2019 Cannabinoid Function in the CNS GRC & GRS

项目总结 中枢神经系统中的大麻素信号由大麻素受体CB1和CB2及其同源物组成 外源和内源配体。大麻素信号广泛分布于中枢神经系统，它 与多种重要的神经生物学过程有关，包括奖赏信号和 成瘾、能量稳态调节、学习和记忆、运动功能、焦虑和社交 功能。因此，了解大麻素信号的神经生物学可能具有广泛的意义。 用于生理中枢神经系统功能和神经精神障碍的病理生理学。戈登研究 “大麻在中枢神经系统中的作用”会议(GRC)及其相关的戈登研究研讨会 (GRS)代表了中枢神经系统大麻素功能领域的典型科学论坛。这 GRC会议因吸引了该领域最活跃和最知名的科学家而享有盛誉 这是旨在成为下一代大麻类药物的受训者必须参加的会议 神经学家。在此续订申请中，我们请求继续提供财政支持，以部分覆盖 博士后和博士后学员参加2019年和2021年“大麻素”培训的费用 在CNS“GRS/GRC会议”中的职能。这次会议的主要目的是：1)提供 戈登研究会议的传统和精神中的杰出科学计划。这些 包括一位诺贝尔奖获得者在内的该领域领导人对尖端未发表数据的强调， 世卫组织已同意提出新的工作；促进非正式讨论和 鼓励新的合作，以及吸收外地的全体发言者，这可能会刺激 大麻素研究的新领域，以及2)促进青年科学家和受训人员在 菲尔德。这将主要通过以增加专业网络为重点的GRS组织来执行 青年科学家，为受训人员提供口头科学报告的场所，并组织职业生涯 发展研讨会。本次会议的第二个和新的方法将是实施 GRC期间的指导系统，以增加受训者和高级科学家之间的1：1互动 菲尔德。“中枢神经系统中的大麻功能”GRS/GRC被广泛认为是#年会议的顶峰 大麻素领域，并有几个独特的特点，包括1)专注于中枢神经系统，这是不存在的 在任何其他以大麻素为中心的会议上，2)强烈强调前沿未发表的数据，3) 通过组织GRS、学员指导计划和职业生涯，继续致力于学员 例如，发展小组包括“科学中的女性”和“出版101个问答”。 集中讨论有争议的主题的讨论/辩论将是这一供资周期的新成员。

PROJECT SUMMARY Cannabinoid signaling in the CNS is composed of Cannabinoid receptors CB1 and CB2 and their cognate exogenous and endogenous ligands. Cannabinoid signaling is widely distributed throughout the CNS and it is implicated in a wide variety of important neurobiological processes including reward signaling and addiction, regulation of energy homeostasis, learning and memory, motor function, anxiety, and social function. Therefore, understanding the neurobiology of cannabinoid signaling could have broad implications for physiological CNS function and the pathophysiology of neuropsychiatric disorders. The Gordon Research Conference (GRC) on “Cannabinoid Functions in the CNS” and its associated Gordon Research Seminar (GRS) represent the quintessential scientific forums in the field of cannabinoid function in the CNS. This GRC meeting has a strong reputation for attracting the most active and renowned scientists in the field and it is the “must attend” meeting for trainees aiming to become the next generation of cannabinoid neuroscientists. In this renewal application, we request continued financial support to partially cover expenses for predoctoral and postdoctoral trainees to attend the 2019 and 2021 “Cannabinoid Functions in the CNS” GRS/GRC meetings. The primary aims of this conference are: 1) To provide outstanding scientific programs in the traditions and spirit of the Gordon Research Conferences. These include an emphasis on cutting-edge unpublished data by leaders in the field including a Nobel laureate, who has already agreed to present new work; a community atmosphere that fosters informal discussion and stimulates new collaborations, and on inclusion of plenary speakers outside of the field that could stimulate new areas of cannabinoid research, and 2) To foster the development of young scientists and trainees in the field. This will be executed primarily via organization of the GRS focused on increasing professional networks of young scientists, providing a venue for oral scientific presentation for trainees, and organization of career development seminars. A second and novel approach for this meeting will be the implementation of a mentoring system during the GRC to increase 1:1 interactions between trainees and senior scientists in the field. The “Cannabinoid Functions in the CNS” GRS/GRC is widely regarded as the pinnacle of meetings in the cannabinoid field and has several unique qualities including a 1) focus on the CNS, which is not present at any other Cannabinoid centered meeting, 2) strong emphasis on cutting-edge unpublished data, 3) continuing commitment to trainees through organization of the GRS, trainee mentoring program, and career development panels including “Women in Science” and “Publishing 101 Q&A,” for example. Discussions/debates focused on controversial topics will be new additions to this funding cycle.