Human Imaging Shared Facility

人体成像共享设施

• 批准号: 9895650
• 负责人: Andrew Dennis Smith
• 金额: $ 21.85万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9895650
• 关键词: Biological Markers; Budgets; Cancer Center; Cancer Patient; Clinical Cancer Center; Clinical Research; Clinical Trials; Clinical/Radiologic; Collaborations; Comprehensive Cancer Center; Data; Data Analyses; Data Security; Databases; Development; Diffusion Magnetic Resonance Imaging; Elements; Ensure; Environment; Evaluation; Faculty; Goals; Grant; Guidelines; Health Information System; Human; Image; Image Analysis; Image Enhancement; Imaging Techniques; Investigation; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Measurement; Medical; Methods; NCI Center for Cancer Research; Nursing Research; Phase; Physiological; Positron-Emission Tomography; Preparation; Protocols documentation; Questionnaires; Radiology Specialty; Reader; Regulation; Reporting; Research; Research Activity; Research Personnel; Route; Scanning; Schedule; Secure; Services; Site; Specific qualifier value; Standardization; Techniques; Therapeutic Trials; Time; Translational Research; Translations; Ultrasonography; University of Alabama at Birmingham Cancer Center; Visit; Work; adjudication; anticancer research; biomarker development; cancer clinical trial; cancer imaging; clinical imaging; clinical practice; computerized data processing; data exchange; feasibility trial; human imaging; imaging biomarker; imaging modality; imaging study; member; novel; pre-clinical; preclinical imaging; programs; protocol development; quantitative imaging; radiologist; research study; response; serial imaging; software systems; tool; tumor

IMAGING GROUP HUMAN IMAGING SHARED FACILITY (HISF) ABSTRACT The Human Imaging Shared Facility (HISF) enhances imaging-related research activities included in the UAB- CCC's collaborative group portfolio and other clinical trials through the provision of a standardized approach for reviews of each UAB-CCC protocol and coordination of non-routine imaging services. The protocol review is performed by two research imaging coordinators who provide quotes for routine and nonroutine research imaging services in compliance with institutional and national regulations. Other HISF services include image data transfers and protocol specific imaging techniques, phantom scan/site qualification imaging, physicist, radiologist, or radiology technologist time, and procurement of information for image data forms. Image data transfers meet all UAB Health System Information Security (HSIS) requirements and are audited periodically by the UAB HSIS. Accurate and timely analysis of conventional imaging studies used for response assessment in cancer clinical trials makes up the bulk of services provided to members of the UAB-CCC. With dedicated subspecialty faculty radiologist interpretations coordinated by the assistance of the two radiology research imaging coordinators and a metrics coordinator, protocol-specific metrics are generated by the same set of designated readers throughout the course of each therapeutic trial for consistent longitudinal metrics reporting. In cases of adjudication, the HISF Director works with the PIs and coordinators to resolve reporting issues. The HISF promotes the development and incorporation of novel response evaluation methods (imaging biomarkers) for cancer preclinical, translational, and Phase I-III clinical trials. Through scientific collaboration the HISF can facilitate the translation of more sophisticated imaging examinations, image analytics, and metrics utilized by the other imaging cores such as the Preclinical Imaging Shared Facility and Comprehensive Core for Quantitative Imaging Biomarker Analysis and Development. These non-standard advanced image analyses include physiologic MRI (diffusion weighted imaging, dynamic contrast MRI, MR Spectroscopy), investigational PET CT, PET MRI, and Spectral (dual energy) MDCT. Both standard metrics and advanced imaging methods will aid investigators in UAB-CCC programs.

成像组 人体成像共享设施(HISF) 摘要 人类成像共享设施(HISF)加强了UAB中包括的与成像相关的研究活动- CCC的协作小组组合和其他临床试验，通过提供标准化方法 审查每个UAB-CCC方案并协调非常规影像服务。议定书审查是 由两名研究成像协调员执行，他们为常规和非常规研究提供报价 符合机构和国家规定的影像服务。其他HISF服务包括图像 数据传输和特定于协议的成像技术、幻影扫描/现场鉴定成像、物理学家 放射科医生，或放射科技术员的时间，以及为图像数据表单采购信息。图像数据 转账符合所有UAB医疗系统信息安全(HSIS)要求，并定期进行审计 由UAB HSIS提供。准确、及时地分析用于反应评估的常规影像研究 在癌症临床试验中，为UAB-CCC成员提供的服务占了大部分。拥有专门的 在两个放射学研究的协助下协调专科学院放射科医生的解释 成像协调器和度量协调器之间，协议特定的度量由相同的 在每个治疗试验的整个过程中指定读者，以实现一致的纵向指标报告。 在裁决的情况下，HISF主任与私人投资机构和协调员合作，解决报告问题。 HISF促进发展和纳入新的反应评估方法(成像 生物标志物)用于癌症临床前、转化性和I-III期临床试验。通过科学协作 HISF可以促进更复杂的成像检查、图像分析和 其他成像核心使用的指标，如临床前成像共享设施和综合 用于定量成像生物标志物分析和开发的核心。这些非标准的先进形象 分析包括生理性MRI(扩散加权成像、动态增强MRI、磁共振波谱)、 研究性PET CT、PET MRI和Spectral(双能量)MDCT。标准指标和高级指标 成像方法将有助于UAB-CCC项目的调查人员。