Yale Clinical and Translational Science Award: Nwanaji-Enwerem Diversity in Health Related Research

耶鲁大学临床和转化科学奖：健康相关研究的 Nwanaji-Enwerem 多样性

• 批准号: 10733278
• 负责人: John H. Krystal
• 金额: $ 20.99万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10733278
• 关键词: AIDS prevention; Acceleration; Address; Adoption; Adverse effects; Award; Back; Bioinformatics; Bisexual; Black Populations; Black race; Categories; Cessation of life; Chronic; Chronic Disease; Circadian Rhythms; Clinical; Clinical Research; Clinical and Translational Science Awards; Communities; Development; Diagnosis; Discrimination; Disease; Doctor of Philosophy; Education; Emotional; Epidemic; Event; Evidence based treatment; Exposure to; Faculty; Funding; Gays; General Population; Global Awareness; Goals; Grant; HIV; HIV Infections; HIV diagnosis; Health; Health care facility; Healthcare; Immune System Diseases; Incidence; Individual; Infrastructure; Institution; Interdisciplinary Study; Intervention; Life; Link; Manuals; Mental Health; Mental disorders; Mentors; Mentorship; Minority Groups; Modification; National Center for Advancing Translational Sciences; Nurses; Outcome; Parents; Pattern; Personal Satisfaction; Persons; Phase; Population; Prevalence; Prevention strategy; Primary Care; Productivity; Psyche structure; Psychosocial Factor; Publications; Quality of life; Race; Research; Research Design; Research Infrastructure; Research Personnel; Resolution; Resources; Risk; Role; School Nursing; Scientist; Sexuality; Sleep; Sleep disturbances; Spirituality; Standardization; Testing; Therapeutic; Therapeutic Intervention; Training; Translational Research; Trauma; Underrepresented Populations; United States; United States National Institutes of Health; United States Substance Abuse and Mental Health Services Administration; Youth; antiretroviral therapy; behavioral health; black women; career; clinical care; clinical center; clinical investigation; comorbidity; cost effective; cost efficient; evidence base; experience; health care settings; implementation protocol; improved; improvement on sleep; innovation; marginalization; men; mortality; next generation; parent grant; physical conditioning; poor sleep; post-traumatic stress; post-traumatic symptoms; primary care clinic; programs; psychologic; psychological distress; psychological trauma; racial minority; racism; rapid eye movement; research study; service delivery; sexual minority group; sleep onset; social; social stigma; social stress; stress symptom; tenure track; therapeutically effective; tool; trauma centers; traumatic event; treatment adherence

SUMMARY: Uzoji Nwanaji-Enwerem The Parent Award: The Yale Center for Clinical Investigation (YCCI) was established in 2005 to develop institutional infrastructure that would better support translational and clinical research and to mentor the next generation of investigators. The YCCI was awarded the Clinical and Translational Science Award (CTSA) in 2006, now funded by the National Center for Advancing Translational Sciences (NCATS). Since then, the CTSA has be successfully renewed for Yale three times. The YCCI leverages this funding to provide essential resources and training to early investigators embarking on careers in translational and clinical research, including bioinformatic and computational research infrastructure, state-of-the-art research cores, pilot grants, study design support, administrative and regulatory support, and educational offerings. This funding has gone a long way, leading to successful mentorship of numerous junior investigators during the most critical phase of their careers. Since 2006, 161 past or current Junior Faculty Scholars have received more than $700 million in independent grants (~76% from NIH), producing ~6,300 publications, with 99% of Scholars remaining in clinical research. The Candidate: Ms. Uzoji Nwanaji-Enwerem is a PhD Candidate in the Yale School of Nursing, and her long- term career goal is to become an independent and productive nurse scientist, with a focus on conducting interdisciplinary research to understand the relationship between psychosocial factors, particularly stigma and discrimination, with sleep among persons from underrepresented backgrounds. The Project: Although only representing only 12% of the U.S. population, Black people account for as much 43% of people living with HIV disease. One major challenge is intersectional stigma (stigma related to race, sexuality, and HIV status), which often is a major contributor to experienced trauma in in these individuals. These traumatic experiences are associated with physical, mental, emotional, and behavioral health outcomes. The co- occurrence pattern of trauma and poor sleep among Black PLWH highlights an opportunity to improve health and quality of life through interventions that address both issues. Accelerated Resolution Therapy (ART) serves as a brief, cost-effective, and evidence-based treatment for combatting psychological trauma. Relationship to the Parent Grant: Ms. Nwanaji-Enwerem's research study directly advances the YCCI CTSA's T3 translational research aim for implementation of health care practices, particularly those that serve under- represented communities with respect to the management of back people living with HIV. During the award period, she will receive research mentorship from Dr. LaRon Nelson who has successfully mentored 10 trainees, 9 of which are now funded as independent faculty in tenure-track roles at their respective institutions. She will also receive research mentorship from Dr. Theddeus Iheanacho who is an expert in the study of innovative culturally-responsive strategies.

