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Retinal/choroidal imaging with transcranial back-illumination

经颅背照式视网膜/脉络膜成像

基本信息

批准号：
9762120
负责人：
Jerome Mertz
金额：
$ 20.63万
依托单位：
BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9762120
关键词：
Age related macular degeneration Appearance Attenuated Back Biological Markers Cardiac Choroid Clinic Clinical Color Cornea Data Devices Diagnosis Diffuse Eye Fundus Fundus photography Geometry Glare Goals Hemoglobin Human Image Imagery Imaging technology Light Lighting Lipids Macular degeneration Maps Medical center Melanins Methods Modality Mydriasis New England Ophthalmoscopes Optic Disk Optical Coherence Tomography Optics Oxygen Penetration Performance Process Property Pupil Records Recovery Rest Retina Retinal Stimulus Structure Structure of retinal pigment epithelium System Techniques Tissues Uncertainty absorption base bone chromophore contrast imaging cranium design design and construction early screening experience eye center fundus imaging hemodynamics imager imaging modality macula movie novel real time monitoring response retinal imaging screening sensor time use transmission process volunteer

项目摘要

ABSTRACT Human retinal imaging is conventionally performed with a fundus camera, which sends light into the subject’s eye and records images of the light reflected from the retina. Our goal is to develop an alternative imaging strategy based on light delivered transcranially through the subject’s temple. The light diffuses through the bone and illuminates the retina not from the front, as in a standard fundus camera, but rather mostly from the back. As such, we image light transmitted through the retina rather than reflected from the retina. In addition to being glare-free and allowing deeper image penetration well into the choroid, we hypothesize that transmitted-light imaging reveals qualitatively different tissue structure than reflected-light imaging. Our strategy will be compatible with existing fundus cameras, enabling transmission and reflection modalities to be operated quasi-simultaneously, allowing a direct comparison of the two modalities and a potential fusion of the information they provide. Specifically, we propose to equip our device with eight different LED illumination wavelengths, any two of which can be operated simultaneously, from which we propose to identify a variety of chromophore distributions such as oxy- and deoxy-hemoglobin and melanin. We hypothesize that such chromophore mapping over extended depths will provide valuable information useful for the potential diagnosis and study of macular degeneration, and for the real-time monitoring of hemodynamics. To gauge the performance of our device and its potential utility in the clinic, we have enlisted the help of Dr. Elias Reichel at the Tufts Medical Center, who has clinical experience with both fundus and OCT imaging.

摘要人类视网膜成像常规上用眼底照相机执行，眼底照相机将光发送到视网膜。并记录从视网膜反射的光的图像。我们的目标是开发一种替代的成像策略，其基于通过受试者的寺光线通过骨骼扩散并照亮视网膜，而不是从前面，就像在一个标准眼底照相机，但主要是从后面。因此，我们将透射的光通过视网膜而不是从视网膜反射。除了无眩光外，允许更深的图像穿透以及进入脉络膜，我们假设，成像揭示了与反射光成像不同的组织结构。我们的战略将与现有眼底照相机兼容，实现透射和反射模式准同时操作，允许两种模式的直接比较，它们所提供的信息的潜在融合。具体来说，我们建议为我们的设备配备八种不同的LED照明波长，其中任何两个可以同时操作，我们建议从中识别各种发色团分布，如氧合血红蛋白和脱氧血红蛋白以及黑色素。我们假设这种延伸深度的发色团映射将提供有用的有价值的信息，用于黄斑变性的潜在诊断和研究，血液动力学的。为了评估我们的设备的性能及其在临床上的潜在效用，我们已经得到了塔夫茨医疗中心的埃利亚斯·赖谢尔博士的帮助，他有临床具有眼底和OCT成像经验。