Longitudinal Impact of Air Pollution on Mental Health and Neuroimaging Outcomes during Adolescence in the Cincinnati Combined Childhood Cohorts (C4)

空气污染对辛辛那提联合儿童队列 (C4) 青春期心理健康和神经影像结果的纵向影响

• 批准号: 10543450
• 负责人: Kim M Cecil
• 金额: $ 108.49万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-03 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10543450
• 关键词: 12 year old; 18 year old; Acute; Address; Adolescence; Adolescent; Adult; Affect; Age; Air Pollutants; Air Pollution; American; Aminobutyric Acids; Anatomy; Anxiety; Attention deficit hyperactivity disorder; Biological; Birth; Brain; Cause of Death; Child; Childhood; Conceptions; Data; Development; Diameter; Diesel Exhaust; Disease; Early identification; Early treatment; Emergency department visit; Environment; Exposure to; Functional Magnetic Resonance Imaging; Future; Genetic; Genetic Predisposition to Disease; Glutathione; Health; Hormonal; Hypersensitivity; Incidence; Intervention; Justice; Life; Link; Longitudinal cohort; Measures; Mediating; Mental Depression; Mental Health; Mental disorders; Metabolism; Modeling; Motor Skills; Neuropsychology; Ohio; Outcome; Oxidative Stress Induction; Particulate Matter; Pathway interactions; Policies; Population; Prevalence; Prevention; Preventive; Primary Prevention; Prospective cohort; Recurrence; Research; Risk; Risk Factors; Role; School Drop-Outs; Schools; Structure; Student Dropouts; Suicide attempt; System; Teenagers; Testing; Time; Toxicology; Unemployment; Well in self; age group; autism spectrum disorder; brain volume; child depression; cognitive ability; cohort; critical period; diagnostic criteria; disorder risk; early adolescence; epidemiology study; experience; externalizing behavior; fine particles; follow-up; gamma-Aminobutyric Acid; hospitalization rates; meter; modifiable risk; neuroimaging; neuroinflammation; neurotoxic; novel; pollutant; prenatal; prevent; prospective; public health intervention; screening; social; social determinants; study population; substance use; suicidal risk; traffic-related air pollution; ultrafine particle; young adult

PROJECT SUMMARY / ABSTRACT More than one in five adolescents will experience a mental health disorder, including depression and anxiety, and the prevalence of these conditions is increasing. Among adolescents, depression and anxiety are linked to increased risk of suicide, a leading cause of death in this age group. Identifying underlying and modifiable contributors to these conditions is crucial as current research and interventions focus on screening and treatment rather than prevention. Here, we posit that air pollution, in addition to genetic susceptibility, social determinants, familial and school issues, and other factors, is a contributor to mental health disorders. Toxicological studies demonstrate that fine particulate matter (PM2.5) and traffic-related air pollution (TRAP) are neurotoxic, and epidemiologic studies consistently link these pollutants to reduced cognitive abilities and increased externalizing behaviors. However, few studies have prospectively evaluated the role of air pollution exposure on mental health disorders in childhood. Recently, we found that childhood air pollution exposure is associated with increased risk for depression and anxiety at age 12 years. However, the role of air pollution in the onset and persistence of mental health disorders during adolescence, and changes in brain structure, organization, and function linked to these outcomes, remain poorly understood. Therefore, we hypothesize that exposure to air pollution during critical periods of brain development, including adolescence, is associated with adverse mental health outcomes. We will leverage existing longitudinal data from the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS) and the Health Outcomes and Measures of the Environment (HOME) Study, two prospective cohorts located in Cincinnati, Ohio, to address this hypothesis. Both cohorts have been followed from birth and evaluated with concordant measures of mental health and neuroimaging at age 12 years. We will conduct new follow-up at age 18 years to assess the onset and persistence of mental health outcomes through adolescence and apply validated models for PM2.5 and TRAP to characterize air pollution exposure from conception through age 18 years. We will also acquire novel neuroimaging outcomes, including brain -aminobutyric acid and glutathione concentrations accompanied by anatomical and functional magnetic resonance imaging. Our aims are to: 1) determine the association between exposure to PM2.5 and TRAP during distinct developmental periods and the onset and persistence of mental health outcomes in adolescence; 2) determine the association between exposure to PM2.5 and TRAP during distinct developmental periods and neuroimaging outcomes in late adolescence; and 3) determine whether changes in brain volume, organization, metabolism, and function mediate associations between PM2.5 and TRAP exposure and mental health outcomes. Examining air pollution as a novel and modifiable risk factor will provide critical data to guide primary prevention aimed at reducing the burden of mental health disorders in adolescence.

项目摘要/摘要