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An Ultra High-Density Virtual Array with Nonlinear Processing of Multimodal Neural Recordings

具有多模态神经记录非线性处理的超高密度虚拟阵列

基本信息

批准号：
9766300
负责人：
Duygu Kuzum
金额：
$ 22.89万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2020-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9766300
关键词：
3-Dimensional Affect Algorithms Area Behavior Brain Calcium Calcium Signaling Caliber Cells Chemicals Collaborations Data Data Collection Data Set Deposition Development Dimensions Disease Dystonia Electrical Engineering Electrocorticogram Electrodes Electrophysiology (science)Epilepsy Exploratory/Developmental Grant Functional disorder Geometry Goals Image Individual Lead Learning Measurement Mental Depression Methods Modality Modeling Multimodal Imaging Nervous system structure Neurons Neurosciences Noise Optics Outcome Parkinson Disease Population Research Resolution Scanning Schizophrenia Signal Transduction Surface Synaptic Potentials System Techniques Technology Testing base computer framework computerized data processing density design electric impedance experience experimental study graphene high resolution imaging holistic approach in vivo innovation multimodal data multimodality nanoparticle nervous system disorder network dysfunction neural circuit novel strategies operation optical imaging optogenetics relating to nervous system sensor signal processing spatial integration temporal measurement two-photon virtual

项目摘要

An Ultra High-Density Virtual Array with Nonlinear Processing of Multimodal Neural Recordings A major goal of neuroscience is to record the activity of all neurons in an area of an intact brain and understand the relationship between neural activity and behavior. However, with current technologies, it is not feasible to have a direct and simultaneous access to every neuron in a three-dimensional brain area. Here we propose a novel approach, combining an innovative signal processing method with optical and electrical recording technologies to `virtually' record from all neurons in a three dimensional volume. If successful, this approach will allow us to substantially increase the number of recorded neurons without the need for direct optical or electrical access to each neuron. The proposed Virtual Array technology has the potential to dramatically increase the number of simultaneously recorded neurons in an intact brain relatively non- invasively. The common approaches include high-density electrophysiological probes, which are highly invasive and also limited in the density of recording, and fast-scanning optical techniques that have limited temporal resolution. As an alternative approach, we propose to develop a framework to computationally increase the number of recorded neurons out of recording data from simultaneous electrophysiology and imaging. The computational framework will be developed from a dataset in which micro- electrocorticogram (µECoG) are recorded simultaneously while the activities of the underlying neurons is recorded with two-photon calcium imaging at multiple cortical depths. We will virtually reconstruct this single-cell activity by solving appropriate optimization problem involving forward models for µECoG recordings and calcium signals. This optimization problem will be solved using alternating convex algorithms.

一种多模态非线性处理的超高密度虚拟阵列