Internalizing Behaviors and Neuroimaging Outcomes: Impact of PBDE and PFC Exposures

项目概要/摘要 人类暴露于环境污染物是普遍存在的，并且人们越来越关注暴露于环境污染物。 有些可能与儿童神经行为问题的增加有关。鉴于缺乏确凿的证据 许多环境毒物的证据，有一个精心设计的纵向研究的迫切需要， 产前和产后接触，并进行长期随访，以解决有关 这些化学物质，特别是对神经行为终点的影响。我们将学习两门化学课， 所有美国人都暴露在多溴联苯醚（PBDEs）和全氟化学品中， （PFCs），它们分别被用作阻燃剂和表面活性剂。在一个既定的队列中， 在健康结果和环境措施中， （首页）研究，我们将确定产前和儿童暴露于这些持续的 污染物和内化行为，包括焦虑，抑郁和社会障碍。我们还将获得 神经影像学结果，以检查与暴露的关联。HOME研究在1999年期间招募了妇女， 生下的孩子，一直到8岁。我们将延长随访时间，包括研究访视， 11- 12岁，研究青春期前的协会。产前暴露量采用母亲 妊娠和新生儿样本，目前正在分析多个儿童样本。超过97%的 参与的妇女在怀孕期间可检测到多溴二苯醚和全氟化学品的水平;与全国水平相当 报告水平。我们假设暴露于这些化学物质会微妙地改变大脑， 神经行为缺陷，将是明显的增加内化症状和不利的变化， 解剖结构、神经化学、白色物质束的组织和神经网络的连接。 目标1：确定产前和儿童期接触多溴联苯醚和全氟化碳对体内 在11-12岁儿童的纵向出生队列中的症状。 目标2：确定产前和儿童期接触多溴二苯醚对大脑结构的影响， 组织和功能在11-12岁儿童的纵向出生队列中。 探索性目的（EA）：确定产前和儿童期暴露于PFCs对大脑的影响 结构，组织和功能在11-12岁儿童的纵向出生队列中。 目的3：确定脑结构、组织和功能在脑缺血中的潜在中介影响。 产前和儿童期接触多溴联苯醚与内在症状之间的纵向关系 11-12岁儿童的出生队列。 目标4：确定适当的统计方法，以确定单一和多个 多溴二苯醚和全氟化碳暴露与多个发育阶段的神经发育。

Project Summary/Abstract Human exposure to environmental contaminants is ubiquitous, and there is growing concern that exposure to some may be linked with the rise in neurobehavioral problems in children. Given the lack of conclusive evidence for many environmental toxicants, there is a critical need for well-designed longitudinal studies of prenatal and postnatal exposure with long-term follow-up to address focused questions about the impact of these chemicals, especially on neurobehavioral endpoints. We will study two chemical classes to which nearly all of the US population are exposed, polybrominated diphenyl ethers (PBDEs) and perfluorinated chemicals (PFCs), that have been used as flame retardants and surfactants, respectively. Among an established cohort of typically developing pre-adolescent children within the Health Outcomes and Measures of the Environment (HOME) Study, we will determine associations between prenatal and childhood exposure to these persistent pollutants and internalizing behaviors including anxiety, depression and social impairment. We will also obtain neuroimaging outcomes to examine associations with exposure. The HOME Study enrolled women during pregnancy and has thus far followed offspring until age 8y. We will extend follow-up to include a study visit at 11-12y to study associations in the pre-adolescent period. Prenatal exposures were measured using maternal pregnancy and newborn specimens with multiple childhood samples currently being analyzed. Over 97% of participating women had detectable levels of PBDEs and PFCs during pregnancy; comparable with nationally reported levels. We hypothesize that exposures to these chemicals subtly alter the brain to produce neurobehavioral deficits that will be evident in increased internalizing symptoms and adverse changes in anatomical structure, neurochemistry, organization of white matter tracts, and connectivity of neural networks. Aim 1: To determine the impact of prenatal and childhood exposures to PBDEs and PFCs on internalizing symptoms in a longitudinal birth cohort of 11-12 year old children. Aim 2: To determine the impact of prenatal and childhood exposures to PBDEs on brain structure, organization, and function in a longitudinal birth cohort of 11-12 year old children. Exploratory aim (EA): To determine the impact of prenatal and childhood exposures to PFCs on brain structure, organization, and function in a longitudinal birth cohort of 11-12 year old children. Aim 3: To determine the potential mediational impact of brain structure, organization and function in the relationship between prenatal and childhood exposures to PBDEs and internalizing symptoms in a longitudinal birth cohort of 11-12 year old children. Aim 4: To identify appropriate statistical methodologies to determine the association of single and multiple PBDE and PFC exposures with neurodevelopment across multiple developmental stages.