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Characterizing the Spatial Temporal Dynamics and Human Health Risks of Vibrio parahaemolyticus Bacteria in Estuarine Environments

描述河口环境中副溶血性弧菌的时空动态和人类健康风险

基本信息

批准号：
9898224
负责人：
Frank Curriero
金额：
$ 54.59万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-05-02 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9898224
关键词：
Address Aquaculture Area Back Bacteria Bacterial Infections Cessation of life Climate Collaborations Consumption Data Data Set Databases Detection Development Disease Outbreaks Dose Eating Economics Environment Event Exposure to Future Gastroenteritis Goals Harvest Health Health Food Hospitalization Human In Situ International Life Methods Modeling Oceans Output Pathogenicity Policies Prevalence Procedures Public Health Research Risk Risk Assessment Risk Management Seafood Septicemia Shellfish Statistical Methods System Time Uncertainty United States United States Food and Drug Administration Vibrio Vibrio Infections Vibrio parahaemolyticus Washington Water Work base burden of illness data modeling exposure route extreme weather foodborne illness hydrodynamic model improved indexing land use microbial novel pathogen predictive modeling prevent remote sensing response sound spatial temporal variation tool undercooked water quality

项目摘要

Project Summary Non-cholera Vibrio species, such as V. parahaemolyticus, are often an underlying cause of seafood-associated illnesses leading to an estimated 80,000 illnesses, 500 hospitalizations and 100 deaths annually in the United States. Shellfish, which are often consumed raw or undercooked, can accumulate a wide array of infectious pathogen including bacteria, making them a primary exposure route for non-cholera Vibrio infections. As shellfish aquaculture continues to grow in the United States, there is a need for more reliable Vibrio detection methods in harvesting waters in order to better quantify human health risks from these bacteria and to limit the burden of vibriosis. The goals of this research are to characterize levels of Vibrio parahaemolyticus bacteria in estuarine environments and to assess human health risks from this emerging pathogen. Methods developed will be built upon a unique opportunity to work with comprehensive data sets from two large estuarine environments, the Chesapeake Bay and the Puget Sound, which represent two of the most significant economic estuarine systems on the East and West coast of the US. Quantitative analyses will focus on the advancement of spatial and spatial-temporal statistical methods to better quantify uncertainty for spatially predicting in estuarine environments. Statistical results will be used to support the development of a region-specific quantitative microbial risk assessment (QMRA) for vibriosis, extending the Food and Drug Administration's (FDA's) current national risk assessment model. The Puget Sound database includes Vibrio outbreaks traced back to specific harvesting areas, information that will be used to develop a novel dose-response model for the risk assessment. Results of this research will provide reliable tools that can be used to improve risk management procedures for infections from Vibrio parahaemolyticus in both these bodies of water, as well as applications to other estuaries that support shellfish harvesting, leading to increased estuarine economic output, reduced disease burden, and improved public health.

项目摘要非霍乱弧菌种类，如副溶血性弧菌，通常是潜在的与海鲜有关的疾病的原因估计导致80,000种疾病，500 美国每年的住院人数和死亡人数为100人。贝类，这通常是生吃或未煮熟，会积聚多种传染性病原体包括细菌，使其成为非霍乱弧菌的主要接触途径感染。随着贝类水产养殖在美国的持续增长，有必要在采集水中寻找更可靠的弧菌检测方法，以便更好地量化人类减少这些细菌对健康的危害，并限制弧菌病的负担。这项研究的目标是是为了表征河口环境中副溶血性弧菌的水平，以及评估这种新出现的病原体对人类健康的风险。开发的方法将被构建利用来自两个大河口的综合数据集的独特机会环境，切萨皮克湾和普吉特海湾，这是最重要的两个美国东西海岸重要的经济河口系统。量化分析将侧重于空间和时空统计方法的进步，以更好地量化河口环境空间预测的不确定性。统计结果将用于支持制定区域特定的定量微生物风险弧菌病评估(QMRA)，延长食品和药物管理局(FDA)的现行国家风险评估模型。Puget Sound数据库包括追踪到的弧菌爆发回到特定的收获区域，将被用来开发新的剂量反应的信息风险评估的模型。这项研究的结果将提供可靠的工具，用于改进副溶血性弧菌感染的风险管理程序这些水体，以及对其他支持贝类的河口的应用收获，导致河口经济产量增加，减少疾病负担，以及改善公共卫生。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Evaluating the performance of Bayesian geostatistical prediction with physical barriers in the Chesapeake Bay.

评估切萨皮克湾物理屏障的贝叶斯地质统计预测的性能。

DOI：
10.1007/s10661-024-12401-y
发表时间：
2024
期刊：
Environmental monitoring and assessment
影响因子：
3
作者：
Desjardins,MR;Davis,BJK;Curriero,FC
通讯作者：
Curriero,FC

Performance of Cold Chains for Chesapeake Bay Farmed Oysters and Modeled Growth of Vibrio parahaemolyticus.

切萨皮克湾养殖牡蛎的冷链性能和副溶血弧菌的生长模型。

DOI：
10.4315/0362-028x.jfp-18-044
发表时间：
2019
期刊：
Journal of food protection
影响因子：
2
作者：
Love,DavidC;Lane,RobertM;Davis,BenjaminJK;Clancy,Kate;Fry,JillianP;Harding,Jamie;Hudson,Bobbi
通讯作者：
Hudson,Bobbi

Nested Spatial and Temporal Modeling of Environmental Conditions Associated With Genetic Markers of Vibrio parahaemolyticus in Washington State Pacific Oysters.

华盛顿州太平洋牡蛎的嵌套环境条件的嵌套空间和时间建模。

DOI：
10.3389/fmicb.2022.849336
发表时间：
2022
期刊：
FRONTIERS IN MICROBIOLOGY
影响因子：
5.2
作者：
Fries, Brendan;Davis, Benjamin J. K.;Corrigan, Anne E.;DePaola, Angelo;Curriero, Frank C.
通讯作者：
Curriero, Frank C.

A case-control analysis of traceback investigations for Vibrio parahaemolyticus infections (vibriosis) and pre-harvest environmental conditions in Washington State, 2013-2018.