Stereoselective Alkene Carbofunctionalization: Method Development and Mechanism
立体选择性烯烃碳官能化:方法开发和机制
基本信息
- 批准号:9896861
- 负责人:
- 金额:$ 46.38万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-04-01 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAlkenesBiologicalCarbonComplexCouplingCyclizationDevelopmentDimerizationEthylenesGoalsGuidelinesHydrogenationLigandsMediatingMetalsMethodsModelingMolecularOrganic SynthesisOutcomes ResearchPathway interactionsPatternPeriodicityPharmacologic SubstanceProductionPublic HealthPyrrolidinesReactionReportingResearchResearch Project GrantsRestRouteSeriesStructureStudy modelsStyrenesVariantbasebiological preparationcatalystchiral moleculedesigndienedrug discoverydrug productionfunctional groupinsightmethod developmentnovelpredictive modelingprograms
项目摘要
Project Summary
The goal of this research program is to develop stereoselective and regioselective alkene
carbofunctionalization methods to enable efficient and sustainable organic syntheses. A major
challenge in pharmaceutical synthesis is the catalytic construction of chiral molecules. Alkenes
are versatile functional groups. 1,2-Dicarbofunctionalization and hydroalkylation of alkenes have
emerged as compelling strategies to rapidly increase molecular complexity, but intermolecular
asymmetric methods have not yet been developed for simple alkenes. The research projects
described in this proposal address these synthetic challenges by developing a series of
enantioselective reductive 1,2-dicarbofunctionalization and branch-selective hydroalkylation
reactions of a broad scope of alkenes. These new methods would enable efficient routes to
access target molecules with complex substitution patterns while introducing stereocenters.
Catalyst development is built on the hypothesis that Ni-mediated radical addition to alkenes could
result in new stereo-determining steps, such as radical capture or reductive elimination.
Systematic mechanistic studies will be carried out to build stereochemical models, and insight
gained will help overcome the limitations encountered in expanding the scope and utility of the
new methods. Preliminary results showing new reactivity and verifying mechanistic proposals
provide compelling evidence for the feasibility of this research. The expected outcomes of this
research are as follows: (1) The development of stereoselective and regioselective reductive
carbofunctionalization reactions of alkenes will allow for efficient access to vicinal disubstitution
patterns and tertiary carbon centers, and thus novel retrosynthetic disconnections of
pharmaceutical molecules; (2) The insight gained from mechanistic studies of model reactions
and catalysts will not only facilitate the rational design of catalysts for the reactions described in
this proposal, but also provide a guideline for understanding Ni-catalyzed coupling reactions more
broadly.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Tianning Diao其他文献
Reaction for coupling 3D molecular fragments expands the chemist’s toolkit
对耦合 3D 分子片段的反应扩展了化学家的工具包
- DOI:
10.1038/d41586-024-03221-8 - 发表时间:
2024-10-09 - 期刊:
- 影响因子:48.500
- 作者:
Jonathan A. Sorbie;Tianning Diao - 通讯作者:
Tianning Diao
Tianning Diao的其他文献
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{{ truncateString('Tianning Diao', 18)}}的其他基金
Stereoselective Alkene Carbofunctionalization: Method Development and Mechanism
立体选择性烯烃碳官能化:方法开发和机制
- 批准号:
10374039 - 财政年份:2019
- 资助金额:
$ 46.38万 - 项目类别:
Stereoselective Alkene Carbofunctionalization: Method Development and Mechanism
立体选择性烯烃碳官能化:方法开发和机制
- 批准号:
10589853 - 财政年份:2019
- 资助金额:
$ 46.38万 - 项目类别:
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