A novel approach to improve patient care and diarrheal disease research using mobile technology

利用移动技术改善患者护理和腹泻病研究的新方法

基本信息

  • 批准号:
    9561920
  • 负责人:
  • 金额:
    $ 35.78万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-10-13 至 2020-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Diarrheal disease is the second leading cause of death among children under 5 years of age globally. We are specifically interested in the diarrheal disease cholera because of the devastating impact the disease has on at-risk populations and an emerging opportunity to leverage mobile technology to overcome fundamental clinical and scientific challenges we have faced for decades in the cholera field. Despite effective treatments and advances in provider education, cholera case fatality rates remain high. Conventional methods have been unable to overcome barriers to provide patients timely access to care and fully understand the disease at the level of the household. With the emergence of high rates of cell phone penetration in areas with significant cholera associated morbidity and mortality, we feel there are new opportunities for intervention. Our research challenge is to take an unconventional approach to develop a system using mobile technology to identify cases, improve access to care, and characterize the microbial flora early in the disease state. The application's specific aims are (i) develop a system to detect cholera patients early in disease using mobile technology, (ii) validate the detection system and clinical impact of the system in an interrupted time series study with a control group, and (iii) characterize the microbial flora of cholera stool during the early disease state. These aims will generate the following deliverables: We will show for the first time that mobile technology can be used to identify and provide ORS to diarrheal disease patients early in disease. We will show that mobile technology can be leveraged to decrease the incidence and severity of cases admitted to the hospital. Lastly, we will implement the system to characterize cholera stool using modern techniques early in disease for the first time, which may impact our fundamental understanding of correlates to disease progression and transmission.
描述(由申请人提供):腹泻病是全球5岁以下儿童死亡的第二大原因。我们对霍乱特别感兴趣,因为该疾病对高危人群造成了毁灭性影响,并出现了利用移动的技术克服我们在霍乱领域数十年来面临的基本临床和科学挑战的新机会。尽管提供了有效的治疗和先进的提供者教育,霍乱病例死亡率仍然很高。传统方法无法克服障碍,使病人及时获得护理,并在家庭一级充分了解这一疾病。随着手机普及率在霍乱相关发病率和死亡率高的地区的出现,我们认为有新的干预机会。我们的研究挑战是采取非传统的方法来开发一个系统,使用移动的技术来识别病例,改善获得护理的机会,并在疾病状态的早期表征微生物植物群。该应用程序的具体目标是(i)开发一个系统,使用移动的技术在疾病早期检测霍乱患者,(ii)验证检测系统和 该系统在中断的时间序列研究与对照组,和(iii)表征的微生物植物群的霍乱粪便在早期疾病状态。这些目标将产生以下可交付成果:我们将首次展示移动的技术可用于在疾病早期识别并向糖尿病患者提供ORS。我们将展示移动的技术可以用来降低入院病例的发生率和严重程度。最后,我们将实施该系统,首次在疾病早期使用现代技术来表征霍乱粪便,这可能会影响我们对疾病进展和传播相关性的基本理解。

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(1)
An ethnographic exploration of diarrheal disease management in public hospitals in Bangladesh: From problems to solutions.
  • DOI:
    10.1016/j.socscimed.2020.113185
  • 发表时间:
    2020-09
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Biswas D;Hossin R;Rahman M;Bardosh KL;Watt MH;Zion MI;Sujon H;Rashid MM;Salimuzzaman M;Flora MS;Qadri F;Khan AI;Nelson EJ
  • 通讯作者:
    Nelson EJ
Genome-wide association studies reveal distinct genetic correlates and increased heritability of antimicrobial resistance in Vibrio cholerae under anaerobic conditions.
  • DOI:
    10.1099/mgen.0.000905
  • 发表时间:
    2022-12
  • 期刊:
  • 影响因子:
    3.9
  • 作者:
    Creasy-Marrazzo, Ashton;Saber, Morteza M;Kamat, Manasi;Bailey, Laura S;Brinkley, Lindsey;Cato, Emilee;Begum, Yasmin;Rashid, Md Mahbubur;Khan, Ashraful I;Qadri, Firdausi;Basso, Kari B;Shapiro, B Jesse;Nelson, Eric J
  • 通讯作者:
    Nelson, Eric J
High-throughput low-cost nl-qPCR for enteropathogen detection: A proof-of-concept among hospitalized patients in Bangladesh.
  • DOI:
    10.1371/journal.pone.0257708
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    3.7
  • 作者:
    Flaherty KE;Grembi JA;Ramachandran VV;Haque F;Khatun S;Rahman M;Maples S;Becker TK;Spormann AM;Schoolnik GK;Hryckowian AJ;Nelson EJ
  • 通讯作者:
    Nelson EJ
Opportunities to catalyse improved healthcare access in pluralistic systems: a cross-sectional study in Haiti.
  • DOI:
    10.1136/bmjopen-2020-047367
  • 发表时间:
    2021-11-22
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Klarman M;Schon J;Cajusma Y;Maples S;Beau de Rochars VEM;Baril C;Nelson EJ
  • 通讯作者:
    Nelson EJ
Development and evaluation of a clinical guideline for a paediatric telemedicine service in a low-resource setting.
在低资源环境中针对儿科远程医疗服务的临床指南的开发和评估。
  • DOI:
    10.1136/bmjpo-2023-002164
  • 发表时间:
    2024-01-08
  • 期刊:
  • 影响因子:
    2.6
  • 作者:
  • 通讯作者:
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Eric Jorge Nelson其他文献

Eric Jorge Nelson的其他文献

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{{ truncateString('Eric Jorge Nelson', 18)}}的其他基金

Improving Performance of a Pediatric TeleMedicine and Medication Delivery Service through mHealth Technology
通过移动医疗技术提高儿科远程医疗和药物输送服务的性能
  • 批准号:
    10741179
  • 财政年份:
    2023
  • 资助金额:
    $ 35.78万
  • 项目类别:
A novel approach to improve patient care and diarrheal disease research using mobile technology
利用移动技术改善患者护理和腹泻病研究的新方法
  • 批准号:
    9349388
  • 财政年份:
    2016
  • 资助金额:
    $ 35.78万
  • 项目类别:
A novel approach to improve patient care and diarrheal disease research using mobile technology
利用移动技术改善患者护理和腹泻病研究的新方法
  • 批准号:
    8927095
  • 财政年份:
    2014
  • 资助金额:
    $ 35.78万
  • 项目类别:

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