Arizona Department of Health Services FERN Chemistry Project

亚利桑那州卫生服务部 FERN 化学项目

• 批准号: 9767554
• 负责人: Jason Foster Mihalic
• 金额: $ 33.6万
• 依托单位: ARIZONA STATE DEPARTMENT OF HLTH SRVCS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9767554
• 关键词: Arizona; Department; Health; Services; FERN

AZDHS FERN Chemistry Project Project Summary The Arizona FERN Chemistry Program will utilize the GC/MS, LC/MS/MS, ICP- MS, ELISA, and IC-MS instrument platforms to continue with research projects started in the previous five-year grant cycle. Specifically inorganic work in a Level 3 multi-lab validation of EAM 4.7 Inductively Coupled Plasma – Mass Spectrometric (ICP-MS) and matrix expansion of the arsenic speciation methods EAM 4.10 and EAM 4.11. Ongoing organic projects include a Level 3 multi-lab validation of the T-022 version 9 Poison Screen using HPLC-MS, an instrument extension to CHE.0006.01 for using an Agilent 5977 GC/MS systems, and adding an amendment to CHE.0006.01 for use of hydrogen as a carrier gas instead of helium. In addition, the program proposes original research projects that will enhance the food safety and food defense capability and capacity of FERN. Specifically an instrument and analyte expansion of the T-034 Screen for Fluoroacetate, Azide, and Nitrite using Ion Chromatography Mass Spectrometry (IC-MS), the development of a GC-MS pesticide and endocrine disruptor screen utilizing deconvolution reporting software, the development of a qualitative high throughput screen for toxic metals with handheld X- Ray Fluorescence analyzers, the development of a high throughput method to screen for illegal food dyes, and the development of a method for speciation of chromium in food matrices. The program remains available to assist the FDA with surge capacity needs and will continue towards ISO-17025 accreditation.

AZDHS蕨类化学项目 项目摘要 亚利桑那州蕨类化学项目将利用GC/MS、LC/MS/MS、ICP- MS、ELISA和IC-MS仪器平台将继续进行研究项目 开始于上一个五年期赠款周期。具体地说，无机物在一定程度上 3EAM 4.7电感耦合等离子体质谱仪的多实验室验证 砷形态分析方法的光谱分析(电感耦合等离子体质谱)和基质展开法 EAM 4.10和eAM 4.11。正在进行的有机项目包括一个3级多实验室 使用高效液相色谱-质谱仪验证T-022版本9毒物筛查结果 使用安捷伦5977 GC/MS系统的CHE.0006.01的扩展，并增加了 对CHE.0006.01使用氢气作为载气而不是 氦。 此外，该计划提出了原创性的研究项目，将增强 蕨类植物的食品安全和食品防御能力。具体而言，是 T-034筛分氟乙酸酯、叠氮、 和亚硝酸盐的离子色谱质谱(IC-MS)， 气质联用农药及内分泌干扰物筛选技术的研究进展 反卷积报告软件，开发了质的高通量 用手持式X射线荧光分析仪筛查有毒金属 开发一种高通量的方法来筛选非法食用染料，以及 食品基质中铬形态分析方法的发展。 该计划仍可用于帮助FDA满足浪涌能力需求和 将继续朝着国际标准化组织-17025认证迈进。