2019 Cannabinoid Function in the CNS GRC & GRS

2019 大麻素在 CNS GRC 中的功能

• 批准号: 9891042
• 负责人: Sachin Patel
• 金额: --
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9891042
• 关键词: 12 year old; 2-arachidonylglycerol; American; Anxiety; Area; Atmosphere; Award; Biological; Biology; Brain; Budgets; CNR1 gene; CNR2 gene; Cannabinoids; Cannabis; Cognition Disorders; Collaborations; Communities; Data; Development; Endocannabinoids; Financial Support; Fostering; Functional disorder; Funding; Future; General Population; Health; Homeostasis; Learning; Letters; Ligands; Link; Memory; Mental Depression; Mental Health; Mentors; Motor; Movement; National Institute of Drug Abuse; Nature; Neurobiology; Obesity; Oral; Physiological; Physiological Processes; Physiology; Plants; Play; Process; Program Development; Publishing; Regulation; Reporting; Research; Rewards; Role; Science; Scientist; Senior Scientist; Signal Transduction; Social Functioning; System; Tetrahydrocannabinol; Therapeutic; Therapeutic Effect; Time; United States; Woman; Work; addiction; anandamide; base; cannabinoid receptor; career development; career networking; data exchange; immune function; interest; marijuana use; meetings; member; neuropsychiatric disorder; next generation; novel strategies; pre-doctoral; programs; public health relevance; receptor; symposium

PROJECT SUMMARY Cannabinoid signaling in the CNS is composed of Cannabinoid receptors CB1 and CB2 and their cognate exogenous and endogenous ligands. Cannabinoid signaling is widely distributed throughout the CNS and it is implicated in a wide variety of important neurobiological processes including reward signaling and addiction, regulation of energy homeostasis, learning and memory, motor function, anxiety, and social function. Therefore, understanding the neurobiology of cannabinoid signaling could have broad implications for physiological CNS function and the pathophysiology of neuropsychiatric disorders. The Gordon Research Conference (GRC) on “Cannabinoid Functions in the CNS” and its associated Gordon Research Seminar (GRS) represent the quintessential scientific forums in the field of cannabinoid function in the CNS. This GRC meeting has a strong reputation for attracting the most active and renowned scientists in the field and it is the “must attend” meeting for trainees aiming to become the next generation of cannabinoid neuroscientists. In this renewal application, we request continued financial support to partially cover expenses for predoctoral and postdoctoral trainees to attend the 2019 and 2021 “Cannabinoid Functions in the CNS” GRS/GRC meetings. The primary aims of this conference are: 1) To provide outstanding scientific programs in the traditions and spirit of the Gordon Research Conferences. These include an emphasis on cutting-edge unpublished data by leaders in the field including a Nobel laureate, who has already agreed to present new work; a community atmosphere that fosters informal discussion and stimulates new collaborations, and on inclusion of plenary speakers outside of the field that could stimulate new areas of cannabinoid research, and 2) To foster the development of young scientists and trainees in the field. This will be executed primarily via organization of the GRS focused on increasing professional networks of young scientists, providing a venue for oral scientific presentation for trainees, and organization of career development seminars. A second and novel approach for this meeting will be the implementation of a mentoring system during the GRC to increase 1:1 interactions between trainees and senior scientists in the field. The “Cannabinoid Functions in the CNS” GRS/GRC is widely regarded as the pinnacle of meetings in the cannabinoid field and has several unique qualities including a 1) focus on the CNS, which is not present at any other Cannabinoid centered meeting, 2) strong emphasis on cutting-edge unpublished data, 3) continuing commitment to trainees through organization of the GRS, trainee mentoring program, and career development panels including “Women in Science” and “Publishing 101 Q&A,” for example. Discussions/debates focused on controversial topics will be new additions to this funding cycle.

项目摘要 CNS中的大麻素信号传导由大麻素受体CB 1和CB 2及其同源物组成 外源性和内源性配体。大麻素信号广泛分布在整个CNS中， 涉及多种重要的神经生物学过程，包括奖励信号传导， 成瘾，能量稳态调节，学习和记忆，运动功能，焦虑和社交 功能因此，了解大麻素信号传导的神经生物学可能具有广泛的意义 生理中枢神经系统功能和神经精神疾病的病理生理学。戈登研究 关于“大麻素在中枢神经系统中的功能”的会议（GRC）及其相关的戈登研究研讨会 (GRS)代表了中枢神经系统中大麻素功能领域的典型科学论坛。这 GRC会议因吸引该领域最活跃和最知名的科学家而享有盛誉， 这是旨在成为下一代大麻素的学员的“必须参加”会议， 神经科学家在此更新申请中，我们要求继续提供财政支持，以部分覆盖 博士前和博士后学员参加2019年和2021年“大麻”的费用 在CNS”GRS/GRC会议中发挥作用。本次会议的主要目的是：（1）提供 在戈登研究会议的传统和精神杰出的科学计划。这些 包括一位诺贝尔奖获得者在内的该领域领导人对尖端未发表数据的强调， 谁已经同意提出新的工作;一个社区的气氛，促进非正式讨论， 鼓励新的合作，并在全体会议上纳入发言人以外的领域，可以刺激 大麻素研究的新领域，以及2）促进青年科学家和受训人员在 领域这将主要通过GRS的组织来执行，重点是增加专业网络 青年科学家的培训，为学员提供口头科学介绍的场所， 发展研讨会。这次会议的第二个新办法是执行一项 在GRC期间建立指导系统，以增加学员和高级科学家之间的1：1互动， 领域“中枢神经系统中的大麻素功能”GRS/GRC被广泛认为是 大麻素领域，并有几个独特的品质，包括1）集中在中枢神经系统，这是不存在的 在任何其他以大麻为中心的会议上，2）强烈强调尖端未发表的数据，3） 通过组织GRS、学员指导计划和职业生涯， 例如，发展小组包括“科学界的妇女”和“出版101问答”。 重点讨论/辩论有争议的议题将是这一供资周期的新内容。