Fractal motor activity regulation and the risk for Alzheimers disease in middle-to-old aged adults

分形运动活动调节与中老年人阿尔茨海默病风险

• 批准号: 9579772
• 负责人: Kun Hu
• 金额: $ 272.28万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9579772
• 关键词: Address; Adult; Affect; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; Amygdaloid structure; Biology; Brain; Cardiac; Caregivers; Clinical; Cognition; Cognitive; Complex; Data; Databases; Diagnosis; Disease; Disease Progression; Early identification; Fractals; Genetic Risk; Goals; Health; Heart Rate; Hippocampus (Brain); Homeostasis; Human; Impaired cognition; Individual; Left; Link; Magnetic Resonance Imaging; Measures; Memory Loss; Monitor; Motor Activity; Outcome; Participant; Pathologic; Pathology; Pattern; Phase; Physiological; Physiology; Predictive Value; Process; Regulation; Risk; Screening procedure; Senile Plaques; Structure; Survival Rate; Symptoms; System; Testing; Therapeutic Intervention; Time; Treatment Efficacy; Trees; age effect; aged; base; biobank; cognitive performance; cognitive testing; cost; density; design; entorhinal cortex; follow-up; genetic variant; genome wide association study; healthy aging; improved; pathological aging; pre-clinical; recruit; survival prediction; theories

Project Summary/Abstract Clinical manifestations of Alzheimer's disease (AD) such as memory loss and cognition impairment occur mostly in people aged 65 years. But the disease is believed to progresses silently for more than a decade before its clinical manifestations such that the disease process starts as early as in the middle of 40s. This preclinical phase of AD would provide a critical opportunity for effective therapeutic interventions. Thus, earlier identification of the individuals at the risk for AD is important for better healthy outcomes of these people and their caregivers. The goal of this project is to determine the ability of fractal regulation in physiological fluctuations to predict the risk of AD in middle to old aged people. Many physiological fluctuations including heart rate and motor activity fluctuations display fractal patterns, i.e., the patterns of fluctuations are very similar at different time scales. Numerous studies indicate that fractal regulation imparts considerable physiological advantage in terms of plasticity and adaptability, as exemplified by reduced fractal cardiac and motor activity regulations with aging and under pathological conditions, and most importantly, by the predictive value of reduced fractal cardiac regulation for decreased survival. PI's group is one of the first to show a mechanistic link between degraded fractal regulation and Alzheimer's disease (AD). They found that fractal motor activity regulation (FMAR) is degraded with aging and in AD, and that the degradation is strongly associated with cognitive decline. Based on these preliminary data, the proposal is designed to test whether FMAR alterations predict incident AD in middle to old aged people. To this end, PI and his team propose to study the existing database of UK Biobank (http://www.ukbiobank.ac.uk) in which ~500,000 participants aged between 40-69 years were recruited in 2006-2010 and agreed to have their health followed. The specific aims are 1) to determine the effects of age and genetic risk for AD on FMAR in middle-to-old aged adults; 2) to determine the associations of FMAR with cognition and incident AD in middle-to-old aged adults; and 3) to determine the effects of neuroanatomical changes on FMAR in middle-to-old aged adults. Addressing the aims will provide a first formal assessment of the alterations of fractal regulation from middle to old ages, the underlying neuroanatomical changes, and its ability to predict the risk of AD at early or preclinical stages. These results will lead to a much better understanding of the complex biology and physiology of healthy and pathologic aging in AD, which ought to provide useful guidance for improved diagnosis and treatment of AD or AD-related symptoms.

项目总结/摘要 阿尔茨海默病（AD）的临床表现如记忆力减退和认知功能障碍 大多数是65岁的人。但据信这种疾病会在十多年内悄无声息地发展 在其临床表现之前，疾病过程早在40多岁中期开始。这 AD的临床前阶段将为有效的治疗干预提供关键机会。因此， 识别有AD风险的个体对于这些人更好的健康结果是重要的， 他们的照顾者。本项目的目标是确定分形调节生理的能力， 波动来预测中老年人的AD风险。许多生理波动，包括 心率和运动活动波动显示分形图案，即，波动的模式非常 在不同的时间尺度上是相似的。许多研究表明，分形调控赋予相当大的 在可塑性和适应性方面的生理优势，如减少分形心脏和 运动活动调节与衰老和病理条件下，最重要的是，通过预测 分形心脏调节降低对存活率降低的价值。PI的团队是第一批展示 退化的分形调节和阿尔茨海默病（AD）之间的机械联系。他们发现分形 运动活动调节（FMAR）随着年龄的增长和AD而退化，并且这种退化是强烈的。 与认知能力下降有关根据这些初步数据，该提案旨在测试 FMAR改变预测中老年人AD的发生。为此，PI和他的团队建议， 研究英国生物银行（http：//www.example.com）的现有数据库，其中约有50万名年龄www.ukbiobank.ac.uk 在2006-2010年招募了40-69岁的人，并同意跟踪他们的健康状况。具体目标 1）确定年龄和AD遗传风险对中老年人FMAR的影响; 2） 确定FMAR与中老年人的认知和AD事件之间的关系;以及3） 确定神经解剖学变化对中老年人FMAR的影响。实现目标 将提供第一次正式评估的变化分形规则从中年到老年， 潜在的神经解剖学变化，以及其在早期或临床前阶段预测AD风险的能力。 这些结果将使我们更好地了解健康和免疫系统的复杂生物学和生理学， AD的病理老化，这应该为改善AD的诊断和治疗提供有用的指导， AD相关症状

项目成果

COVID-19-Related News Consumption Linked with Stress and Worry, but Not Sleep Quality, Early in the Pandemic

• DOI: 10.1080/13548506.2022.2141281
• 发表时间: 2022-11-03
• 期刊: PSYCHOLOGY HEALTH & MEDICINE
• 影响因子: 3.8
• 作者: Ladis, Ilana;Gao, Chenlu;Scullin, Michael K.
• 通讯作者: Scullin, Michael K.

Daily rhythm of dynamic cerebral autoregulation in patients after stroke.

脑卒中后患者动态脑自动调节的每日节律。

• DOI: 10.1177/0271678x231153750
• 发表时间: 2023
• 期刊: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
• 作者: Abadjiev,DanielS;Toschi-Dias,Edgar;Salinet,AngelaSm;Gaykova,NicoleN;Lo,Men-Tzung;Nogueira,RicardoC;Hu,Kun
• 通讯作者: Hu,Kun

Chronotype in college science students is associated with behavioral choices and can fluctuate across a semester

• DOI: 10.1080/07420528.2023.2203251
• 发表时间: 2023-04-22
• 期刊: CHRONOBIOLOGY INTERNATIONAL
• 影响因子: 2.8
• 作者: Barley, Blake K.;Gao, Chenlu;Scullin, Michael K.
• 通讯作者: Scullin, Michael K.