COBRE Phase III Transitional Center

COBRE 三期过渡中心

• 批准号: 9764413
• 负责人: Soumyajit Majumdar
• 金额: $ 107.93万
• 依托单位: UNIVERSITY OF MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9764413
• 关键词: Agonist; Antineoplastic Agents; Award; Cancer Control; Cannabinoids; Categories; Centers of Research Excellence; Cocaine Abuse; Collaborations; Communities; Core Facility; Development; Disease; Educational workshop; Ensure; Environment; Equipment; Etiology; Extramural Activities; Faculty; Functional disorder; Funding; Glaucoma; Goals; Grant; Growth; Home environment; Immune system; Industrialization; Infrastructure; Intellectual Property; Journals; Mentors; Mississippi; Modeling; Natural Products; Nausea and Vomiting; Nervous system structure; Neuraxis; Neuropharmacology; Neurosciences; Neurosciences Research; Patients; Peer Review; Pharmacy Schools; Phase; Pilot Projects; Publications; Published Comment; Publishing; Reporting; Research; Research Personnel; Research Project Grants; Role; Schools; Scientist; Structure; Teacher Professional Development; Techniques; Time; Training; USAID; Universities; Weight maintenance regimen; Work; Writing; cancer therapy; college; innovation; insight; instrument; mass spectrometer; member; methamphetamine abuse; multidisciplinary; nervous system disorder; non-cannabinoid; novel; programs; research and development; sigma receptors; sound; success; training opportunity

PROJECT SUMMARY/ABSTRACT The Center of Research Excellence in Natural Products Neuroscience (CORE-NPN) at The University of Mississippi School of Pharmacy (UM), initiated ten years ago through a COBRE grant, has developed a multidisciplinary team committed to evaluating the effects of natural products on the central nervous system (CNS). The Center now has the potential to develop and sustain an innovative and independently funded research center focused on treating disorders associated with the nervous system. Faculty in the Center and its academic home, the School of Pharmacy, have already reported groundbreaking observations on the roles of cannabinoids and non-cannabinoids in the etiology of weight control, the control of the immune system, treatment of cancer, control of nausea and vomiting in patients receiving anti-neoplastic treatment, glaucoma, and the development of sigma receptor agonists in the treatment of cocaine and methamphetamine abuse. Also, CORE- NPN-supported investigators have increased their competitiveness by attracting extramural funds and publishing in leading journals of neuroscience. The Center will continue to provide an excellent environment for junior and mid-level investigators through the Pilot Project Program. Investigators will work in close collaboration with leading national centers and scientists studying natural products to carry out the proposed projects that build on these novel insights into the pathophysiology of nervous system disorders. To achieve the goal of establishing an innovative and multidisciplinary Center focused on the use of natural products to manage neuropharmacological disorders, the following Specific Aims are proposed: Specific Aim 1: Administration. To enhance a sound administrative structure that offers strong mentoring for junior scientists, management of the Research Cores, workshops on grant writing/management (pre- and post-award), training in responsible conduct in research, intellectual property development, distinguished lectureship program, and promote the development of the CORE-NPN into an independent Center. Specific Aim 2: Research Core Facilities. To accelerate the research of the CORE-NPN and the associated community through state-of-the-art equipment, cutting-edge techniques, and scientific expertise. Specific Aim 3: Pilot Project Program (PPP). To advance an infrastructure of developmental programs that engage in basic, translational, and entrepreneurial research.

项目总结/摘要 自然产品神经科学卓越研究中心（CORE-NPN） 密西西比药学院（UM），十年前通过COBRE赠款发起，已经开发了一种 致力于评估天然产品对中枢神经系统的影响的多学科团队 （CNS）。该中心现在有潜力发展和维持一个创新的和独立资助的 该研究中心专注于治疗与神经系统相关的疾病。中心的教师及其 学术之家，药学院，已经报告了对药物作用的开创性观察， 大麻素和非大麻素在控制体重、控制免疫系统、治疗 控制接受抗肿瘤治疗的患者的恶心和呕吐，青光眼， 开发用于治疗可卡因和甲基苯丙胺滥用的σ受体激动剂。此外，核心- NPN支持的研究人员通过吸引校外资金和出版物来提高竞争力 发表在神经科学的主要期刊上。中心将继续为青少年提供良好的环境， 中级调查员通过试点项目计划。调查人员将密切合作， 领先的国家中心和科学家研究天然产品，以执行拟议的项目，建立在 这些对神经系统疾病的病理生理学的新见解。为实现建立 一个创新和多学科中心，专注于使用天然产品来管理 针对神经药理学疾病，提出了以下具体目的：具体目的1：给药。到 加强健全的行政结构，为初级科学家提供强有力的指导， 研究核心、赠款撰写/管理讲习班（赠款前和赠款后）、负责任行为培训 在科研、知识产权开发、卓越讲师计划等方面，促进发展 将CORE-NPN合并为一个独立中心。具体目标2：研究核心设施。加快 研究的核心-NPN和相关的社区通过国家的最先进的设备，尖端 技术和科学专业知识。具体目标3：试点项目方案。为了推进基础设施 从事基础、转化和创业研究的发展项目。