2019 Cannabinoid Function in the CNS GRC & GRS

2019 大麻素在 CNS GRC 中的功能

• 批准号: 9891042
• 负责人: Sachin Patel
• 金额: --
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9891042
• 关键词: 12 year old; 2-arachidonylglycerol; American; Anxiety; Area; Atmosphere; Award; Biological; Biology; Brain; Budgets; CNR1 gene; CNR2 gene; Cannabinoids; Cannabis; Cognition Disorders; Collaborations; Communities; Data; Development; Endocannabinoids; Financial Support; Fostering; Functional disorder; Funding; Future; General Population; Health; Homeostasis; Learning; Letters; Ligands; Link; Memory; Mental Depression; Mental Health; Mentors; Motor; Movement; National Institute of Drug Abuse; Nature; Neurobiology; Obesity; Oral; Physiological; Physiological Processes; Physiology; Plants; Play; Process; Program Development; Publishing; Regulation; Reporting; Research; Rewards; Role; Science; Scientist; Senior Scientist; Signal Transduction; Social Functioning; System; Tetrahydrocannabinol; Therapeutic; Therapeutic Effect; Time; United States; Woman; Work; addiction; anandamide; base; cannabinoid receptor; career development; career networking; data exchange; immune function; interest; marijuana use; meetings; member; neuropsychiatric disorder; next generation; novel strategies; pre-doctoral; programs; public health relevance; receptor; symposium

PROJECT SUMMARY Cannabinoid signaling in the CNS is composed of Cannabinoid receptors CB1 and CB2 and their cognate exogenous and endogenous ligands. Cannabinoid signaling is widely distributed throughout the CNS and it is implicated in a wide variety of important neurobiological processes including reward signaling and addiction, regulation of energy homeostasis, learning and memory, motor function, anxiety, and social function. Therefore, understanding the neurobiology of cannabinoid signaling could have broad implications for physiological CNS function and the pathophysiology of neuropsychiatric disorders. The Gordon Research Conference (GRC) on “Cannabinoid Functions in the CNS” and its associated Gordon Research Seminar (GRS) represent the quintessential scientific forums in the field of cannabinoid function in the CNS. This GRC meeting has a strong reputation for attracting the most active and renowned scientists in the field and it is the “must attend” meeting for trainees aiming to become the next generation of cannabinoid neuroscientists. In this renewal application, we request continued financial support to partially cover expenses for predoctoral and postdoctoral trainees to attend the 2019 and 2021 “Cannabinoid Functions in the CNS” GRS/GRC meetings. The primary aims of this conference are: 1) To provide outstanding scientific programs in the traditions and spirit of the Gordon Research Conferences. These include an emphasis on cutting-edge unpublished data by leaders in the field including a Nobel laureate, who has already agreed to present new work; a community atmosphere that fosters informal discussion and stimulates new collaborations, and on inclusion of plenary speakers outside of the field that could stimulate new areas of cannabinoid research, and 2) To foster the development of young scientists and trainees in the field. This will be executed primarily via organization of the GRS focused on increasing professional networks of young scientists, providing a venue for oral scientific presentation for trainees, and organization of career development seminars. A second and novel approach for this meeting will be the implementation of a mentoring system during the GRC to increase 1:1 interactions between trainees and senior scientists in the field. The “Cannabinoid Functions in the CNS” GRS/GRC is widely regarded as the pinnacle of meetings in the cannabinoid field and has several unique qualities including a 1) focus on the CNS, which is not present at any other Cannabinoid centered meeting, 2) strong emphasis on cutting-edge unpublished data, 3) continuing commitment to trainees through organization of the GRS, trainee mentoring program, and career development panels including “Women in Science” and “Publishing 101 Q&A,” for example. Discussions/debates focused on controversial topics will be new additions to this funding cycle.

项目摘要 中枢神经系统中的大麻素信号传导由大麻素受体CB1和CB2及其同源组成 外源和内源配体。大麻素信号传导广泛分布在整个中枢神经系统中，IT 与各种重要的神经生物学过程有关，包括奖励信号和 成瘾，能量稳态的调节，学习和记忆，运动功能，焦虑和社交 功能。因此，了解大麻素信号的神经生物学可能具有广泛的影响 用于身体中枢神经系统功能和神经精神疾病的病理生理学。戈登研究 会议（GRC）关于“中枢神经系统中的大麻素功能”及其相关的戈登研究研讨会 （GRS）代表了CNS中大麻素功能领域的典型科学论坛。这 GRC会议因吸引该领域最活跃和著名的科学家而闻名 这是学员的“必须参加”会议，目的是成为下一代大麻素 神经科学家。在此续签申请中，我们要求继续进行财政支持以部分覆盖 前注重和博士后学员参加2019年和2021年的费用 CNS” GRS/GRC会议的功能。本次会议的主要目的是：1）提供 戈登研究会议的传统和精神的杰出科学计划。这些 包括强调该领域领导人的前沿未发表的数据，包括诺贝尔奖获得者 谁已经同意提出新作品；一种促进非正式讨论和的社区氛围 刺激新的合作，并在现场外包含全体扬声器时，可以刺激 大麻素研究的新领域，以及2）促进年轻科学家和培训的发展 场地。这将主要通过组织的组织致力于增加专业网络 年轻科学家的摄于培训的口头科学演讲的场所和职业组织 发展中心。这次会议的第二种新颖的方法将是实施 在GRC期间指导系统以增加培训与高级科学家之间的1：1相互作用 场地。 “中枢神经系统中的大麻素功能” GRS/GRC被广泛认为是会议的顶峰 大麻素领域，具有多种独特的品质，包括a 1）专注于CNS，这不存在 在任何其他以大麻素为中心的会议上，2）非常重视尖端未发表的数据，3） 通过组织，学员心理计划和职业的组织继续致力于受训者 例如，开发小组包括“科学女性”和“出版101个问答”。 讨论/辩论集中在有争议的主题上将是此资助周期的新补充。