DELINEATING THE ROLE OF GENETIC INFLUENCES ON CANNABIS INVOLVEMENT

描述遗传影响对大麻参与的作用

• 批准号: 9891978
• 负责人: ARPANA AGRAWAL
• 金额: $ 11.91万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9891978
• 关键词: Amygdaloid structure; Area; Awareness; Behavior; Big Data; Bioinformatics; Biological; Biology; Brain; Cannabis; Child Abuse; Clinical; Collaborations; Communities; Data; Data Set; Developed Countries; Development; Disease; Dissection; Etiology; Funding; Genes; Genetic; Genetic Predisposition to Disease; Genetic Research; Genetic Risk; Genetic study; Genomics; Goals; Heritability; K-Series Research Career Programs; Knowledge; Legal; Link; Long-Term Effects; Marijuana Dependence; Mediating; Mental Health; Mental disorders; Mentors; Methodology; Methods; Modernization; National Institute of Drug Abuse; Neurobiology; Nicotine Dependence; Outcome; Pathway interactions; Peer Review; Perception; Phase; Phenotype; Policies; Politics; Positioning Attribute; Predisposition; Psychopathology; Public Health; Publications; Publishing; Reaction; Reporting; Research; Research Personnel; Research Project Grants; Research Training; Resources; Role; Sample Size; Sampling; Schizophrenia; Scientist; Secure; Series; Signal Transduction; Site; Source; Strategic Planning; Structure; Substance Use Disorder; Time; Training; Twin Multiple Birth; United States; Variant; Ventral Striatum; Work; Youth; addiction; brain volume; career development; childhood adversity; comorbidity; design; epigenome; experience; genetic approach; genetic architecture; genome wide association study; genome-wide; genomic data; imaging genetics; interest; marijuana use; marijuana use disorder; mid-career faculty; multidisciplinary; neurogenetics; neuroimaging; novel; polygenic risk score; psychiatric genomics; psychogenetics; psychosocial; responsible research conduct; trend

This competing renewal of an Independent Investigator Career Development Award (K02) aims to expand the candidate's research expertise in genetic studies of cannabis involvement in two main areas: (a) integration of neuroimaging with emerging genomic results for cannabis involvement; and (b) new methodology for genomic (meta) analyses, in particular, understanding how genomic factors influence the comorbidity between cannabis involvement and psychiatric as well as psychosocial correlates. She will also work closely with leaders in the field of big data psychiatric genetics to expand her expertise in managing consortia, developing novel collaborations, expanding her work in a clinical direction and in dissemination and community engagement. In addition, the candidate will continue to mentor trainees in addiction and genomic methods and maintain her training in responsible conduct of research. The overarching goal of this K02 is to provide the candidate, a tenured Associate Professor, with protected time to conduct research on parsing the role of genetic influences on cannabis involvement. The public health significance of this research is particularly timely as a wave of legislative change surrounding the status of recreational cannabis sweeps the nation and scientific interest in the deleterious correlates and consequences of cannabis use intensifies. The candidate's research portfolio is amongst the few that is primarily focused on genetically informed studies of cannabis involvement and continues to inform this research debate with empirical findings. With support from the first phase of funding, the candidate published numerous peer-reviewed studies, and generated findings documenting (a) new loci for cannabis use disorders (CUD), (b) the role of childhood abuse on genetic risk for CUD and (c) polygenic approaches to genetic dissection of variance in CUD. She has also renewed her existing R01 and secured funding for two additional R01s. Most recently, she co-established the Psychiatric Genomics Consortium's Substance Use Disorders (PGC-SUD) workgroup, a new addition to the PGC repertoire of highly powered genomewide association meta-analytic studies. The next phase of training and collaboration will extend the candidate's expertise in one existing (genomics) and one novel (neurogenetics) direction. First, via involvement in the PGC, the candidate will master the most recently developed genomic methods, including integrated approaches for bioinformatics and epigenome annotation. This will solidify her knowledge in modern genomic methods and allow her to develop the PGC-SUD group as the foremost source for high quality SUD genetics research. Second, the candidate will gain proficiency in neuroimaging and imaging genetics approaches to begin to integrate her genomic discoveries with neurobiological correlates. This will effectively position the candidate to propose cutting-edge imaging genetics research applications. Overall, continued funding will result in high-quality, peer-reviewed publications that will contribute to the public debate regarding the etiology, progression and consequences of the use of cannabis, a highly popular psychoactive substance.

独立调查员职业发展奖（K02）的竞争性更新旨在扩大 候选人在大麻遗传研究方面的研究专长涉及两个主要领域： 神经成像与大麻参与的新兴基因组结果;和（B）基因组成像的新方法学。 （meta）分析，特别是了解基因组因素如何影响大麻与 参与和精神以及心理社会相关因素。她还将与各国领导人密切合作， 大数据精神病学遗传学领域，以扩大她在管理财团，开发新的 合作，扩大她的工作在临床方向和传播和社区参与。在 此外，候选人将继续指导学员在成瘾和基因组方法，并保持她 培训负责任的研究行为。本K02的首要目标是为候选人提供 终身副教授，有保护的时间进行研究，分析遗传影响的作用 关于大麻的事这项研究的公共卫生意义是特别及时的，因为一波 围绕娱乐性大麻地位的立法变化席卷全国， 使用大麻的有害关联和后果加剧。候选人的研究组合是 在少数几个主要集中在大麻参与遗传信息研究， 继续以实证研究结果为这场研究辩论提供信息。在第一阶段资金的支持下， 候选人发表了许多同行评议的研究，并产生了记录（a） 大麻使用障碍（CUD），（B）儿童期滥用对CUD遗传风险的作用和（c）多基因 在CUD中的方差的遗传解剖的方法。她还更新了现有的R01， 为另外两个R01提供资金。最近，她共同建立了精神病基因组学联盟的 物质使用障碍（PGC-SUD）是一个新的PGC剧目的高功率 全基因组关联荟萃分析研究。下一阶段的培训和合作将扩大 候选人在一个现有（基因组学）和一个新（神经遗传学）方向的专业知识。第一，通过参与 在PGC中，候选人将掌握最新开发的基因组方法，包括整合 生物信息学和表观基因组注释的方法。这将巩固她在现代基因组学方面的知识， 方法，并允许她发展PGC-SUD组作为高质量SUD遗传学的首要来源 research.其次，候选人将获得神经影像学和成像遗传学方法的熟练程度， 开始将她的基因组发现与神经生物学关联相结合。这将有效地定位 候选人提出尖端的成像遗传学研究应用。总体而言，持续的资金将 产生高质量的同行评议出版物，这将有助于关于病因的公众辩论， 大麻是一种非常流行的精神活性物质，使用大麻的进展和后果。