Antimicrobial resistance in enteric bacteria from retail meat in Iowa: A NARMS Retail Food Surveillance Project

项目总结/摘要 1爱荷华州零售肉类中肠道细菌的耐药性：一个NARMS零售 2食物监察计划 3抗菌素耐药性（AMR）是影响人类福祉的主要健康威胁， 4动物和世界各地的环境。强大而全面的监控系统 5强调“同一健康”的方法是有效对抗抗生素耐药性的必要条件。在 6美国，国家抗菌素耐药性监测系统的零售部门 7（NARMS）隶属于美国食品药品监督管理局，兽医中心（FDA- 8 CVM）在选定的肠道细菌（非伤寒沙门氏菌， 9弯曲杆菌，肠球菌和大肠杆菌）从零售生肉（鸡肉，地面 10火鸡和牛肉，和猪排）在14个州。NARMS计划做出了重大贡献 监测食物链中AMR的来源和趋势。加强努力， 12打击AMR，FDA最近建立了一个合作协议计划，以扩大 13 NARMS监视网络遍布美国。在本申请中，我们建议建立一个 14与国家农业资源管理局合作，成为爱荷华州AMR监测的网络实验室。 15由于爱荷华州目前没有参与NARMS监测计划，因此将其列为 16个新网站将大大增加和加强 17个国家零售食品监测计划。我们将获取并处理生肉样本 18（鸡肉，猪排，碎牛肉，和碎火鸡）从杂货店在爱荷华州和文化 分离沙门氏菌、弯曲杆菌、E.大肠杆菌和肠球菌，并提供 每月向FDA提供20个分离株用于监测。我们的合作将有助于 21 NARMs实现了所述零售食品监督计划的目的和目标 22在FOA PAR-16 - 099 "NARMS合作协议方案，以提高和加强 23零售食物样本的抗生素耐药性监测（U01）。这项合作工作 24将大大有助于缓解食物链中的AMR，从而改善食物质量。 25安全与健康 26 27 28

Project Summary/Abstract 1 Antimicrobial resistance in enteric bacteria from retail meat in Iowa: A NARMS Retail 2 Food Surveillance Project 3 Antimicrobial resistance (AMR) is a major health threat affecting the well-being of humans, 4 animals, and the environment worldwide. Robust and comprehensive surveillance systems 5 emphasizing the “One Health” approach are necessary for effectively combatting AMR. In the 6 United States, the retail arm of the National Antimicrobial Resistance Monitoring System 7 (NARMS) under the Food and Drug Administration, Center for Veterinary Medicine (FDA- 8 CVM ) performs surveillance of AMR in select enteric bacteria (non-typhoidal Salmonella, 9 Campylobacter, Enterococcus and Escherichia coli) from retail raw meat (chicken, ground 10 turkey and beef, and pork chop) in 14 states. The NARMS program has contributed significantly 11 to monitoring the sources and trends of AMR in the food chain. To enhance the effort on 12 combating AMR, FDA has recently established a cooperative agreement program to expand the 13 NARMS surveillance network throughout the U.S. In this application, we propose to establish a 14 partnership with the NARMS and become a network laboratory for AMR surveillance in Iowa. 15 Since Iowa does not currently participate in the NARMS surveillance program, its inclusion as a 16 new site would substantially increase and strengthen the capacity and effectiveness of the 17 national surveillance program in retail food. We will obtain and process raw meat samples 18 (chicken, pork chop, ground beef, and ground turkey) from grocery stores in Iowa and culture 19 them for isolation of Salmonella, Campylobacter, E. coli and Enterococcus, and provide the 20 isolates to the FDA for surveillance purpose on a monthly basis. Our partnership will help the 21 NARMs achieve the objectives and goals of the Retail Food Surveillance Program as described 22 in the FOA PAR-16-099 “NARMS Cooperative Agreement Program to Enhance and Strengthen 23 Antibiotic Resistance Surveillance in Retail Food Specimens (U01)”. This collaborative work 24 will significantly contribute to mitigation of AMR in the food chain and thus will improve food 25 safety and public health. 26 27 28