COBRE Phase III Transitional Center

项目摘要/摘要 加州大学天然产物神经科学卓越研究中心(CORE-NPN) 密西西比州药学院(UM)，十年前通过科布雷赠款发起，已经开发出一种 致力于评估天然产品对中枢神经系统影响的多学科团队 (CNS)。该中心现在有潜力开发和维持一个创新的和独立资助的 研究中心专注于治疗与神经系统相关的疾病。该中心的教职员工及其 学术之家，药学院已经报告了关于 大麻素与非大麻素在病因学中的体重控制、免疫系统控制、治疗 癌症、接受抗肿瘤治疗的患者的恶心和呕吐的控制、青光眼和 西格玛受体激动剂在治疗可卡因和甲基苯丙胺滥用中的开发。另外，核心- NPN支持的调查人员通过吸引外部资金和出版提高了竞争力 发表在神经科学的领先期刊上。中心将继续为青少年和青少年提供良好的环境 通过试点项目方案进行中层调查。调查人员将与以下机构密切合作 领导研究天然产品的国家中心和科学家执行拟议的项目 这些对神经系统疾病的病理生理学的新见解。为了实现建立 一个创新的多学科中心，专注于使用天然产品进行管理 针对神经药理学障碍，提出了以下具体目标：具体目标1：给药。至 加强健全的管理结构，为初级科学家提供强有力的指导，管理 研究核心、赠款编写/管理讲习班(授予前和授予后)、负责行为培训 在科研、知识产权开发、优秀讲师计划等方面，推动发展 将核心-NPN整合为一个独立的中心。具体目标2：研究核心设施。为了加速 通过最先进的设备、尖端技术研究核心-NPN及其相关社区 技术和科学专长。具体目标3：试点项目方案(PPP)。推进基础设施建设 从事基础研究、翻译研究和创业研究的发展项目。

PROJECT SUMMARY/ABSTRACT The Center of Research Excellence in Natural Products Neuroscience (CORE-NPN) at The University of Mississippi School of Pharmacy (UM), initiated ten years ago through a COBRE grant, has developed a multidisciplinary team committed to evaluating the effects of natural products on the central nervous system (CNS). The Center now has the potential to develop and sustain an innovative and independently funded research center focused on treating disorders associated with the nervous system. Faculty in the Center and its academic home, the School of Pharmacy, have already reported groundbreaking observations on the roles of cannabinoids and non-cannabinoids in the etiology of weight control, the control of the immune system, treatment of cancer, control of nausea and vomiting in patients receiving anti-neoplastic treatment, glaucoma, and the development of sigma receptor agonists in the treatment of cocaine and methamphetamine abuse. Also, CORE- NPN-supported investigators have increased their competitiveness by attracting extramural funds and publishing in leading journals of neuroscience. The Center will continue to provide an excellent environment for junior and mid-level investigators through the Pilot Project Program. Investigators will work in close collaboration with leading national centers and scientists studying natural products to carry out the proposed projects that build on these novel insights into the pathophysiology of nervous system disorders. To achieve the goal of establishing an innovative and multidisciplinary Center focused on the use of natural products to manage neuropharmacological disorders, the following Specific Aims are proposed: Specific Aim 1: Administration. To enhance a sound administrative structure that offers strong mentoring for junior scientists, management of the Research Cores, workshops on grant writing/management (pre- and post-award), training in responsible conduct in research, intellectual property development, distinguished lectureship program, and promote the development of the CORE-NPN into an independent Center. Specific Aim 2: Research Core Facilities. To accelerate the research of the CORE-NPN and the associated community through state-of-the-art equipment, cutting-edge techniques, and scientific expertise. Specific Aim 3: Pilot Project Program (PPP). To advance an infrastructure of developmental programs that engage in basic, translational, and entrepreneurial research.