Yale Clinical and Translational Science Award

联系PD/PI：Smith，Brian Richard 1.总体：项目摘要 耶鲁大学临床研究中心（YCCI）成立于2005年，旨在推进耶鲁大学的临床研究。 使命。一年后，YCCI成为耶鲁CTSA的所在地。在YCCI成立之初，耶鲁是一个国家 T0-T2转化研究的领导者，基础/转化科学培训，它支持独特的 奖学金计划，如罗伯特伍德约翰逊临床学者计划。从那时起，CTSA 在T1-T4研究中，耶鲁社区的不同组成部分之间产生了变革性的影响， 有效开展符合伦理的、创新的、严谨的和可复制的研究的中心基础设施， 以及培养下一代研究领导者。从规模、广度、质量和影响力的任何衡量标准来看， CTSA的研究事业和教育使命都为耶鲁取得了巨大的成功。 这一更新申请并不仅仅是为了保持卓越，而是为了使YCCI能够推动 耶鲁大学T1-T4转化研究使命及其博士前和博士后的持续转型 培训使命，并促进跨CTSA中心的合作。首先，它将支持信息学， 计算机技术的进步推动了学习健康系统的出现。在这样做时，它将借鉴 耶鲁纽黑文卫生系统，一个六家医院2,681张病床的联盟，提供超过240万 来自上韦斯特切斯特县、整个康涅狄格州和罗得岛州南部的患者的门诊访问 岛它还将帮助年轻科学家利用这一基础设施进行影响人类健康的研究。 医疗保健的未来。第二，它将支持那些支持发展中国家的技术和科学进步。 个性化医疗的出现，包括多组学和成像。YCCI将提供试点赠款支持 和培训，以促进研究事业和研究团队的发展，从而加深我们的见解 病理生理学，并建立个性化治疗。第三，它将涉及更广泛和更多的 不同的教师，学员和社区代表团体合作解决的使命 医疗保健差距对患者、其家庭和公共卫生构成重大负担。到 支持这一使命，YCCI还将促进以社区为基础的研究事业的发展， 多样化的年轻研究人员群体，并加强整体临床研究队伍。 项目摘要/摘要第177页 联系PD/PI：Smith，Brian Richard # ! ! % "# # " ! "#! !# ! & # # ! $ " ! " ! ! # ) # # % ! " $ # " # # #! # ! ! # ! # #! " # " % ! # ! ' " % ! " #(*" $#"# # $ # " # % ! # & # # "#! # & % # ("# # ! # ! # "("# # # ! " # $ # " & & ! & # # ! " # "# ! # $!# ! ! &# $ # " ! ( # " % % # % ! # % ! " # " "#! # " ! " " ! % # "# " # ! $# " # # # ! & ! ! "$ #" ! # # $ # " # ! # "("#

Contact PD/PI: Smith, Brian Richard 1. Overall: Project Summary The Yale Center for Clinical Investigation (YCCI) was created in 2005 to advance Yale's clinical research mission. One year later, YCCI became the home of the Yale CTSA. At YCCIs inception, Yale was a national leader in T0-T2 translational research, basic/translational science training, and it supported distinctive fellowship programs such as the Robert Wood Johnson Clinical Scholars Program. Since then, the CTSA has had a transformative impact linking diverse components of the Yale community in T1-T4 research, providing the central infrastructure for the effective conduct of ethical, innovative, rigorous, and reproducible research, and in training the next generation of research leaders. By any metric of scale, breadth, quality, and impact, both the CTSA's research enterprise and its educational mission have been enormously successful for Yale. This renewal application does not simply seek to maintain excellence, but to enable YCCI to drive the continued transformation of the Yale T1-T4 translational research mission and its predoctoral and postdoctoral training mission and to promote collaboration across CTSA hubs. First, it will support informatics and computational advances that drive the emergence of a learning health system. In so doing, it will draw on the Yale New Haven Health System, a six-hospital 2,681-bed consortium that provides more than 2.4 million outpatient visits from patients from upper Westchester county, throughout Connecticut, and southern Rhode Island. It will also prepare young scientists to draw on this infrastructure to conduct research that influences the future of healthcare. Second, it will support technological and scientific advances in areas that will support the emergence of personalized healthcare, including multi-omics and imaging. YCCI will provide pilot grant support and training to foster the development of research careers and research teams that can deepen our insights into pathophysiology and build toward personalized treatments. Third, it will engage a broader and more diverse group of faculty, trainees, and community representatives to collaborate in the mission of addressing healthcare disparities that constitute a major burden on patients, their families, and on public health. To support this mission, YCCI will also foster the development of careers in community-based research from a diverse group of young investigators and enhance the overall clinical research workforce. Project Summary/Abstract Page 177 Contact PD/PI: Smith, Brian Richard # ! ! % "# # " ! "#! !# ! & # # ! $ " ! " ! ! # ) # # % !" $ # " # # #! # ! ! # ! # #! " # " % ! # ! ' " % !" #(*" $#"# # $ # " # % ! # & # # "#! # & % # ("# # ! # ! # "("# # # ! " # $ # " & & ! & # # ! " # "# ! # $!# ! ! &# $ # " !( # " % % # % ! # % ! " # " "#! # " ! " " ! % # "# " # ! $# " # # # ! & ! ! "$ #" ! # # $ # " # ! # "("#