Lipid Signaling in Chemotaxis

趋化作用中的脂质信号传导

• 批准号: 9898604
• 负责人: Miho Iijima
• 金额: $ 14.76万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9898604
• 关键词: Arthritis; Asthma; Atherosclerosis; Behavior; Binding; Biochemistry; Cell membrane; Cells; Cellular biology; Chemicals; Chemotaxis; Cytoskeletal Modeling; Disease; Funding; Funding Opportunities; Genetic; Goals; Link; Lipids; Malignant Neoplasms; Molecular; Myosin Type I; PTEN gene; Pathogenesis; Research Project Grants; Signal Transduction; extracellular; human disease; migration; parent grant; recruit

Summary Through the funding opportunity described in PAR-18-591, this proposal seeks funds to purchase a Amersham Typhoon FLA Phosphoimager. The goals of the propose study are to investigate how cells sense extracellular chemical gradients and control their migration behaviors. The Specific Aims of the parent grant focus on the mechanisms that stabilize directional sensing, link PIP3-binding myosin I to cytoskeletal reorganization and recruit PTEN to the plasma membrane.

总结 通过PAR-18-591中描述的融资机会，本提案寻求资金购买阿默舍姆 台风弗拉磷光成像仪。这项研究的目的是研究细胞如何感知细胞外 化学梯度和控制它们的迁移行为。家长补助金的具体目标侧重于 稳定定向传感的机制，将PIP 3结合肌球蛋白I与细胞骨架重组联系起来， 将PTEN募集到质膜上。

项目成果

Analysis of chemotaxis in Dictyostelium.

• DOI: 10.1007/978-1-61779-166-6_26
• 发表时间: 2012
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Cai, Huaqing;Huang, Chuan-Hsiang;Devreotes, Peter N;Iijima, Miho
• 通讯作者: Iijima, Miho

Making a Division Apparatus on Mitochondria.

在线粒体上制作分裂装置。

• DOI: 10.1016/j.tibs.2016.02.001
• 发表时间: 2016
• 期刊: Trends in biochemical sciences
• 影响因子: 13.8
• 作者: Yamada,Tatsuya;Adachi,Yoshihiro;Iijima,Miho;Sesaki,Hiromi
• 通讯作者: Sesaki,Hiromi

Extracellular vesicles direct migration by synthesizing and releasing chemotactic signals.

• DOI: 10.1083/jcb.201710170
• 发表时间: 2018-08-06
• 期刊: The Journal of cell biology
• 作者: Kriebel PW;Majumdar R;Jenkins LM;Senoo H;Wang W;Ammu S;Chen S;Narayan K;Iijima M;Parent CA
• 通讯作者: Parent CA

A GPCR Handles Bacterial Sensing in Chemotaxis and Phagocytosis.

GPCR 处理趋化和吞噬作用中的细菌感应。

• DOI: 10.1016/j.devcel.2016.02.006
• 发表时间: 2016
• 期刊: Developmental cell
• 影响因子: 11.8
• 作者: Senoo,Hiroshi;Sesaki,Hiromi;Iijima,Miho
• 通讯作者: Iijima,Miho

TGF-β induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma.

TGF-β 诱导磷酸酶和张力蛋白同源物的磷酸化：对青光眼小梁网组织纤维化的影响。

• DOI: 10.1038/s41598-017-00845-x
• 发表时间: 2017
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Tellios,Nikoleta;Belrose,JillianC;Tokarewicz,AlexanderC;Hutnik,Cindy;Liu,Hong;Leask,Andrew;Motolko,Michael;Iijima,Miho;Parapuram,SunilK
• 通讯作者: Parapuram,SunilK