Yale Clinical and Translational Science Award

联系PD/PI：Smith，Brian Richard 1.总体情况：项目总结 耶鲁大学临床研究中心(YCCI)成立于2005年，旨在推动耶鲁大学的临床研究 任务。一年后，YCCI成为耶鲁CTSA的所在地。在YCCIS成立之初，耶鲁是一个全国性的 在T0-T2翻译研究、基础/翻译科学培训方面处于领先地位，并支持独特的 奖学金计划，如罗伯特·伍德·约翰逊临床学者计划。从那时起，CTSA已经 在T1-T4研究中产生了革命性的影响，将耶鲁社区的不同组成部分联系在一起，提供 有效进行符合道德的、创新的、严谨的和可重复的研究的中央基础设施， 以及在培训下一代研究领导者方面。从规模、广度、质量和影响的任何标准来看， 对于耶鲁来说，CTSA的研究事业和教育使命都取得了巨大的成功。 这一续签申请不仅仅是为了保持卓越，而是为了使YCCI能够推动 耶鲁大学T1-T4翻译研究任务及其博士后和博士后的持续转型 培训任务，并促进CTSA各中心之间的协作。首先，它将支持信息学和 推动学习型健康系统出现的计算进步。在这样做时，它将利用 耶鲁纽黑文健康系统，一个由六家医院组成的联盟，拥有2681张床位，提供超过240万张床位 来自上韦斯特切斯特县、整个康涅狄格州和南罗德州的患者的门诊就诊 小岛。它还将使年轻科学家做好准备，利用这一基础设施进行影响 医疗保健的未来。第二，它将支持技术和科学进步，支持 个性化医疗的出现，包括多组学和成像。YCCI将提供试点赠款支持 和培训，以促进研究职业和研究团队的发展，从而加深我们的洞察力 进入病理生理学，并朝着个性化治疗迈进。第三，它将参与更广泛和更多的 由不同的教职员工、受训人员和社区代表组成的团体，协作完成以下任务 医疗保健不平等对患者、他们的家人和公共卫生构成了重大负担。至 为了支持这一使命，YCCI还将促进社区研究事业的发展 多样化的年轻研究人员群体，增强整体临床研究队伍。 项目摘要/摘要页177 联系PD/PI：Smith，Brian Richard #！！%“##”！“#！#！&##！$” ！“！！#)##%！”$#“#！# #！“#”%！‘“%！”#(*“$#”##$# “#%！#&##”#！#&%#(“##！#！# “(”#！“#$#”&&！&##！“#！#$！#！&# $#“！(#”%%#%！#%！“#”“#！#”“ ！%#“#”#！$#“#！&！”$#“## $#“#！#”(“#

Contact PD/PI: Smith, Brian Richard 1. Overall: Project Summary The Yale Center for Clinical Investigation (YCCI) was created in 2005 to advance Yale's clinical research mission. One year later, YCCI became the home of the Yale CTSA. At YCCIs inception, Yale was a national leader in T0-T2 translational research, basic/translational science training, and it supported distinctive fellowship programs such as the Robert Wood Johnson Clinical Scholars Program. Since then, the CTSA has had a transformative impact linking diverse components of the Yale community in T1-T4 research, providing the central infrastructure for the effective conduct of ethical, innovative, rigorous, and reproducible research, and in training the next generation of research leaders. By any metric of scale, breadth, quality, and impact, both the CTSA's research enterprise and its educational mission have been enormously successful for Yale. This renewal application does not simply seek to maintain excellence, but to enable YCCI to drive the continued transformation of the Yale T1-T4 translational research mission and its predoctoral and postdoctoral training mission and to promote collaboration across CTSA hubs. First, it will support informatics and computational advances that drive the emergence of a learning health system. In so doing, it will draw on the Yale New Haven Health System, a six-hospital 2,681-bed consortium that provides more than 2.4 million outpatient visits from patients from upper Westchester county, throughout Connecticut, and southern Rhode Island. It will also prepare young scientists to draw on this infrastructure to conduct research that influences the future of healthcare. Second, it will support technological and scientific advances in areas that will support the emergence of personalized healthcare, including multi-omics and imaging. YCCI will provide pilot grant support and training to foster the development of research careers and research teams that can deepen our insights into pathophysiology and build toward personalized treatments. Third, it will engage a broader and more diverse group of faculty, trainees, and community representatives to collaborate in the mission of addressing healthcare disparities that constitute a major burden on patients, their families, and on public health. To support this mission, YCCI will also foster the development of careers in community-based research from a diverse group of young investigators and enhance the overall clinical research workforce. Project Summary/Abstract Page 177 Contact PD/PI: Smith, Brian Richard # ! ! % "# # " ! "#! !# ! & # # ! $ " ! " ! ! # ) # # % !" $ # " # # #! # ! ! # ! # #! " # " % ! # ! ' " % !" #(*" $#"# # $ # " # % ! # & # # "#! # & % # ("# # ! # ! # "("# # # ! " # $ # " & & ! & # # ! " # "# ! # $!# ! ! &# $ # " !( # " % % # % ! # % ! " # " "#! # " ! " " ! % # "# " # ! $# " # # # ! & ! ! "$ #" ! # # $ # " # ! # "("#