科学奖，YCCI申请并成为耶鲁CTSA的家。从那时起，它的主要优先事项之一 一直支持下一代临床和翻译的教育和职业发展 investigators.如本申请中所描述的，该倡议已经取得了巨大成功，强调了 事实上，YCCI的K-Scholar项目的毕业生已经获得了47个NIH K奖，43个NIH RO 1奖项和65项基金会赠款，发表了> 1，800篇论文，并获得了> 2.4亿美元的独立资助。 科研经费值得注意的是，该计划的毕业生中有98%留在学术医学或追求 生物技术或制药行业的研究工作。YCCI也在其 推动加速将疾病相关发现转化为临床。如将要描述的，它提供了 耶鲁大学的研究人员在生物统计学和生物信息学、研究设计、方案等领域提供了关键帮助 开发、监管批准、患者招募、使用住院和门诊研究设施， 和预算支持，并使他们随时可以获得试点赠款和最先进的研究核心。的 其结果是，整个世界临床研究项目的数量和范围都大幅增加。 医学中心 在下一个资助周期，YCCI将在这些成就的基础上，重点关注基于团队的T1至T4 研究，包括整个生命周期的研究。YCCI还将寻求与耶鲁大学的新伙伴关系， 工程与应用科学开发一个创新的技术转让计划，称为中心， 生物和创新技术（CBIT），并与组织与管理学院提供一个 为临床医生和医生科学家提供领导力培训的新计划。此外，YCCI还将积极参与 耶鲁-纽黑文医院（YNHH）最近扩大了临床服务， 1，540张病床和每年超过100万的门诊人次，以及耶鲁医疗集团的增长 (YMG)，拥有超过100个临床专业的超过1，200名执业医生的网络。临床结果 卷（约400万例患者记录）使耶鲁大学的研究人员能够访问一个庞大的，多样化的患者基础， 结果研究和临床试验。总的来说，YCCI将利用耶鲁大学杰出的科学和临床 环境，并与其他CTSA中心合作，促进多学科团队科学的发展， 疾病预防、诊断和治疗的创新战略，并落实 卫生保健系统和整个人口的利益。 项目摘要/摘要第220页 联系PD/PI：Sherwin，Robert S. 项目叙述 耶鲁大学临床研究中心（YCCI）是基于团队的T1至T4研究的领导者，包括研究 在整个生命周期中。YCCI将利用耶鲁大学杰出的科学和临床环境， 与其他CTSA中心合作，促进多学科团队科学的发展， 制定疾病预防、诊断和治疗战略，并落实成果，造福于 卫生保健系统和整个人口。

Contact PD/PI: Sherwin, Robert S. 1. Overall Project Summary- The Yale Center for Clinical Investigation (YCCI) was created in 2005 to strengthen Yale's infrastructure for clinical and translational research, based on the recommendation of a Medical School strategic planning committee. Soon afterwards, when NIH launched its new program of Clinical & Translational Science Awards, YCCI applied and became the home of the Yale CTSA. Since then, one of its major priorities has been to support the education and career development of the next generation of clinical and translational investigators. As described in the present application, this initiative has met with great success, underscored by the fact that graduates of YCCI's K-Scholar program have received 47 individual NIH K Awards, 43 NIH RO1 awards, and 65 Foundation grants, published >1,800 papers, and obtained >$240 million in independent research funding. Remarkably, 98% of the program's graduates have stayed in academic medicine or pursued research careers in the biotech or pharmaceutical industries. YCCI has also made substantial progress in its push to accelerate the translation of disease-related discoveries into the clinic. As will be described, it provides Yale investigators with key assistance in areas including biostatistics and bioinformatics, study design, protocol development, regulatory approval, patient recruitment, access to inpatient and outpatient research facilities, and budgeting support, and gives them ready access to pilot grants and state-of-the-art research cores. The result has been a significant upsurge in the number and scope of clinical research projects throughout the Medical Center. In the next grant cycle, YCCI will build upon these achievements with an emphasis on team-based T1 to T4 research, including studies across the lifespan. YCCI will also pursue new partnerships with the Yale School of Engineering & Applied Science to develop an innovative technology transfer program called the Center for Biological and Innovative Technology (CBIT) and with the School of Organization & Management to offer a novel program of leadership training for clinicians and physician-scientists. In addition, YCCI will take active advantage of the recent expansion of clinical services by Yale-New Haven Hospital (YNHH), which now has 1,540 beds and more than 1 million outpatients visits per year, and the growth of the Yale Medical Group (YMG), which has a network of >1,200 practicing physicians in >100 clinical specialties. The resulting clinical volume (~4 million patient records) gives Yale researchers access to a large, diverse patient base for outcomes studies and clinical trials. Overall, YCCI will leverage Yale's outstanding scientific and clinical environment and work with other CTSA hubs to foster the growth of multidisciplinary team science, to develop innovative strategies for disease prevention, diagnostics, and therapeutics, and to implement results for the benefit of the health care system and the population as a whole. Project Summary/Abstract Page 220 Contact PD/PI: Sherwin, Robert S. Program Narrative Yale Center for Clinical Investigation (YCCI) is a leader in team-based T1 to T4 research, including studies across the lifespan. YCCI will leverage Yale University's outstanding scientific and clinical environment and work with other CTSA hubs to foster the growth of multidisciplinary team science, to develop innovative strategies for disease prevention, diagnostics, and therapeutics, and to implement results for the benefit of the health care system and the population as a whole.