Yale Clinical and Translational Science Award

耶鲁临床与转化科学奖

• 批准号: 10415233
• 负责人: John H. Krystal
• 金额: $ 1073.77万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10415233
• 关键词: Address; Area; Beds; Bioethics; Bioinformatics; Biometry; Catchment Area; Clinical; Clinical Research; Clinical and Translational Science Awards; Collaborations; Communities; Connecticut; County; Data; Electronic Health Record; Environment; Ethics; Faculty; Family; Fellowship Program; Fostering; Functional disorder; Funding; Future; Generations; Genomics; Grant; Growth; Health; Health system; Healthcare; Healthcare Systems; Heart; Home; Hospitals; Image; Imprisonment; Improve Access; Industry; Informatics; Infrastructure; Interdisciplinary Study; International; Intervention; Investments; Learning; Link; Methodology; Mission; NCI Scholars Program; Outpatients; Patients; Pilot Projects; Public Health; Public Health Informatics; Randomized; Reproducibility; Research; Research Infrastructure; Research Personnel; Research Support; Research Training; Resources; Rhode Island; Role; Science; Scientific Advances and Accomplishments; Scientist; Shapes; Site; Special Population; Talents; Technology; Training; Training Programs; Translational Research; Translations; United States National Institutes of Health; Visit; Wood material; actionable mutation; base; bioimaging; career; career development; clinical care; clinical center; clinical investigation; community based research; data resource; exome sequencing; health care disparity; informatics infrastructure; innovation; insight; member; multiple omics; new technology; next generation; novel; patient population; personalized health care; personalized medicine; point of care; post-doctoral training; pre-doctoral; programs; recruit; research and development; translational impact; translational pipeline; translational scientist

Contact PD/PI: Smith, Brian Richard 1. Overall: Project Summary The Yale Center for Clinical Investigation (YCCI) was created in 2005 to advance Yale's clinical research mission. One year later, YCCI became the home of the Yale CTSA. At YCCIs inception, Yale was a national leader in T0-T2 translational research, basic/translational science training, and it supported distinctive fellowship programs such as the Robert Wood Johnson Clinical Scholars Program. Since then, the CTSA has had a transformative impact linking diverse components of the Yale community in T1-T4 research, providing the central infrastructure for the effective conduct of ethical, innovative, rigorous, and reproducible research, and in training the next generation of research leaders. By any metric of scale, breadth, quality, and impact, both the CTSA's research enterprise and its educational mission have been enormously successful for Yale. This renewal application does not simply seek to maintain excellence, but to enable YCCI to drive the continued transformation of the Yale T1-T4 translational research mission and its predoctoral and postdoctoral training mission and to promote collaboration across CTSA hubs. First, it will support informatics and computational advances that drive the emergence of a learning health system. In so doing, it will draw on the Yale New Haven Health System, a six-hospital 2,681-bed consortium that provides more than 2.4 million outpatient visits from patients from upper Westchester county, throughout Connecticut, and southern Rhode Island. It will also prepare young scientists to draw on this infrastructure to conduct research that influences the future of healthcare. Second, it will support technological and scientific advances in areas that will support the emergence of personalized healthcare, including multi-omics and imaging. YCCI will provide pilot grant support and training to foster the development of research careers and research teams that can deepen our insights into pathophysiology and build toward personalized treatments. Third, it will engage a broader and more diverse group of faculty, trainees, and community representatives to collaborate in the mission of addressing healthcare disparities that constitute a major burden on patients, their families, and on public health. To support this mission, YCCI will also foster the development of careers in community-based research from a diverse group of young investigators and enhance the overall clinical research workforce. Project Summary/Abstract Page 177 Contact PD/PI: Smith, Brian Richard # ! ! % "# # " ! "#! !# ! & # # ! $ " ! " ! ! # ) # # % !" $ # " # # #! # ! ! # ! # #! " # " % ! # ! ' " % !" #(*" $#"# # $ # " # % ! # & # # "#! # & % # ("# # ! # ! # "("# # # ! " # $ # " & & ! & # # ! " # "# ! # $!# ! ! &# $ # " !( # " % % # % ! # % ! " # " "#! # " ! " " ! % # "# " # ! $# " # # # ! & ! ! "$ #" ! # # $ # " # ! # "("#

联系PD/PI：Smith，Brian Richard 1。总体：项目摘要 耶鲁大学临床调查中心（YCCI）于2005年创建了耶鲁大学的临床研究 使命。一年后，YCCI成为耶鲁大学CTSA的故乡。耶鲁大学是耶鲁大学的成立 T0-T2转化研究，基础/转化科学培训的领导者，并支持独特的 奖学金计划，例如罗伯特·伍德·约翰逊（Robert Wood Johnson）临床学者计划。从那以后，CTSA有 在T1-T4研究中将耶鲁大学社区的各个组成部分联系起来具有变革性的影响，提供了 有效进行道德，创新，严格和可重复的研究的中央基础设施， 并在培训下一代研究领导者中。按任何规模，广度，质量和影响的指标， CTSA的研究企业及其教育任务在耶鲁大学都取得了巨大的成功。 此续签应用不仅仅是寻求维护卓越，而是使YCCI推动 耶鲁T1-T4转化研究任务及其前和博士后的继续转变 培训任务并促进跨CTSA枢纽的合作。首先，它将支持信息学和 驱动学习卫生系统出现的计算进步。这样，它将吸引 耶鲁纽黑文卫生系统，一个六院2,681张床位财团，提供超过240万 来自康涅狄格州上韦斯特切斯特县的患者的门诊就诊 岛。它还将使年轻科学家借鉴这种基础设施，以进行影响 医疗保健的未来。其次，它将支持支持该领域的技术和科学进步 个性化的医疗保健的出现，包括多词和成像。 YCCI将提供飞行员赠款支持 和培训以促进可以加深我们见解的研究职业和研究团队的发展 进入病理生理学并朝着个性化治疗迈进。第三，它将吸引更广泛的 多元化的教职员工，学员和社区代表，以合作为使命 医疗保健差异构成患者，家人和公共卫生的重大负担。到 支持这项任务，YCCI还将促进从社区研究中发展的职业 各种各样的年轻研究人员组，并增强了整体临床研究劳动力。 项目摘要/摘要页面177 联系PD/PI：Smith，Brian Richard ＃！ 呢 ％“＃＃”！ “＃！！＃！＆＃！$” 呢“！！＃）＃＃％！” $＃“＃＃！＃！！！＃！＃！ ＃！ “＃”％！ ＃！ '“％！” ＃（*“ $＃”＃＃$＃ “＃％！＃＆＃”＃！ ＃＆％＃（“＃＃！＃！＃！＃ ”（“＃＃！”＃$＃“＆＆！＆＃！”＃“＃！＃$！＃！！＆＃ $＃“！（＃“％％＃％！＃％！”＃“＃！＃”！ 呢％＃“＃”＃！ $＃“＃＃！＆！” $＃“！＃＃ $＃“＃！＃”（“＃）