Chemistry & DMPK Core

化学

• 批准号: 9764416
• 负责人: John M Rimoldi
• 金额: $ 24.26万
• 依托单位: UNIVERSITY OF MISSISSIPPI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9764416
• 关键词: Acute; Binding Proteins; Centers of Research Excellence; Characteristics; Chemicals; Chemistry; Collaborations; Consultations; Core Facility; Development; Disease; Drug Kinetics; Evaluation; Fee-for-Service Plans; Formulation; Funding; Goals; Grant; Health Services Accessibility; In Vitro; Infrastructure; Lead; Leadership; Mississippi; Modeling; Modification; Monitor; Natural Products; Nervous system structure; Neuraxis; Neurosciences; Pharmaceutical Chemistry; Pharmacologic Substance; Pharmacy Schools; Phase; Positioning Attribute; Productivity; Reaction; Research; Research Personnel; Research Support; Resource Sharing; Resources; Role; Route; S Phase; Scientist; Services; Solid; Solubility; Structure; Structure-Activity Relationship; Surveys; Synthesis Chemistry; Techniques; Technology; Training; Universities; Validation; analytical method; base; drug development; drug discovery; drug metabolism; experience; flexibility; improved; in vivo; innovation; instrumentation; lead optimization; method development; multidisciplinary; outreach; programs; scale up; small molecule; training opportunity

PROJECT SUMMARY/ABSTRACT The Center of Research Excellence in Natural Products Neuroscience (CORE-NPN) at The University of Mississippi School of Pharmacy (UM), initiated ten years ago through a COBRE grant, has developed a multidisciplinary team committed to evaluating the effects of natural products on the central nervous system (CNS). The Center now has the potential to develop and sustain an innovative and independently funded research center focused on treating disorders associated with the nervous system. Medicinal chemistry, drug metabolism, and pharmacokinetics (DMPK) are vital components of the iterative cycle of drug discovery, both embedded in hit-to-lead and lead optimization stages. The Chemistry/DMPK Research Core of the COBRE CORE-NPN program represents a shared core facility with the goal of serving biomedical investigators/users with consultation and specialized services and training in synthetic medicinal chemistry and DMPK as broadly defined within the NPN program. This Core is positioned to become a leader in synthesis, analysis, and early- stage DMPK evaluation of natural product and synthetic small-molecule drug discovery and development campaigns by accomplishing the following Specific Aims: (1) To strengthen the Chemistry/DMPK Research Core by providing users with enhanced services, access, and training in state-of-the-art instrumentation, specialized techniques, and scientific expertise; (2): To advance an infrastructure of developmental services to facilitate COBRE CORE-NPN research; (3): To accelerate a long-term plan for sustainability of the Core through expansion of the user base, research partnerships and collaborations, integration of a fee-for-service structure, institutional support, and adaptation to changes by monitoring the needs of the users. These aims will facilitate the transition of the Chemistry-DMPK Core into a fully self-sustained facility providing specialized research services and training opportunities essential in supporting investigators and bridging the drug discovery gap by providing users with consultation, training, and services in medicinal chemistry/DMPK, helping to alleviate the bottleneck associated with compound acquisition and evaluation.

项目概要/摘要 英国大学天然产物神经科学卓越研究中心 (CORE-NPN) 密西西比药学院 (UM) 十年前通过 COBRE 资助发起，开发了一种 多学科团队致力于评估天然产物对中枢神经系统的影响 （中枢神经系统）。该中心现在有潜力发展和维持一个创新的、独立资助的 研究中心专注于治疗与神经系统相关的疾病。药物化学、药物 代谢和药代动力学 (DMPK) 是药物发现迭代周期的重要组成部分， 嵌入到先导化合物和先导化合物优化阶段。 COBRE 的化学/DMPK 研究核心 CORE-NPN 计划代表一个共享核心设施，旨在为生物医学研究人员/用户提供服务 广泛提供合成药物化学和 DMPK 方面的咨询、专业服务和培训 NPN 程序中定义。该核心定位于成为综合、分析和早期领域的领导者 天然产物和合成小分子药物发现和开发的阶段 DMPK 评价 通过实现以下具体目标来开展活动： (1) 加强化学/DMPK 研究 核心是为用户提供最先进仪器的增强服务、访问和培训， 专业技术和科学专业知识； (2)：推进发展服务基础设施 促进 COBRE CORE-NPN 研究； (3)：通过以下方式加快核心可持续发展的长期计划： 扩大用户群、研究伙伴关系和协作、整合按服务收费的结构， 机构支持，并通过监测用户的需求来适应变化。这些目标将有利于 将化学-DMPK 核心转变为提供专业研究的完全自我维持的设施 服务和培训机会对于支持研究人员和缩小药物发现差距至关重要 为用户提供药物化学/DMPK方面的咨询、培训和服务，帮助缓解 与化合物获取和评估相关的瓶颈。