Integrative Center for Environmental Microbiomes and Human Health

项目摘要--总体 建议的Cobre计划的目标是创建一个环境综合中心 微生物群与人类健康(ICEMHH)--对2016年国家 微生物组倡议(NMI)。NMI的构思是通过认识到人类都是相互联系的 依赖于组成地球微生物群落的微生物群落，在环境中 以及人类的身体。美国国立卫生研究院在资助这项工作中发挥着核心作用，“..特别强调 多生态系统比较研究，以及探索和理解设计调查的新工具 微生物组“[美国国立卫生研究院人类微生物组项目]。ICEMHH的重点是微生物之间的界面 环境和人类健康，并从最先进的“组学”方法到生态分析和 预测性模型。夏威夷大学ʻI为微生物组研究带来了三个令人信服的优势： 夏威夷群岛独特的易驯化和可伸缩的景观，一支非常合格的生物学教师， 包括最近聘用的、专注于微生物组、终身教职、初级教授和 致力于岛上居民的多样性。作为地球上最多样化的生物群，HawaiʻI 为研究生态梯度对人类健康的影响提供了机会，从山到海，以及 在城市和农村环境中都是如此。拟议的项目旨在解决两个关键和相互交织的健康问题 问题：环境恶化，以及目前由昆虫媒介传播的疾病的传播。在这 在此背景下，拟议的研究工作将：(I)探讨接触致病菌对人类健康的影响 环境中的微生物；(2)检查昆虫媒介的微生物群如何影响它们的传播 Oʻahu岛微观世界中的疾病；以及，(Iii)利用无脊椎动物模型提供对 微生物群促进健康的基本细胞、遗传和分子机制。就这样， 该中心将为夏威夷ʻI及以后的州做出持久的贡献。

Project Summary – OVERALL The goal of the proposed COBRE program is to create an Integrative Center for Environmental Microbiomes and Human Health (ICEMHH) in response to the 2016 announcement of the National Microbiome Initiative (NMI). The NMI was conceived through the recognition that humans are both connected to and reliant upon the microbial communities that constitute the Earth's microbiomes, in the environment as well as the human body. The NIH plays a central role in funding this effort, “..with a particular emphasis on multi-ecosystem comparison studies, and investigation into the design of new tools to explore and understand microbiomes” [NIH Human Microbiome Project]. The focus of ICEMHH is the interface between the microbial environment and human health, and spans state-of-the-art `-omics' methods to ecological analyses and predictive models. The University of Hawaiʻi brings three compelling strengths to microbiome research: the uniquely tractable and scalable landscape of the Hawaiian Islands, an exceptionally qualified biology faculty, including an integrated cohort of recently hired, microbiome-focused, tenure-track, junior professors, and a dedication to the diversity of people that live on the Islands. As the most diverse biome on Earth, Hawaiʻi offers the opportunity to study the effects of ecological gradients on human health, from mountain to sea, and in both urban and rural settings. The proposed projects aim to address two critical and intertwined health problems: the deteriorating environment, and the current spread of insect-vector borne diseases. In this context, proposed research efforts will (i) explore how human health is impacted by exposure to pathogenic microbes in the environment; (ii) examine how the microbiomes of insect vectors affect their transmission of disease within the microcosm of the island of Oʻahu; and, (iii) exploit invertebrate models to provide insight into the underlying cellular, genetic and molecular mechanisms by which microbiomes confer health. In this way, the Center will provide lasting contributions to the State of Hawaiʻi, and beyond.