Bioinformatics Core

项目总结 生物信息学核心的总体目标是使用先进的生物信息学工具来识别和改进 对流感感染和疫苗接种中先天免疫和获得性免疫反应的认识和比较 患有其他疾病。生物信息学核心将利用现有的信息学平台，并将它们调整为 是实现这些目标所必需的。生物信息学核心的目标是(1)提供强大的生物信息学 分析项目1、2和3生成的数据的方法，以及(2)分析来自公共存储库的数据 包括NIAID资助的IMMPORT和NCBI的基因表达总括作为假设项目 测试。 生物信息学核心将直接与所有项目合作，以满足它们对强大的生物信息学的需求 技巧。生物信息学核心将把所有项目产生的免疫图谱数据与那些 可从公共存储库获得，以实现多队列集成分析。生物信息学核心将发挥作用 为此与人类免疫监测中心(HIMC)密切合作。这将使参与的项目 最大限度地利用基因组、免疫监测和临床表型数据集来确定功能 测量元素之间的相关性，并指导这些推定元素的进一步生物学验证 依赖关系。

PROJECT SUMMARY The overall goal of the Bioinformatics Core is to use advanced bioinformatics tools for identification and improved understanding of the innate and adaptive immune response in influenza infection and vaccination and compare with other diseases. The Bioinformatics Core will utilize existing informatics platforms, and adapt them as needed, to achieve these goals. The goals of the Bioinformatics Core will (1) provide robust bioinformatics methods to analyze the data generated by Projects 1, 2 and 3, and (2) analyze data from public repositories including the NIAID-funded ImmPort and the NCBI Gene Expression Omnibus for the Projects for hypothesis testing. The Bioinformatics Core will directly work with all Projects to address their need for robust bioinformatics techniques. The Bioinformatics Core will integrate the immune profiling data generated by all Projects with those available from public repositories, to enable multi-cohort integrated analysis. The Bioinformatics Core will work closely with the Human Immune Monitoring Center (HIMC) for this purpose. This will enable participating Projects to maximally utilize the genomic, immune monitoring and clinical phenotypic data sets to determine functional dependencies among the measured elements and to direct further biological validation of these putative dependencies.