2020 Angiotensin GRC/GRS

2020 血管紧张素 GRC/GRS

• 批准号: 9898612
• 负责人: MARIA LUISA Soledad SEQUEIRA-LOPEZ
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9898612
• 关键词: Academia; Address; Adult; Angiotensins; Anniversary; Area; Arizona; Award; Basic Science; Benefits and Risks; Bioinformatics; Blood Vessels; Brain; Cardiovascular Diseases; Cardiovascular Physiology; Cells; Child; Circadian Rhythms; Clinical; Clinical Investigator; Clinical Research; Collaborations; Denmark; Development; Discipline; Disease; Educational workshop; Electrolytes; Embryo; Engineering; Environment; Exposure to; Face; Family; Fostering; Funding; Future; Gender; Genomics; Government; Growth; Health; Homeostasis; Hour; Hypertension; Image; Immune system; Industry; Innate Immune Response; Institutes; International; Kidney Diseases; Lead; Leadership; Liquid substance; Mentors; Mission; Modeling; National Heart, Lung, and Blood Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Natural regeneration; Nervous system structure; Neuroimmunomodulation; Oral; Pathologic Processes; Patients; Peripheral Nervous System; Postdoctoral Fellow; Process; Public Health; Recording of previous events; Regulation; Renal Hypertension; Renal function; Renin-Angiotensin-Aldosterone System; Research; Research Personnel; Running; Schedule; Science; Scientific Advances and Accomplishments; Scientist; Senior Scientist; Series; Signal Pathway; Societies; Solid; Source; Time; Training; Travel; Underrepresented Groups; Underrepresented Minority; United States National Institutes of Health; Universities; Virginia; Woman; blood pressure regulation; burden of illness; career; career development; clinical application; drug discovery; drug testing; epigenomics; genome-wide; graduate student; improved; innovation; interest; meetings; new technology; novel; novel therapeutics; operation; personalized medicine; personalized therapeutic; posters; preservation; programs; role model; symposium; transcriptomics; translational approach; translational scientist; undergraduate student; underrepresented minority student

PROJECT SUMMARY The Renin Angiotensin Aldosterone System (RAAS) is crucial for the regulation of blood pressure and fluid electrolyte homeostasis. In addition, the RAAS is involved in vascular development, regeneration, innate immune responses and the operation of the central and peripheral nervous systems. When the RAAS is deranged, it is often at the center of numerous pathological processes leading to cardiovascular and renal diseases and hypertension. On its 40th anniversary, the 2020 Angiotensin Gordon Research Conference (GRC) will focus on integrating novel technologies, clinical studies and personalized therapeutics to preserve health. Recent intellectual and technological advances on single cell transcriptomics, epigenomics, locus- specific (epi)genomic engineering, genome-wide modelling, imaging, and sophisticated drug discovery and testing are leading to groundbreaking fundamental discoveries which pave the way for personalized medicine. Thus, the GRC will highlight innovations on the RAAS that expand from solid basic research to clinical applications and public health impact. Novel discoveries on neuro-immune mechanisms, higher brain functions, regeneration, circadian rhythms, and the risks and benefits of novel therapeutic strategies targeting the RAAS will also be discussed. The Gordon Research Seminar (GRS) will discuss the RAAS in diseases beyond hypertension, novel signaling pathways, and bioinformatics, and include trainee presentations and mentoring series. The GRS, organized by trainees with support of lead scientists from the associated GRC, is held in conjunction with (during the weekend immediately prior to) the GRC. The GRC/GRS’ aims are to discuss original unpublished research and technical advances on RAAS by a diverse group of basic, clinical and translational investigators at all career levels, foster new collaborations, advance the scientific career of junior investigators-trainees and develop, diversify and sustain a strong scientific workforce. The aims are aligned with the NHLBI and NIDDK missions and the scientific themes that will be covered are of direct relevance to both institutes. The GRC/GRS provide an excellent training and networking environment. To stimulate discussions and explore applications of discoveries from other scientific fields to the RAAS area, we invited internationally recognized experts who have not previously attended the Angiotensin GRC. To nurture interactions between trainees and senior scientists we scheduled: 1) 4 Poster Sessions 2) A Power Hour: open forum to support the professional growth of women by discussing challenges that women face in science 3) A Career Development Session and 4) A Mentee-Mentor Pairing Program. NIH funds requested for this conference will help attract trainees, women and scientists from underrepresented groups which currently have limited opportunities to attend one of the best conferences in their field. Novel advances on the RAAS have the potential to improve substantially the management of adults and children with cardiovascular and renal diseases and reduce the burden of disease in patients, their families and our society.

项目摘要 肾素-血管紧张素-醛固酮系统（RAAS）是调节血压和体液的关键 电解质稳态此外，RAAS参与血管发育、再生、先天性 免疫反应以及中枢和外周神经系统的运作。当RAAS 精神错乱，它往往是许多病理过程的中心，导致心血管和肾脏疾病， 疾病和高血压。在其成立40周年之际，2020年血管紧张素戈登研究会议 (GRC)将专注于整合新技术，临床研究和个性化治疗，以保护 健康在单细胞转录组学、表观基因组学、基因座组学、基因组学和基因组学等方面的最新知识和技术进展。 特异性（epi）基因组工程，全基因组建模，成像和复杂的药物发现， 测试正在导致突破性的基本发现，为个性化医疗铺平道路。 因此，GRC将突出RAAS的创新，从坚实的基础研究扩展到临床 应用和公共卫生影响。神经免疫机制的新发现，高级脑 功能，再生，昼夜节律，以及针对新的治疗策略的风险和益处 我们亦会讨论RAAS。戈登研究研讨会（GRS）将讨论疾病中的RAAS 超越高血压，新的信号通路和生物信息学，并包括学员介绍， 指导系列。GRS由受训人员在相关GRC的首席科学家的支持下组织， 与GRC一起举行（在紧接之前的周末）。GRC/GRS的目标是 讨论原始未发表的研究和技术进展RAAS由不同的基础，临床， 和翻译研究人员在所有职业水平，促进新的合作，推进科学事业， 培训初级科研人员-受训人员，并发展、多样化和维持一支强大的科研队伍。其宗旨是 与NHLBI和NIDDK任务保持一致，将涵盖的科学主题是直接的 这对两个机构都有意义。GRC/GRS提供了良好的培训和网络环境。到 鼓励讨论和探索从其他科学领域的发现应用到RAAS领域，我们 邀请国际公认的专家谁没有参加过血管紧张素GRC。培养 我们安排了学员和高级科学家之间的互动：1）4个海报会议2）一个电源小时：开放 通过讨论妇女在科学领域面临的挑战，支持妇女职业发展的论坛 职业发展会议和4）导师配对计划。NIH为此申请的资金 会议将有助于吸引学员，妇女和科学家从代表性不足的群体，目前有 有限的机会参加他们领域最好的会议之一。RAAS的新进展 有可能大幅改善患有心血管和肾脏疾病的成人和儿童的管理 减少疾病对患者、家庭和社会的负担。