Administrative Core

项目概要/摘要 自然产品神经科学卓越研究中心（CORE-NPN） 密西西比药学院（UM），十年前通过COBRE赠款发起，已经开发了一种 致力于评估天然产品对中枢神经系统的影响的多学科团队 （CNS）。该中心现在有潜力发展和维持一个创新的和独立资助的 该研究中心专注于治疗与神经系统相关的疾病。行政核心 CORE-NPN培养了一批科学家，致力于加强我们基础设施的竞争力， 在天然产物和神经药理学的界面上的翻译和创业研究项目。 行政核心将继续组织辅导支助、指导委员会会议， 外部咨询理事会（EAC）会议、杰出讲师系列、每月会议（专题讨论会- COBRE-Talks）、CORE-NPN年度专题讨论会、编写进度报告、审查试点项目 应用程序，预算管理方面的协助，以及与研究核心可能出现的冲突解决方案 使用.此外，行政核心将确保按服务收费的业务符合 大学政策，跟踪和监控核心使用，评估核心运营，组织年度核心研究 天，管理神经科学计划，促进与UM神经科学星座的合作，并建立 与IDEA和其他计划的合作伙伴关系。在建立了一批关键的调查人员之后， COBRE第一和第二阶段的核心-NPN，第三阶段的目标将是鼓励教师， 合并我们在天然产物和神经药理学的研究计划，并促进P01/P50/U19赠款 应用.将对行政核心的活动进行结构调整，使核心-NPN成为一个成熟的 可持续中心。帮助实现我们目标的具体目标是：具体目标1：增强声音 通过合作和培养研究工作组，提高核心-NPN教师的竞争力。 这将促进新研究的发展，并促进CORE-NPN科学家之间的互动 以及其他IDEA项目的教职员工。具体目标2：加快有前途的 通过试点项目计划，使用严格的指导核心-NPN的教师。最好的新想法， 来自具体目标1的人将获得种子资金，以支持生成关键数据， 竞争性资助申请或进一步开发临床或商业产品。具体目标3：推进 研究核心的基础设施，以丰富我们的研究工作，并加强核心 持续发展研究核心将得到支持，以确保它们是最先进的设施。这将是 在机构支持和计划的外联方案以及期间和之后的合作下完成 第三阶段。

PROJECT SUMMARY/ABSTRACT The Center of Research Excellence in Natural Products Neuroscience (CORE-NPN) at The University of Mississippi School of Pharmacy (UM), initiated ten years ago through a COBRE grant, has developed a multidisciplinary team committed to evaluating the effects of natural products on the central nervous system (CNS). The Center now has the potential to develop and sustain an innovative and independently funded research center focused on treating disorders associated with the nervous system. The Administrative Core of the CORE-NPN has cultivated a team of scientists engaged in strengthening the competitiveness of our basic, translational, and entrepreneurial research projects at the interface of natural products and neuropharmacology. The Administrative Core will continue to organize mentoring support, Steering Committee (SC) meetings, External Advisory Council (EAC) meetings, the Distinguished Lectureship Series, the monthly meetings (Ignite- COBRE-Talks), the Annual CORE-NPN Symposium, preparation of Progress Reports, review of Pilot Project Applications, assistance in management of budgets, and conflict resolution that might arise with Research Core usage. Additionally, the Administrative Core will ensure that fee-for-service operations are consistent with University policies, track and monitor Core usage, evaluate Core operations, organize Annual Core Research Days, manage the Voucher program, foster collaborations with the UM Neuroscience Constellation and build partnerships with IDeA and other programs. Having built a critical mass of investigators who were funded during COBRE Phases I and II of the CORE-NPN, the objectives of Phase III will be to encourage faculty members to coalesce our research program in natural products and neuropharmacology and foster P01/P50/U19 grant applications. The activities of the Administrative Core will be structured so the CORE-NPN becomes a mature and sustainable Center. The specific aims to help accomplish our goals are: Specific Aim 1: To enhance sound competitiveness of the CORE-NPN faculty through collaborations and by fostering research working groups. This will facilitate the development of novel research and foster interactions among the CORE-NPN scientists and with faculty members of other IDeA programs. Specific Aim 2: To accelerate the research of promising faculty of the CORE-NPN through the Pilot Project Program using rigorous mentoring. The best novel ideas that come from Specific Aim 1 will be provided seed money to support the generation of critical data to support new competitive grant applications or to further develop a clinical or commercial product. Specific Aim 3: To advance an infrastructure of the Research Cores in order to enrich our research efforts and to reinforce the Cores sustainability. Research Cores will be supported to ensure they are state-of-the-art facilities. This will be accomplished with institutional support and planned outreach programs and collaborations during and beyond Phase III.