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Cognitive and Neural Flexibility in Autism

自闭症的认知和神经灵活性

基本信息

批准号：
9769132
负责人：
Lucina Qazi Uddin
金额：
$ 44.53万
依托单位：
UNIVERSITY OF MIAMI CORAL GABLES
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-08 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9769132
关键词：
12 year old Address Affect Age Aman Anterior Attention Behavioral Brain Brain region Caregivers Child Cognition Cognitive Complex Coupling Cues Data Diagnosis Dimensions Disease Early Intervention Etiology Exhibits Functional Magnetic Resonance Imaging Functional disorder Goals Impairment Incidence Individual Insula of Reil Laboratories Life Link Magnetic Resonance Imaging Measures Mental Processes Neurobiology Neurodevelopmental Disorder Pattern Performance Prefrontal Cortex Public Health Publishing Quality of life Readiness Reporting Research Rest Severities Stimulus Strategic Planning Symptoms Task Performances Testing Time Youth attentional control autism spectrum disorder autistic autistic children base behavior measurement behavioral impairment flexibility improved individualized medicine innovation neural circuit neurodevelopment neuroimaging neuromechanism novel novel strategies peer programs public health relevance relating to nervous system repetitive behavior response social communication therapy design

项目摘要

DESCRIPTION (provided by applicant): Autism spectrum disorder (ASD) is a complex neurodevelopment disorder of largely unknown etiology affecting 1 in 68 children. While much progress has been made towards understanding the neurobiology of social and communication deficits associated with the disorder, very little is known regarding the neurobiological basis of restricted and repetitive behaviors central to the ASD diagnosis. The goal of the current project is to understand the relationship between cognitive flexibility and brain function during evoked (task) and intrinsic (resting) states in youth with and without ASD. Cognitive flexibility, the capacity to switch between mental processes, is often impaired in children with ASD in ways that can severely impact transitions during day-to- day activities of life. Cognitive inflexibilitymay underlie the emergence of restricted and repetitive behaviors in ASD. Understanding the neural mechanisms underlying cognitive inflexibility in ASD is critical for tailoring therapies to treat tis under-studied yet pervasive symptom. The PI has recently published preliminary evidence of reduced dynamic range of connectivity patterns, or neural inflexibility, in children with ASD. The proposed research will go beyond these preliminary findings and explicitly test whether one aspect of restricted and repetitive behaviors --cognitive inflexibility-- is linked with a corresponding neural inflexibility in ASD. A novel approach to assessing brain function and dysfunction is the quantification of dynamic functional connectivity, or time-varying patterns of functional coupling between brain regions. The goals of the study are to address three aims: 1) to understand the neural bases of cognitive flexibility in children with ASD and TD children during evoked brain states, 2) to understand the neural bases of cognitive flexibility in children with ASD and TD children during intrinsic brain states, and 3) to investigate relationships between activation patterns during evoked brain states, dynamic functional connectivity patterns during intrinsic brain states, and behavioral measures of flexibility in ASD. To address these aims, the project will implement traditional task- based functional MRI, dynamic functional connectivity analyses of resting-state fMRI, and integration of task and resting state fMRI with behavioral measures of cognitive flexibility. This program of research responds to the Interagency Autism Coordinating Committee's strategic plan to understand the neural circuitry that is affected in ASD. As behavioral inflexibility is an important cause of difficulties in carin for autistic individuals, these findings will potentially have a major impact on quality of life for children with ASD and their caregivers.

项目成果

期刊论文数量（47）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Brain Mechanisms Supporting Flexible Cognition and Behavior in Adolescents With Autism Spectrum Disorder.

DOI：
10.1016/j.biopsych.2020.05.010
发表时间：
2021-01-15
期刊：
Biological psychiatry
影响因子：
10.6
作者：
Uddin LQ
通讯作者：
Uddin LQ

Regression Models for Characterizing Categorical-Dimensional Brain-Behavior Relationships in Clinical Populations.

用于表征临床人群中分类维度脑行为关系的回归模型。

DOI：
10.1016/j.bpsc.2019.03.008
发表时间：
2019
期刊：
Biological psychiatry. Cognitive neuroscience and neuroimaging
影响因子：
0
作者：
Nomi,JasonS
通讯作者：
Nomi,JasonS

Educating the future generation of researchers: A cross-disciplinary survey of trends in analysis methods.

DOI：
10.1371/journal.pbio.3001313
发表时间：
2021-07
期刊：
PLoS biology
影响因子：
9.8
作者：
Bolt T;Nomi JS;Bzdok D;Uddin LQ
通讯作者：
Uddin LQ

Linked Social-Communication Dimensions and Connectivity in Functional Brain Networks in Autism Spectrum Disorder.

DOI：
10.1093/cercor/bhab057
发表时间：
2021-04
期刊：
Cerebral cortex
影响因子：
3.7
作者：
Jinming Xiao;Huafu Chen;Xiaolong Shan;Changchun He;Ya Li;Xiaonan Guo;Heng Chen;W. Liao;L. Uddin;Xujun Duan
通讯作者：
Jinming Xiao;Huafu Chen;Xiaolong Shan;Changchun He;Ya Li;Xiaonan Guo;Heng Chen;W. Liao;L. Uddin;Xujun Duan

Dynamic functional connectivity profile of the salience network across the life span.