2020 Angiotensin GRC/GRS

项目总结 肾素-血管紧张素-醛固酮系统(RAAS)对血压和液体的调节至关重要。 电解质动态平衡。此外，RAAS还参与血管的发育、再生、先天 免疫反应和中枢和外周神经系统的运作。当RAAS是 它精神错乱，经常处于导致心血管和肾脏的众多病理过程的中心 疾病和高血压。在成立40周年之际，2020年血管紧张素-戈登研究会议 (GRC)将专注于整合新技术、临床研究和个性化治疗，以保存 健康。在单细胞转录组学、表观基因组学、基因座研究方面的最新智力和技术进展 特定(EPI)基因组工程、全基因组建模、成像和复杂的药物发现和 测试正在导致突破性的基础性发现，为个性化医学铺平道路。 因此，GRC将突出RAAS的创新，这些创新从坚实的基础研究扩展到临床 应用程序和公共卫生影响。神经免疫机制的新发现，高等大脑 功能、再生、昼夜节律以及新的靶向治疗策略的风险和好处 还将讨论RAAS。戈登研究研讨会(GRS)将讨论RAAS在疾病中的作用 除高血压外，新的信号通路和生物信息学，并包括实习生演示和 辅导系列。GRS由受训人员组织，并得到相关GRC的首席科学家的支持，是 与GRC同时举行(在紧接其前的周末举行)。GRC/GRS的目标是 讨论RAAS的原始未发表研究和技术进展，由不同的基础、临床小组进行 和各个职业层次的翻译研究人员，促进新的合作，推进 初级调查人员--受训人员，并发展、多样化和维持一支强大的科学队伍。我们的目标是 与NHLBI和NIDDK任务相一致，将涵盖的科学主题是直接 与这两个研究所都有关联。GRC/GRS提供了良好的培训和网络环境。至 激发讨论并探索将其他科学领域的发现应用于RAAS领域，我们 邀请了以前没有参加过血管紧张素GRC的国际公认的专家。培养 学员和资深科学家之间的互动我们计划：1)4个海报会议2)动力一小时：开放 通过讨论妇女在科学领域面临的挑战来支持妇女职业成长的论坛3)A 职业发展会议和4)辅导者-导师配对计划。美国国立卫生研究院为此申请资金 会议将有助于吸引来自代表性不足群体的受训者、女性和科学家，这些群体目前有 参加他们所在领域最好的会议之一的机会有限。RAAS的新进展有 大幅改善成人和儿童心血管和肾脏疾病管理的潜力 减少患者、他们的家人和我们社会的疾病负担。

PROJECT SUMMARY The Renin Angiotensin Aldosterone System (RAAS) is crucial for the regulation of blood pressure and fluid electrolyte homeostasis. In addition, the RAAS is involved in vascular development, regeneration, innate immune responses and the operation of the central and peripheral nervous systems. When the RAAS is deranged, it is often at the center of numerous pathological processes leading to cardiovascular and renal diseases and hypertension. On its 40th anniversary, the 2020 Angiotensin Gordon Research Conference (GRC) will focus on integrating novel technologies, clinical studies and personalized therapeutics to preserve health. Recent intellectual and technological advances on single cell transcriptomics, epigenomics, locus- specific (epi)genomic engineering, genome-wide modelling, imaging, and sophisticated drug discovery and testing are leading to groundbreaking fundamental discoveries which pave the way for personalized medicine. Thus, the GRC will highlight innovations on the RAAS that expand from solid basic research to clinical applications and public health impact. Novel discoveries on neuro-immune mechanisms, higher brain functions, regeneration, circadian rhythms, and the risks and benefits of novel therapeutic strategies targeting the RAAS will also be discussed. The Gordon Research Seminar (GRS) will discuss the RAAS in diseases beyond hypertension, novel signaling pathways, and bioinformatics, and include trainee presentations and mentoring series. The GRS, organized by trainees with support of lead scientists from the associated GRC, is held in conjunction with (during the weekend immediately prior to) the GRC. The GRC/GRS’ aims are to discuss original unpublished research and technical advances on RAAS by a diverse group of basic, clinical and translational investigators at all career levels, foster new collaborations, advance the scientific career of junior investigators-trainees and develop, diversify and sustain a strong scientific workforce. The aims are aligned with the NHLBI and NIDDK missions and the scientific themes that will be covered are of direct relevance to both institutes. The GRC/GRS provide an excellent training and networking environment. To stimulate discussions and explore applications of discoveries from other scientific fields to the RAAS area, we invited internationally recognized experts who have not previously attended the Angiotensin GRC. To nurture interactions between trainees and senior scientists we scheduled: 1) 4 Poster Sessions 2) A Power Hour: open forum to support the professional growth of women by discussing challenges that women face in science 3) A Career Development Session and 4) A Mentee-Mentor Pairing Program. NIH funds requested for this conference will help attract trainees, women and scientists from underrepresented groups which currently have limited opportunities to attend one of the best conferences in their field. Novel advances on the RAAS have the potential to improve substantially the management of adults and children with cardiovascular and renal diseases and reduce the burden of disease in patients, their families and our society.