Longitudinal Impact of Air Pollution on Mental Health and Neuroimaging Outcomes during Adolescence in the Cincinnati Combined Childhood Cohorts (C4)

空气污染对辛辛那提联合儿童队列 (C4) 青春期心理健康和神经影像结果的纵向影响

• 批准号: 10543450
• 负责人: Kim M Cecil
• 金额: $ 108.49万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-03 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10543450
• 关键词: 12 year old; 18 year old; Acute; Address; Adolescence; Adolescent; Adult; Affect; Age; Air Pollutants; Air Pollution; American; Aminobutyric Acids; Anatomy; Anxiety; Attention deficit hyperactivity disorder; Biological; Birth; Brain; Cause of Death; Child; Childhood; Conceptions; Data; Development; Diameter; Diesel Exhaust; Disease; Early identification; Early treatment; Emergency department visit; Environment; Exposure to; Functional Magnetic Resonance Imaging; Future; Genetic; Genetic Predisposition to Disease; Glutathione; Health; Hormonal; Hypersensitivity; Incidence; Intervention; Justice; Life; Link; Longitudinal cohort; Measures; Mediating; Mental Depression; Mental Health; Mental disorders; Metabolism; Modeling; Motor Skills; Neuropsychology; Ohio; Outcome; Oxidative Stress Induction; Particulate Matter; Pathway interactions; Policies; Population; Prevalence; Prevention; Preventive; Primary Prevention; Prospective cohort; Recurrence; Research; Risk; Risk Factors; Role; School Drop-Outs; Schools; Structure; Student Dropouts; Suicide attempt; System; Teenagers; Testing; Time; Toxicology; Unemployment; Well in self; age group; autism spectrum disorder; brain volume; child depression; cognitive ability; cohort; critical period; diagnostic criteria; disorder risk; early adolescence; epidemiology study; experience; externalizing behavior; fine particles; follow-up; gamma-Aminobutyric Acid; hospitalization rates; meter; modifiable risk; neuroimaging; neuroinflammation; neurotoxic; novel; pollutant; prenatal; prevent; prospective; public health intervention; screening; social; social determinants; study population; substance use; suicidal risk; traffic-related air pollution; ultrafine particle; young adult

PROJECT SUMMARY / ABSTRACT More than one in five adolescents will experience a mental health disorder, including depression and anxiety, and the prevalence of these conditions is increasing. Among adolescents, depression and anxiety are linked to increased risk of suicide, a leading cause of death in this age group. Identifying underlying and modifiable contributors to these conditions is crucial as current research and interventions focus on screening and treatment rather than prevention. Here, we posit that air pollution, in addition to genetic susceptibility, social determinants, familial and school issues, and other factors, is a contributor to mental health disorders. Toxicological studies demonstrate that fine particulate matter (PM2.5) and traffic-related air pollution (TRAP) are neurotoxic, and epidemiologic studies consistently link these pollutants to reduced cognitive abilities and increased externalizing behaviors. However, few studies have prospectively evaluated the role of air pollution exposure on mental health disorders in childhood. Recently, we found that childhood air pollution exposure is associated with increased risk for depression and anxiety at age 12 years. However, the role of air pollution in the onset and persistence of mental health disorders during adolescence, and changes in brain structure, organization, and function linked to these outcomes, remain poorly understood. Therefore, we hypothesize that exposure to air pollution during critical periods of brain development, including adolescence, is associated with adverse mental health outcomes. We will leverage existing longitudinal data from the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS) and the Health Outcomes and Measures of the Environment (HOME) Study, two prospective cohorts located in Cincinnati, Ohio, to address this hypothesis. Both cohorts have been followed from birth and evaluated with concordant measures of mental health and neuroimaging at age 12 years. We will conduct new follow-up at age 18 years to assess the onset and persistence of mental health outcomes through adolescence and apply validated models for PM2.5 and TRAP to characterize air pollution exposure from conception through age 18 years. We will also acquire novel neuroimaging outcomes, including brain -aminobutyric acid and glutathione concentrations accompanied by anatomical and functional magnetic resonance imaging. Our aims are to: 1) determine the association between exposure to PM2.5 and TRAP during distinct developmental periods and the onset and persistence of mental health outcomes in adolescence; 2) determine the association between exposure to PM2.5 and TRAP during distinct developmental periods and neuroimaging outcomes in late adolescence; and 3) determine whether changes in brain volume, organization, metabolism, and function mediate associations between PM2.5 and TRAP exposure and mental health outcomes. Examining air pollution as a novel and modifiable risk factor will provide critical data to guide primary prevention aimed at reducing the burden of mental health disorders in adolescence.

项目概要/摘要 超过五分之一的青少年会经历心理健康障碍，包括抑郁和焦虑， 而且这些病症的患病率正在增加。在青少年中，抑郁和焦虑与 自杀风险增加，自杀是该年龄段的主要原因。识别底层和可修改的 由于当前的研究和干预措施侧重于筛查和干预，因此导致这些情况的因素至关重要。 治疗而非预防。在这里，我们假设空气污染除了遗传易感性之外，还与社会因素有关。 决定因素、家庭和学校问题以及其他因素是导致心理健康障碍的因素。 毒理学研究表明细颗粒物 (PM2.5) 和交通相关空气污染 (TRAP) 神经毒性和流行病学研究一致将这些污染物与认知能力下降和 外化行为增加。然而，很少有研究前瞻性地评估空气污染的作用 童年时期接触精神健康障碍。最近，我们发现儿童时期空气污染暴露 与 12 岁时抑郁和焦虑的风险增加有关。然而，空气污染在 青春期心理健康障碍的发生和持续，以及大脑结构的变化， 与这些结果相关的组织和功能仍然知之甚少。因此，我们假设 在大脑发育的关键时期（包括青春期）接触空气污染与 不良的心理健康结果。我们将利用辛辛那提童年的现有纵向数据 过敏和空气污染研究 (CCAAPS) 以及环境的健康结果和措施 (HOME) 位于俄亥俄州辛辛那提的两个前瞻性队列研究旨在解决这一假设。两个队列 从出生起就进行跟踪，并使用心理健康和神经影像学的一致措施进行评估 年龄 12 岁。我们将在 18 岁时进行新的随访，以评估精神障碍的发生和持续情况。 整个青春期的健康结果，并应用经过验证的 PM2.5 和 TRAP 模型来表征空气 从受孕到 18 岁期间接触污染。我们还将获得新颖的神经影像结果， 包括大脑 γ-氨基丁酸和谷胱甘肽浓度以及解剖学和功能性 磁共振成像。我们的目标是：1) 确定 PM2.5 暴露与 不同发育时期的 TRAP 以及心理健康结果的发生和持续 青春期; 2) 确定不同发育期间暴露于 PM2.5 和 TRAP 之间的关联 青春期后期的经期和神经影像学结果； 3）确定脑容量是否发生变化， 组织、代谢和功能介导 PM2.5 和 TRAP 暴露与心理之间的关联 健康结果。将空气污染视为一种新颖且可改变的风险因素，将为指导提供关键数据 初级预防旨在减轻青春期精神健康障碍的负担。