Speckle-free phase-contrast ultrasound imaging

无散斑相衬超声成像

• 批准号: 10018054
• 负责人: Jerome Mertz
• 金额: $ 20.63万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10018054
• 关键词: Acoustics; Adoption; Algorithms; Anesthesiology; Awareness; Back; Boston; Cardiology; Clinical; Detection; Development; Devices; Discipline of obstetrics; Emergency Medicine; Epithelial; Epithelium; Equation; Frequencies; Frustration; Future; Gastroenterology; Geometry; Goals; Gynecology; Human; Image; Imaging Techniques; Label; Lighting; Medical; Medical Imaging; Medical center; Methods; Microscopy; Modality; Modification; Neonatology; Neurology; Ophthalmology; Optics; Organ; Otolaryngology; Penetration; Performance; Phase; Pulmonology; Radiology Specialty; Reporting; Research; Resolution; Rest; Sampling; Source; Structure; System; Techniques; Thick; Time; Tissue imaging; Tissues; Transducers; Translating; Ultrasonography; Universities; Urology; Work; base; clinical development; clinical imaging; cost effective; experience; health care delivery; imaging modality; imaging system; improved; medical schools; millimeter; new technology; optical imaging; photonics; professor; reconstruction; sound; technique development; tomography; transmission process

ABSTRACT Ultrasound (US) imaging is one of the most common methods of medical imaging, and has had tremendous impact in the practice and delivery of healthcare. Advantages of ultrasound imaging are that it is non-invasive, cost-effective, and provides images with penetration depths commensurate with human organ imaging. In this last regard, US imaging has a considerable advantage over optical imaging techniques, which are hampered by very poor depth penetration in comparison. This proposal rests on the fact that there is a close analogy between optical imaging and US imaging. We have recently developed a new optical microscopy technique called Oblique Back-illumination Microscopy (OBM) that provides DIC-like phase contrast in arbitrarily thick tissue. While OBM is a remarkably simple method to obtain fast, high resolution, label-free imaging of tissue structure, it is limited in depth penetration to about 100µm. Such limited depth penetration restricts the applicability of OBM to superficial imaging of epithelial tissue only. Motivated by the close analogy between optical and US imaging, we propose to extend the concept of OBM directly to acoustics, enabling the possibility of what we believe to be an entirely new modality of US imaging, called Oblique Backscattering Ultrasound (OBUS) imaging. Specifically, OBUS imaging is unusual in that it is based on the detection of transmitted rather than reflected sound, even though it is configured in a reflection geometry. As such, it can operate in arbitrarily thick tissue, thus differing from previous transmission US imaging techniques. Because it is based on phase contrast, OBUS imaging reveals fundamentally different sample features than standard echography. Moreover, OBUS imaging is speckle-free, which has been a long- standing challenge in US imaging. We propose to improve OBUS by combining it with a technique called Differential Aberration Imaging, enabling it to work with the same samples and with the same hardware as a conventional echographic US imaging. Information from both contrast modalities will be obtained simultaneously, and combined to enable augmented sample reconstruction. Our goal will be to lay the necessary groundwork for the future development of this new technology, which we believe represents a paradigm shift in US imaging that may have significant clinical impact.

抽象的 超声（美国）成像是最常见的医学成像方法之一，并且 在医疗保健的实践和提供方面的巨大影响。超声成像的优点是 非侵入性，具有成本效益，并提供与人体器官相称的渗透深度的图像 成像。在最后的这一方面，我们的成像比光学成像技术具有相当大的优势 相比之下，深度渗透率非常差。 该提议基于以下事实：光学成像与我们成像之间有一个密切的类比。我们 最近开发了一种新的光学显微镜技术，称为斜面显微镜 （OBM）在任意厚的组织中提供了DIC样相的对比。虽然OBM是一个非常简单的 获得快速，高分辨率，无标记的组织结构的方法，其深度渗透到 约100µm。如此有限的深度穿透限制了OBM对浅表成像的适用性 仅上皮组织。 通过光学和美国成像之间的密切类比，我们提出了扩展的概念 OBM直接发表声学，使我们认为这是我们全新的方式的可能性 成像，称为倾斜反向散射超声（OBUS）成像。具体而言，Obus成像在 它基于传输而不是反射声音的检测，即使它是在 反射几何形状。因此，它可以在任意厚的组织中工作，因此与以前的传播不同 我们的成像技术。因为它基于相比，所以OBUS成像揭示了根本不同的 样本特征比标准的传动学。此外，Obus成像不含斑点，这是一个长期的 我们成像中的坚定挑战。 我们建议通过将其与一种称为差异成像的技术相结合来改善OBU， 使其能够与相同的样本和与传统的Echographicing US一起使用相同的硬件 成像。将简单地获得来自两种对比方式的信息，并合并以启用 增强样品重建。我们的目标是为未来奠定必要的基础 这项新技术的开发，我们认为这代表了我们成像的范式转变 具有重大的临床影响。