Infrared Methods for Lesion Activity Assessment

项目总结 这项拟议研究的总体目标是开发病变的临床评估方法。 结构和活性。采用非电离辐射的改进的成像技术将显著 提高龋病诊断和管理水平。简单地检测龋齿病变是不够的，方法是 需要评估病变的活动性并确定是否需要化学干预。中环 支持这一建议的假设是，在活动性病变之间存在结构性差异 对龋齿、滞留病变和发育缺陷的影响，这些差异可以用 光学成像方法。有一个透明的高度矿化的外表面区，显示在受阻 由于再矿化而形成的损伤，导致对液体的渗透性降低，包括水和 斑块会产生酸性物质。以前的研究表明，这个表面层的厚度可以测量 非破坏性地使用偏振敏感光学相干层析成像(PS-OCT)，并已证明 近红外(NIR)反射率和结合脱水的热成像可以用来测量变化 病变在牙釉质和牙本质中的渗透性。这项建议的总体目标将会实现 通过以下具体目标：(1)检验高矿化层厚度的假设 再矿化过程中形成的透明表面区与病变的通透性和活动性相关； 为了验证热和近红外反射脱水法可以用来测量 复合修复体周围继发性龋损的活动性；(3)检验致密性假说 用于评估病变活动性的热和近红外反射探头可以被制造成适合于活体的 使用。该项目将使我们能够确定遏制活动性病变所需的结构变化，并提供 一次检查评估病变活动性以避免不必要的治疗和空洞的方法 准备工作。

PROJECT SUMMARY The overall objective of this proposed research is to develop methods for the clinical assessment of lesion structure and activity. Improved imaging technologies employing non-ionizing radiation will significantly improve caries diagnosis and management. It is not sufficient to simply detect carious lesions, methods are needed to assess the activity of the lesion and determine if chemical intervention is needed. The central hypothesis underlying this proposal is that there are structural differences between active lesions due to caries, arrested lesions and developmental defects, and these differences can be quantified using optical imaging methods. There is a transparent highly mineralized outer surface zone presented on arrested lesions formed due to remineralization, which leads to decreased permeability to fluids including water and plaque generated acids. Previous studies have shown that the thickness of this surface zone can be measured nondestructively using polarization sensitive optical coherence tomography (PS-OCT), and have demonstrated that near-IR (NIR) reflectance and thermal imaging coupled with dehydration can be used to measure changes in the permeability of lesions in enamel and dentin. The overall objective of this proposal will be achieved through the following specific aims: (1) To test the hypothesis that the thickness of the highly mineralized transparent surface zone formed during remineralization correlates with the lesion permeability and activity; (2) To test the hypothesis that thermal and NIR reflectance dehydration methods can be used to measure the activity of secondary carious lesions around composite restorations; (3) To test the hypothesis that compact thermal and NIR reflectance probes for lesion activity assessment can be fabricated that are suitable for in vivo use. This project will allow us to determine the structural changes needed to arrest active lesions and provide methods for assessing the activity of lesions in a single examination to avoid unnecessary treatment and cavity preparations.