摘要：Uzoji Nwanaji-Enwerem 父母奖：耶鲁临床调查中心（YCCI）于2005年成立 可以更好地支持翻译和临床研究的机构基础设施 生成研究人员。 YCCI被授予临床和转化科学奖（CTSA） 2006年，现在由国家前进的转化科学中心（NCAT）资助。从那以后，CTSA 已经成功续签了耶鲁大学三次。 YCCI利用这笔资金提供必不可少的 对早期研究人员的资源和培训，从事转化和临床研究的职业，包括 生物信息学和计算研究基础设施，最先进的研究核心，试验赠款，研究 设计支持，行政和监管支持以及教育产品。这笔资金花了很长时间 方式，导致在最关键阶段的众多初级调查员成功指导 职业。自2006年以来，过去或当前的初级学者已获得超过7亿美元 独立赠款（NIH约76％），生产约6,300个出版物，临床中剩下99％的学者 研究。 候选人：Uzoji Nwanaji-Enwerem女士是耶鲁大学护理学院的博士学位候选人，她的长期 期限职业目标是成为一名独立和富有成效的护士科学家，重点是进行 跨学科的研究，以了解社会心理因素，尤其是污名和 歧视，来自代表性不足的人的睡眠。 该项目：尽管仅占美国人口的12％，但黑人占多大的影响 43％的患有艾滋病毒疾病的人。一个主要挑战是交叉污名（与种族有关的污名， 性行为和艾滋病毒状况），这通常是这些人的经历的创伤的主要贡献。这些 创伤经历与身体，心理，情感和行为健康成果有关。共同 黑色PLWH中创伤和睡眠不佳的发生模式突出了改善健康的机会 通过解决这两个问题的干预措施和生活质量。加速分辨率治疗（ART）服务 作为对抗心理创伤的短暂，成本效益和基于证据的治疗方法。 与父母赠款的关系：Nwanaji-Enwerem女士的研究直接推进了YCCI CTSA的研究 T3转化研究目的是实施医疗保健实践，尤其是那些服务不足的人 代表社区的艾滋病毒后背部患者的管理。在奖励期间 时期，她将获得成功指导10名学员的Laron Nelson博士的研究指导， 其中9个现在是在其各自机构中担任统治角色的独立教师的资金。她会的 还获得了创新研究专家Theddeus Iheanacho博士的研究指导 具有文化响应的策略。

项目成果

Ensuring Racial and Ethnic Inclusivity in Facial Vascularized Composite Allotransplantation.

• DOI: 10.1097/gox.0000000000005178
• 发表时间: 2023-08
• 期刊: Plastic and reconstructive surgery. Global open
• 作者: Kauke-Navarro M;Knoedler L;Knoedler S;Diatta F;Huelsboemer L;Stoegner VA;Mookerjee VG;Panayi AC;Butler PD;Pomahac B
• 通讯作者: Pomahac B

COVID-19 amplified racial disparities in the US criminal legal system.

• DOI: 10.1038/s41586-023-05980-2
• 发表时间: 2023-05
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Klein, Brennan;Ogbunugafor, C. Brandon;Schafer, Benjamin J.;Bhadricha, Zarana;Kori, Preeti;Sheldon, Jim;Kaza, Nitish;Sharma, Arush;Wang, Emily A.;Eliassi-Rad, Tina;Scarpino, Samuel V.;Hinton, Elizabeth
• 通讯作者: Hinton, Elizabeth

Association between early nonpharmacological management and follow-up for low back pain in the veterans health administration.

退伍军人健康管理中早期非药物治疗与腰痛随访之间的关联。

• DOI: 10.1016/j.xnsj.2023.100233
• 发表时间: 2023-06
• 期刊: North American Spine Society journal
• 作者: Coleman, Brian C;Lisi, Anthony J;Abel, Erica A;Runels, Tessa;Goulet, Joseph L
• 通讯作者: Goulet, Joseph L

Clinical characteristics and outcomes of patients with post-stroke epilepsy: protocol for an individual patient data meta-analysis from the International Post-stroke Epilepsy Research Repository (IPSERR).

• DOI: 10.1136/bmjopen-2023-078684
• 发表时间: 2023-11-15
• 期刊: BMJ open
• 影响因子: 2.9

Improving Pancreatic Cyst Management: Artificial Intelligence-Powered Prediction of Advanced Neoplasms through Endoscopic Ultrasound-Guided Confocal Endomicroscopy.

• DOI: 10.3390/biomimetics8060496
• 发表时间: 2023-10-19
• 期刊: Biomimetics (Basel, Switzerland)