Infrared Methods for Lesion Activity Assessment

病变活动评估的红外方法

• 批准号: 9768429
• 负责人: Nai-Yuan Nicholas Chang
• 金额: $ 5.08万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9768429
• 关键词: Acids; Affect; Chemicals; Chronic Disease; Clinical; Clinical assessments; Color; Coupled; Defect; Dehydration; Dental; Dental Cavity Preparation; Dental Enamel; Dental caries; Dentin; Detection; Development; Diagnosis; Early Diagnosis; Exhibits; Image; Imagery; Imaging technology; Intervention; Lesion; Liquid substance; Location; Measurement; Measures; Methods; Microradiography; Minerals; Monitor; Nonionizing Radiation; Operative Surgical Procedures; Optical Coherence Tomography; Penetration; Permeability; Plant Roots; Polarization Microscopy; Population; Production; Radiation exposure; Research; Resolution; Roentgen Rays; Secondary to; Severities; Stains; Structure; Surface; Technology; Testing; Thick; Time; Tissues; Tooth structure; Water; absorption; accurate diagnosis; base; composite restoration; demineralization; design; detector; digital; handheld equipment; imaging approach; imaging modality; improved; in vivo; innovation; instrument; optical imaging; outreach; portability; remineralization; restoration; sound; success; unnecessary treatment

PROJECT SUMMARY The overall objective of this proposed research is to develop methods for the clinical assessment of lesion structure and activity. Improved imaging technologies employing non-ionizing radiation will significantly improve caries diagnosis and management. It is not sufficient to simply detect carious lesions, methods are needed to assess the activity of the lesion and determine if chemical intervention is needed. The central hypothesis underlying this proposal is that there are structural differences between active lesions due to caries, arrested lesions and developmental defects, and these differences can be quantified using optical imaging methods. There is a transparent highly mineralized outer surface zone presented on arrested lesions formed due to remineralization, which leads to decreased permeability to fluids including water and plaque generated acids. Previous studies have shown that the thickness of this surface zone can be measured nondestructively using polarization sensitive optical coherence tomography (PS-OCT), and have demonstrated that near-IR (NIR) reflectance and thermal imaging coupled with dehydration can be used to measure changes in the permeability of lesions in enamel and dentin. The overall objective of this proposal will be achieved through the following specific aims: (1) To test the hypothesis that the thickness of the highly mineralized transparent surface zone formed during remineralization correlates with the lesion permeability and activity; (2) To test the hypothesis that thermal and NIR reflectance dehydration methods can be used to measure the activity of secondary carious lesions around composite restorations; (3) To test the hypothesis that compact thermal and NIR reflectance probes for lesion activity assessment can be fabricated that are suitable for in vivo use. This project will allow us to determine the structural changes needed to arrest active lesions and provide methods for assessing the activity of lesions in a single examination to avoid unnecessary treatment and cavity preparations.

项目摘要 本研究的总体目标是开发病变的临床评估方法。 结构和活动。采用非电离辐射的改进的成像技术将显著地 改善龋齿诊断和管理。仅仅检测龋损是不够的， 需要评估病变的活性并确定是否需要化学干预。中央 这一建议的基础假设是，由于活动性病变之间存在结构差异， 龋齿，停滞病变和发育缺陷，这些差异可以量化使用 光学成像方法有一个透明的高度矿化的外表面区提出了对逮捕 由于矿化而形成的病变，这导致对包括水和水在内的流体的渗透性降低， 牙菌斑产生酸。以前的研究表明，可以测量这个表面区域的厚度 非破坏性地使用偏振敏感光学相干断层扫描（PS-OCT），并已证明 近红外（NIR）反射率和热成像结合脱水可以用来测量变化 在釉质和牙本质损伤的渗透性。本建议的总体目标将得以实现 通过以下具体目的：（1）验证高度矿化的厚度 透明表面区的形成与病变的通透性和活动性有关; 为了验证热和近红外反射脱水方法可用于测量 复合牙釉质周围继发性龋损的活动性;（3）为了检验复合牙釉质周围继发性龋损的活动性， 可以制造用于损伤活动性评估的热和NIR反射探针 使用.该项目将使我们能够确定阻止活动性病变所需的结构变化， 在一次检查中评估病变活动性的方法，以避免不必要的治疗和空洞 准备工作。