Arizona Department of Health Services FERN Chemistry Project

亚利桑那州卫生服务部 FERN 化学项目

• 批准号: 9134624
• 负责人: Jason Foster Mihalic
• 金额: $ 37.8万
• 依托单位: ARIZONA STATE DEPARTMENT OF HLTH SRVCS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9134624
• 关键词: Arizona; Department; Health; Services; FERN

AZDHS FERN Chemistry Project Project Summary The Arizona FERN Chemistry Program will utilize the GC/MS, LC/MS/MS, ICP- MS, ELISA, and IC-MS instrument platforms to continue with research projects started in the previous five-year grant cycle. Specifically inorganic work in a Level 3 multi-lab validation of EAM 4.7 Inductively Coupled Plasma – Mass Spectrometric (ICP-MS) and matrix expansion of the arsenic speciation methods EAM 4.10 and EAM 4.11. Ongoing organic projects include a Level 3 multi-lab validation of the T-022 version 9 Poison Screen using HPLC-MS, an instrument extension to CHE.0006.01 for using an Agilent 5977 GC/MS systems, and adding an amendment to CHE.0006.01 for use of hydrogen as a carrier gas instead of helium. In addition, the program proposes original research projects that will enhance the food safety and food defense capability and capacity of FERN. Specifically an instrument and analyte expansion of the T-034 Screen for Fluoroacetate, Azide, and Nitrite using Ion Chromatography Mass Spectrometry (IC-MS), the development of a GC-MS pesticide and endocrine disruptor screen utilizing deconvolution reporting software, the development of a qualitative high throughput screen for toxic metals with handheld X- Ray Fluorescence analyzers, the development of a high throughput method to screen for illegal food dyes, and the development of a method for speciation of chromium in food matrices. The program remains available to assist the FDA with surge capacity needs and will continue towards ISO-17025 accreditation.

AZDHS Fern化学项目 项目摘要 亚利桑那州蕨类植物化学计划将利用GC/MS，LC/MS/MS，ICP- MS、ELISA和IC-MS仪器平台继续开展研究项目 从上一个五年赠款周期开始。特别是无机物在一个水平 3 EAM 4.7电感耦合等离子体-质谱的多实验室验证 光谱法（ICP-MS）和基质扩展砷形态分析方法 EAM 4.10和EAM 4.11。正在进行的有机项目包括一个3级多实验室 使用HPLC-MS（一种仪器）验证T-022版本9毒物筛查 CHE.0006.01的扩展，用于使用Agilent 5977 GC/MS系统，并添加 修改CHE.0006.01，使用氢气作为载气，而不是 氦气 此外，该计划提出了原创性的研究项目，将提高 食品安全和食品防御能力和FERN的能力。具体地 仪器和T-034筛查的分析物扩展，用于氟乙酸盐、叠氮化物 和亚硝酸盐的离子色谱质谱法（IC-MS）， 利用气相色谱-质谱联用技术筛选农药和内分泌干扰物 反卷积报告软件，开发了一个高通量的定性 用手持式X射线荧光分析仪筛选有毒金属， 开发一种高通量的方法来筛选非法食品染料， 食品基质中铬形态分析方法的开发。 该计划仍然可以帮助FDA满足激增的能力需求， 将继续获得ISO-17025认证。