UAB Center for AIDS Research (CFAR)

UAB 艾滋病研究中心 (CFAR)

• 批准号: 9761778
• 负责人: Michael S. Saag
• 金额: $ 254.96万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9761778
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Aging; Alabama; Area; Award; Basic Science; Behavioral; Behavioral Sciences; Biology; Budgets; Caring; Clinical; Clinical Data; Collaborations; Communication; Communities; Computerized Medical Record; Core Facility; Culture Techniques; Database Management Systems; Development; Discipline; Disease; Educational workshop; Effectiveness; Epidemiology; Evolution; Extramural Activities; Faculty; Faculty Recruitment; Flow Cytometry; Fostering; Funding; Grant; HIV; Human immunodeficiency virus test; Institutes; Interdisciplinary Study; International; Intervention; Intervention Studies; Investments; Leadership; Link; Location; Mentors; Methodology; Methods; Mission; Molecular Virology; NIH Grants and Contracts; Operations Research; Outcomes Research; Outsourcing; Pathogenesis; Peer Review; Prevention; Process; Productivity; Program Development; Publications; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Risk Assessment; Services; Southeastern United States; Specimen; Spirituality; Statistical Data Interpretation; Strategic Planning; Therapeutic; Tissue Procurements; Tissue Transplantation; Training; Training Support; Translational Research; Transplanted tissue; Treatment Efficacy; Underrepresented Minority; United States; United States National Institutes of Health; Woman; base; community science; innovation; interest; member; minority investigator; novel; population health; programs; recruit; service utilization; social stigma; transmission process; vaccine development; virus culture; working group

PROJECT SUMMARY Overall The mission of the UAB CFAR is to support the conduct of cutting-edge research in basic science, therapeutics, prevention, community engaged research, and clinical manifestations and pathogenesis of HIV and related disorders. Five core facilities provide vital support for the Center's principal thematic areas of its scientific agenda. To optimize our CFAR operation, an intensive strategic planning process has established efficiencies through streamlining its cores from 7 to 5, taking full advantage of existing services provided by other centers on campus, outsourcing under-utilized services, and allowing for investments in new areas (Specific Aims workshops, Transplant Tissue Procurement Facility, and Ending HIV in Alabama SWG). The Center includes 185 members from over 30 divisions and departments within UAB. Over the last 4 years, the UAB CFAR has enabled research leading to FRB / total funding of $21M / $66M. The majority (62%) was newly obtained in this budget period; 57% of these are related to basic science, 18% to population health prevention and treatment research, 22% to behavioral epi and intervention research, and 3% to community engaged research. Since our last renewal, the center has increased the number of young investigators supported by training awards from 7 to 16 (14 women; 5 under-represented minorities, URMs) and invested $1.9M in new-investigator pilot awards yielding $25M in outside funding. Overall, for our ROI in pilot funding is 13:1 in new extramural grants awarded. The Center helped recruit 45 new HIV/AIDS investigators in the last 4 years (17 external, 28 new to HIV research), of whom 21 are women and 5 URMs. Across all cores the CFAR supported 61 unique, NIH-funded projects (FRB) and 404 other NIH-funded projects, of which 309 were HIV-specific resulting in over 1000 HIV publications, and in the garnering of strong Institutional support. Over the next 5 years we will: (1) Continue to enhance the productivity of ongoing research programs by enabling interdisciplinary research through the provision of critical shared resource facilities and administrative and fiscal management support to Center investigators (2) Use robust strategic planning methods to identify new research opportunities and priorities that align with existing CFAR programs and foster new research programs where none are in existence, but where faculty interest is evident; (3) Stimulate the entry of early stage and established faculty into HIV/AIDS research programs through mentoring programs for young investigators and through a robust, peer-reviewed Developmental Grants Program; (4) Provide a central focus for HIV/AIDS research activities at UAB that emphasize effective communication and collaboration among CFAR members with the wider HIV/AIDS research community; and (5) Promote faculty recruitment and program development in areas that reflect the ongoing evolution of HIV/AIDS research in Alabama, the United States, and around the world. The UAB CFAR will foster HIV/AIDS research that has high local, national, and international impact and in so doing will promote the NIH priorities of innovation and effectiveness in AIDS treatment and prevention.

项目总结 总括 UAB CFAR的使命是支持基础科学、治疗学、 艾滋病毒及其相关疾病的预防、社区参与研究、临床表现和发病机制 精神错乱。五个核心设施为中心科学议程的主要主题领域提供了至关重要的支持。 为了优化我们的CFAR运作，密集的战略规划过程通过以下方式提高了效率 将其核心从7个精简到5个，充分利用校园其他中心提供的现有服务， 外包未得到充分利用的服务，并允许在新领域进行投资(具体目标研讨会， 移植组织采购设施，以及在阿拉巴马州终止艾滋病毒)。该中心有185名成员 来自UAB内的30多个司和部门。在过去的4年里，UAB CFAR使研究成为可能 导致FRB/总资金为2100万美元/6600万美元。大多数(62%)是在本预算期间新获得的； 其中57%与基础科学有关，18%与人群健康预防和治疗研究有关，22%与 行为EPI和干预研究，3%用于社区参与研究。自从我们上次续签以来， 该中心将由培训奖支持的年轻调查员人数从7人增加到16人(14名妇女； 5个代表不足的少数族裔(URM)，并投资190万美元获得新的调查员试点奖项，获得2500万美元的 外部资金。总体而言，我们在试点资金中的投资回报率是新发放的校外赠款的13：1。该中心帮助了 在过去4年中招聘了45名新的艾滋病毒/艾滋病调查员(17名外部调查员，28名艾滋病毒研究新手)，其中21名是 女性和5个URM。在所有核心中，CFAR支持了61个由NIH资助的独特项目(FRB)和404个其他项目 美国国立卫生研究院资助的项目，其中309个是艾滋病毒专题项目，产生了1000多份艾滋病毒出版物，并正在收集 强有力的制度支持。在接下来的5年里，我们将： (1)通过支持跨学科研究，继续提高正在进行的研究计划的生产力 通过提供关键的共享资源设施以及行政和财政管理支助， 中心调查人员(2)使用强有力的战略规划方法来确定新的研究机会和 与现有的CFAR计划保持一致的优先事项，并在尚不存在的地方培育新的研究计划， 但在教师明显感兴趣的地方；(3)鼓励早期和成熟的教师进入艾滋病毒/艾滋病领域 通过为年轻研究人员提供指导计划以及通过强有力的同行评议 发展赠款方案；(4)为联合大学的艾滋病毒/艾滋病研究活动提供中心重点， 强调CFAR成员与更广泛的艾滋病毒/艾滋病研究之间的有效沟通和合作 社区；以及(5)促进教师招聘和项目发展，以反映正在进行的 阿拉巴马州、美国和世界各地艾滋病毒/艾滋病研究的进展。 UAB CFAR将促进具有高度地方、国家和国际影响的艾滋病毒/艾滋病研究，因此 这样做将促进NIH在艾滋病治疗和预防方面的创新和有效性的优先事项。